Article
Cell Biology
Yuting Tang, Qinghai Zhu, Li Yang, Ying Meng, Gao Zhang, Tian Zhou, Chenxing Wang, Xiaomeng Song, Yu-Xiong Su, Jinhai Ye
Summary: This study demonstrates that miR-200b-5p can suppress the proliferation, migration, invasion, and EMT of SACC by regulating BTBD1 and the PI3K/AKT pathway, providing a promising therapeutic target for SACC treatment.
CELLULAR SIGNALLING
(2023)
Article
Pathology
Chen-xing Hou, Li Wang, Man Cai, Ying Meng, Yu-ting Tang, Qing-hai Zhu, Wei Han, Nan-nan Sun, Ben Ma, Yong Hu, Jin-hai Ye
Summary: Sphk1 is overexpressed in salivary adenoid cystic carcinoma (SACC), promoting tumorigenesis by activating the PI3K/Akt pathway. This finding provides novel intervention targets for SACC treatment.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Review
Biochemistry & Molecular Biology
Suguru Kadomoto, Kouji Izumi, Atsushi Mizokami
Summary: Chemokines are a family of cytokines that play important roles in cancer progression. The CCL2-CCR2 axis is a major chemokine signaling pathway that impacts tumor progression significantly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Liyang Fei, Xiaochen Ren, Haijia Yu, Yifan Zhan
Summary: CCR2 is predominantly expressed by monocytes/macrophages with proinflammatory functions, and targeting CCR2 has been investigated as a strategy to modify the tumor microenvironment and enhance anti-tumor immunity. In addition to blocking chemotaxis of suppressive myeloid cells, CCR2 signaling has underappreciated effects on myeloid cell survival and function polarization. T cells also express CCR2, and targeting CCR2 is shown to favor the anti-tumor arm of immune responses by affecting tissue homing of Treg cells and enhancing Treg functional potency.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Xiao Yang, Jia-shun Wu, Mao Li, Wei-long Zhang, Xiao-lei Gao, Hao-fan Wang, Xiang-hua Yu, Xin Pang, Mei Zhang, Xin-hua Liang, Ya-ling Tang
Summary: The study investigated the role of the DEC2 gene in tumor dormancy and metastasis in salivary adenoid cystic carcinoma (SACC). The results showed that DEC2 overexpression inhibited cell proliferation, while reduced DEC2 levels led to dormancy exit and growth resumption of SACC cells. Additionally, DEC2 was found to be associated with hypoxia in contributing to tumor dormancy, providing a possible explanation for its different roles in primary and metastasis lesions.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Chemistry, Multidisciplinary
Caiyan Zhao, Xiaoyu Pang, Zuo Yang, Sheng Wang, Hongzhang Deng, Xiaoyuan Chen
Summary: TAMs are key players in tumor progression and can be modulated using nanotechnology-based strategies, such as inhibiting their recruitment, depleting M2-polarized macrophages, and reprogramming them into M1-polarized macrophages. Nanoparticles can also be used to image TAMs for novel treatment options and therapy monitoring.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Mao Li, Zi-xin Wan, Yue-yang Tang, Xin-hua Liang, Ya-ling Tang
Summary: Immunohistochemical staining was used to detect the expression of TIM-3, Gal-9, and CD160 in SACC and their correlation with clinicopathological characteristics. The results showed that overexpression of TIM-3 and CD160 were associated with SACC recurrence, while high expression of Gal-9 was correlated with pathological classification. The average percentage of TILs in SACC was 18.2%, with a higher occurrence in minor salivary glands. There were positive correlations observed between the expression of TIM-3, Gal-9, and CD160 in tumor cells and TILs. These findings suggest that the density of TILs and the expression of TIM-3, Gal-9, and CD160 could be potential therapeutic targets in SACC.
