Inverting Small Molecule-Protein Recognition by the Fluorine Gauche Effect: Selectivity Regulated by Multiple H→F Bioisosterism

Efficient and Practical Deacylation Reaction System in a Continuous Packed-Bed Reactor

(2019) Hiroaki Yasukouchi et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Informing Molecular Design by Stereoelectronic Theory: The Fluorine Gauche Effect in Catalysis

(2018) Marialuisa Aufiero et al.   ACCOUNTS OF CHEMICAL RESEARCH

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

(2018) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Enantioselective, Catalytic Vicinal Difluorination of Alkenes

(2018) Felix Scheidt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exploring physicochemical space via a bioisostere of the trifluoromethyl and ethyl groups (BITE): attenuating lipophilicity in fluorinated analogues of Gilenya® for multiple sclerosis

(2018) Nathalie Erdeljac et al.   CHEMICAL COMMUNICATIONS

Synthesis and Biological Evaluation of Bromo- and Fluorodanicalipin A

(2016) Stefan Fischer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Emulating Natural Product Conformation by Cooperative, Non-Covalent Fluorine Interactions

(2016) Felix Scheidt et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Fluorine Gauche Effect: A Brief History

(2016) Christian Thiehoff et al.   ISRAEL JOURNAL OF CHEMISTRY

Catalytic Difluorination of Olefins

(2016) István Gábor Molnár et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic, Diastereoselective 1,2-Difluorination of Alkenes

(2016) Steven M. Banik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective aldol reactions with masked fluoroacetates

(2016) Jakub Saadi et al.   Nature Chemistry

Catalytic, Vicinal Difluorination of Olefins: Creating a Hybrid, Chiral Bioisostere of the Trifluoromethyl and Ethyl Groups

(2016) István G. Molnár et al.   ACS Catalysis

Organofluorine chemistry: applications, sources and sustainability

(2015) Antal Harsanyi et al.   GREEN CHEMISTRY

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery

(2015) Quentin A. Huchet et al.   JOURNAL OF MEDICINAL CHEMISTRY

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Recognition of Fluorine Impacts Substrate Selectivity in the Fluoroacetyl-CoA Thioesterase FlK

(2014) Amy M. Weeks et al.   BIOCHEMISTRY

Organofluorine Chemistry: Synthesis and Conformation of Vicinal Fluoromethylene Motifs

(2012) David O’Hagan   JOURNAL OF ORGANIC CHEMISTRY

Catalytic control of enzymatic fluorine specificity

(2012) A. M. Weeks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Escape from Flatland 2: complexity and promiscuity

(2012) Frank Lovering   MedChemComm

Fluorine Conformational Effects in Organocatalysis: An Emerging Strategy for Molecular Design

(2011) Lucie E. Zimmer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorinated amino acids: compatibility with native protein structures and effects on protein–protein interactions

(2011) Mario Salwiczek et al.   CHEMICAL SOCIETY REVIEWS

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Diastereoselective Synthesis of 2,3,4,5,6-Pentafluoroheptanes

(2009) Daniel Farran et al.   JOURNAL OF ORGANIC CHEMISTRY

Use of fluorinated functionality in enzyme inhibitor development: Mechanistic and analytical advantages

(2008) David B. Berkowitz et al.   JOURNAL OF FLUORINE CHEMISTRY

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS