Engineering living systems on chips: from cells to human on chips

Optimizing the structure and contractility of engineered skeletal muscle thin films

(2013) Y. Sun et al.   Acta Biomaterialia

Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems

(2013) J. P. Wikswo et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Nanostructured self-assembling peptides as a defined extracellular matrix for long-term functional maintenance of primary hepatocytes in a bioartificial liver modular device

(2013) Shibashish Giri et al.   International Journal of Nanomedicine

Microfabricated mammalian organ systems and their integration into models of whole animals and humans

(2013) Jong H. Sung et al.   LAB ON A CHIP

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro

(2013) D.-H. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microfluidic System for Facilitated Quantification of Nanoparticle Accumulation to Cells Under Laminar Flow

(2012) Jiro Kusunose et al.   ANNALS OF BIOMEDICAL ENGINEERING

Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture

(2012) Adam W. Feinberg et al.   BIOMATERIALS

On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic ‘body-on-a-chip’ devices

(2012) Mandy Brigitte Esch et al.   BIOMEDICAL MICRODEVICES

Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism

(2012) J. M. Munson et al.   CANCER RESEARCH

A novel three-dimensional bone chip organ culture

(2012) Johannes Kuttenberger et al.   Clinical Oral Investigations

In vitro formation and characterization of a perfusable three-dimensional tubular capillary network in microfluidic devices

(2012) Ju Hun Yeon et al.   LAB ON A CHIP

Formation and optogenetic control of engineered 3D skeletal muscle bioactuators

(2012) Mahmut Selman Sakar et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

A microfluidic flow-stretch chip for investigating blood vessel biomechanics

(2012) Wenfu Zheng et al.   LAB ON A CHIP

DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays

(2012) Vyomesh Patel et al.   ORAL ONCOLOGY

Muscle on a chip: In vitro contractility assays for smooth and striated muscle

(2012) Anna Grosberg et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

A Microfluidic System for Testing the Responses of Head and Neck Squamous Cell Carcinoma Tissue Biopsies to Treatment with Chemotherapy Drugs

(2011) Samantha M. Hattersley et al.   ANNALS OF BIOMEDICAL ENGINEERING

Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

(2011) Christopher Moraes et al.   ANNALS OF BIOMEDICAL ENGINEERING

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

Study of ethanol induced toxicity in liver explants using microfluidic devices

(2011) Samantha M. Hattersley et al.   BIOMEDICAL MICRODEVICES

Tumor Cell Invasion Is Promoted by Interstitial Flow-Induced Matrix Priming by Stromal Fibroblasts

(2011) A. C. Shieh et al.   CANCER RESEARCH

Biomimetic tissues on a chip for drug discovery

(2011) Amir M. Ghaemmaghami et al.   DRUG DISCOVERY TODAY

In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients

(2011) Yoojin Shin et al.   LAB ON A CHIP

Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip

(2011) Anna Grosberg et al.   LAB ON A CHIP

Imitation of drug metabolism in human liver and cytotoxicity assay using a microfluidic device coupled to mass spectrometric detection

(2011) Sifeng Mao et al.   LAB ON A CHIP

Interview: Trevor Keel from the World Gold Council

(2011) Trevor Keel   Nanomedicine

Detection of Dynamic Spatiotemporal Response to Periodic Chemical Stimulation in a Xenopus Embryonic Tissue

(2011) YongTae Kim et al.   PLoS One

Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve

(2011) K. Balachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Predictive toxicology using systemic biology and liver microfluidic “on chip” approaches: Application to acetaminophen injury

(2011) Jean-Matthieu Prot et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Engineering the Lymphatic System

(2011) Matthew E. Nipper et al.   Cardiovascular Engineering and Technology

Shape Effect of Carbon Nanovectors on Angiogenesis

(2010) Padmaparna Chaudhuri et al.   ACS Nano

Electrically induced contraction of C2C12 myotubes cultured on a porous membrane-based substrate with muscle tissue-like stiffness

(2010) Hirokazu Kaji et al.   BIOMATERIALS

Lectin-aided separation of circulating tumor cells and assay of their response to an anticancer drug in an integrated microfluidic device

(2010) Li Li et al.   ELECTROPHORESIS

Microfluidic cell arrays for metabolic monitoring of stimulated cardiomyocytes

(2010) Wei Cheng et al.   ELECTROPHORESIS

A microfluidic platform for probing small artery structure and function

(2010) Axel Günther et al.   LAB ON A CHIP

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

A tissue-engineered model of the intestinal lacteal for evaluating lipid transport by lymphatics

(2009) J. Brandon Dixon et al.   BIOTECHNOLOGY AND BIOENGINEERING

Amyotrophic Lateral Sclerosis-Like Conditions in Possible Association with Cholesterol-Lowering Drugs

(2009) Beatrice A. Golomb et al.   DRUG SAFETY

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Co-culture of epithelial cells and bacteria for investigating host–pathogen interactions

(2009) Jeongyun Kim et al.   LAB ON A CHIP

Paracrine induction of endothelium by tumor exosomes

(2009) Joshua L Hood et al.   LABORATORY INVESTIGATION

Probing Cellular Dynamics with a Chemical Signal Generator

(2009) Brandon Kuczenski et al.   PLoS One

How Humans Differ from Other Animals in Their Levels of Morphological Variation

(2009) Ann E. McKellar et al.   PLoS One

Defining the role of syndecan-4 in mechanotransduction using surface-modification approaches

(2009) Robert M. Bellin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Culture Models in Microfluidic Systems

(2008) Ivar Meyvantsson et al.   Annual Review of Analytical Chemistry

Engineered neuronal circuits shaped and interfaced with carbon nanotube microelectrode arrays

(2008) M. Shein et al.   BIOMEDICAL MICRODEVICES

Cell migration into scaffolds under co-culture conditions in a microfluidic platform

(2008) Seok Chung et al.   LAB ON A CHIP

Electrical Stimulation of Neural Stem Cells Mediated by Humanized Carbon Nanotube Composite Made with Extracellular Matrix Protein

(2008) Nadine Wong Shi Kam et al.   NANO LETTERS