Review
Immunology
Kim Ngan Luu Hoang, Joanne E. Anstee, James N. Arnold
Summary: HO-1 is an inducible intracellular enzyme expressed in various cancers to promote tumor progression through intracellular and extracellular mechanisms. Its catabolites provide antioxidant, anti-apoptotic, and cytoprotective effects within cells, while also influencing the wider tumor microenvironment to promote processes like angiogenesis, metastasis, anti-inflammation, and immune suppression. Pharmacological inhibition of HO-1 shows promise in inhibiting metastasis and promoting anti-tumor immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Sosuke Sahara, Alexandra E. Herzog, Jacques E. Nor
Summary: Adenoid cystic carcinoma (ACC) is a rare cancer with no standard chemotherapy currently available. Response rates to cytotoxic agents are around 10%, while combination therapies like CAP and cisplatin-vinorelbine have response rates of 18-31%. Inhibitors targeting VEGFR show relatively high response rates of 11-17%. Targeting cancer stem cells (CSC), drivers of chemoresistance and recurrence, could lead to valuable therapies for ACC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Taito Miyamoto, Ryusuke Murakami, Junzo Hamanishi, Kenji Tanigaki, Yuko Hosoe, Nathan Mise, Shiro Takamatsu, Yuka Mise, Masayo Ukita, Mana Taki, Koji Yamanoi, Naoki Horikawa, Kaoru Abiko, Ken Yamaguchi, Tsukasa Baba, Noriomi Matsumura, Masaki Mandai
Summary: This study explored the immunosuppressive effect of B7-H3 in high-grade serous ovarian cancer (HGSOC) and found that it contributes to immune suppression and tumor progression through the CCL2-CCR2-M2 macrophage axis. These findings provide new insights into the immunologic tumor microenvironment and could aid the development of new therapeutic approaches.
CANCER IMMUNOLOGY RESEARCH
(2022)
Review
Oncology
Xinqun Huang, Jingsong Cao, Xuyu Zu
Summary: In breast cancer, tumor-associated macrophages (TAMs) play a crucial role in promoting tumor growth through various mechanisms, but can promote tumor regression by repolarizing into M1 macrophages. TAMs are established as effective targets for breast cancer treatment.
Review
Cell Biology
Maosen Xu, Yang Wang, Ruolan Xia, Yuquan Wei, Xiawei Wei
Summary: The chemokine ligand CCL2 and its receptor CCR2 play crucial roles in the initiation and progression of cancer by promoting tumor cell growth, migration, and recruitment of immunosuppressive cells. Studies have shown that therapeutic strategies targeting the CCL2-CCR2 axis are promising in combating cancer.
CELL PROLIFERATION
(2021)
Review
Oncology
Xingxing Zhang, Wenxiu Bai, Lisha Hu, Hualan Ha, Yuelin Du, Wei Xiong, Hongbo Wang, Panfeng Shang
Summary: Macrophages, the most abundant immune cells in tumor tissues, mainly exhibit a tumor-promoting phenotype and play a key role in tumor progression and metastasis. However, the clinical trial results of macrophage-targeted therapy have not been as effective as expected, possibly due to the limited understanding of macrophages in the complex human microenvironment. Recent progress in single-cell RNA sequencing has provided a new understanding of the origin, classification, and functional mechanism of tumor-associated macrophages.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aydar Khabipov, Dung Nguyen Trung, Julia van der Linde, Lea Miebach, Maik Lenz, Felix Erne, Wolfram von Bernstorff, Tobias Schulze, Stephan Kersting, Sander Bekeschus, Lars Ivo Partecke
Summary: Pancreatic cancer is characterized by a tumor microenvironment rich in stromal and immune cells that support cancer growth and resistance to therapy. Tumor-associated macrophages (TAMs), specifically, have properties that promote angiogenesis and metastasis, leading to the failure of conventional therapies. This study explores the effects of blocking the C-C chemokine receptor type 4 (CCR4) in pancreatic cancer-bearing mice through genetic or immunotherapeutic methods. The results show that CCR4 is critical for TAM generation and tumor progression in pancreatic cancer, and blockade of CCR4 may improve prognosis and extend the relapse-free period after curative surgery.
Article
Biotechnology & Applied Microbiology
Xiaoxiao Zheng, Jiabin Chen, Tianhao Nan, Li Zheng, Jiahua Lan, Xiaoqin Jin, Ying Cai, Hao Liu, Wei Chen
Summary: This study reveals the expression and function of FAM198B in tumor-associated macrophages (TAMs) and its role in mediating macrophage polarization in colorectal cancer (CRC). FAM198B promotes M2 macrophage polarization, leading to CRC cell proliferation, migration, and invasion. Mechanistically, FAM198B regulates macrophage polarization by targeting SMAD2, indicating its involvement in promoting CRC progression.