Anti-Inflammatory Effects by Pharmacological Inhibition or Knockdown of Fatty Acid Amide Hydrolase in BV2 Microglial Cells

Effect of endocannabinoid signalling on cell fate: life, death, differentiation and proliferation of brain cells

(2018) Moises Garcia-Arencibia et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of interleukin 1-beta in the inflammatory response in a fatty acid amide hydrolase-knockout mouse model of Alzheimer’s disease

(2018) Noelia Aparicio et al.   BIOCHEMICAL PHARMACOLOGY

Therapeutic effect of a novel fatty acid amide hydrolase inhibitor PF04457845 in the repetitive closed head injury mouse model

(2018) Prabhuanand Selvaraj et al.   JOURNAL OF NEUROTRAUMA

Endocannabinoids: Effectors of glucocorticoid signaling

(2017) Georgia Balsevich et al.   FRONTIERS IN NEUROENDOCRINOLOGY

An Introduction to the Endogenous Cannabinoid System

(2016) Hui-Chen Lu et al.   BIOLOGICAL PSYCHIATRY

Cannabinoid receptor-2 stimulation suppresses neuroinflammation by regulating microglial M1/M2 polarization through the cAMP/PKA pathway in an experimental GMH rat model

(2016) Yihao Tao et al.   BRAIN BEHAVIOR AND IMMUNITY

Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson’s disease

(2016) Marta Celorrio et al.   BRAIN BEHAVIOR AND IMMUNITY

The Role of the Endocannabinoid System in the Brain–Gut Axis

(2016) Keith A. Sharkey et al.   GASTROENTEROLOGY

Microglia activation states and cannabinoid system: Therapeutic implications

(2016) M. Mecha et al.   PHARMACOLOGY & THERAPEUTICS

EndogenousN-acyl taurines regulate skin wound healing

(2016) Oscar Sasso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of murine microglial N9 cells is attenuated through cannabinoid receptor CB2 signaling

(2015) Lei Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endocannabinoids drive the acquisition of an alternative phenotype in microglia

(2015) M. Mecha et al.   BRAIN BEHAVIOR AND IMMUNITY

The L-type voltage-gated calcium channel modulates microglial pro-inflammatory activity

(2015) J.F. Espinosa-Parrilla et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Alternatively activated microglia and macrophages in the central nervous system

(2015) Rafael Franco et al.   PROGRESS IN NEUROBIOLOGY

Anandamide, Acting viaCB2Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures

(2015) Natalia Malek et al.   NEURAL PLASTICITY

Effects of the endogenous cannabinoid anandamide on voltage-dependent sodium and calcium channels in rat ventricular myocytes

(2014) Lina T Al Kury et al.   BRITISH JOURNAL OF PHARMACOLOGY

Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies

(2014) Mauro Maccarrone et al.   NATURE REVIEWS NEUROSCIENCE

The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury

(2014) Flaubert Tchantchou et al.   NEUROPHARMACOLOGY

Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells

(2013) H Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

β−Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB1 or CB2 receptors

(2012) Cristina Benito et al.   BRITISH JOURNAL OF PHARMACOLOGY

The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB1- and FAAH-independent mechanisms

(2012) Barbara Bosier et al.   BRITISH JOURNAL OF PHARMACOLOGY

CD200-CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation

(2012) Miriam Hernangómez et al.   GLIA

Involvement of ERK1/2, cPLA2 and NF-κB in microglia suppression by cannabinoid receptor agonists and antagonists

(2012) Rachel Ribeiro et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

(2011) K. Ahn et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Energy balance regulation by endocannabinoids at central and peripheral levels

(2011) Carmelo Quarta et al.   TRENDS IN MOLECULAR MEDICINE

N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor

(2010) Douglas McHugh et al.   BMC NEUROSCIENCE

Regulation of nausea and vomiting by cannabinoids

(2010) Linda A Parker et al.   BRITISH JOURNAL OF PHARMACOLOGY

An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase

(2010) Jonathan Z. Long et al.   JOURNAL OF LIPID RESEARCH

Molecular Basis for a High-Potency Open-Channel Block of Kv1.5 Channel by the Endocannabinoid Anandamide

(2010) E. G. Moreno-Galindo et al.   MOLECULAR PHARMACOLOGY

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)

(2009) Douglas S. Johnson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

(2009) Kay Ahn et al.   CHEMISTRY & BIOLOGY

Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders

(2009) Kay Ahn et al.   Expert Opinion on Drug Discovery

Opposite effects of anandamide andn-arachidonoyl dopamine in the regulation of prostaglandin E2and 8-iso-PGF2αformation in primary glial cells

(2009) Carmen M. Navarrete et al.   JOURNAL OF NEUROCHEMISTRY

Systemic lipopolysaccharide (LPS)-induced microglial activation results in different temporal reduction of CD200 and CD200 receptor gene expression in the brain

(2009) Willias Masocha   JOURNAL OF NEUROIMMUNOLOGY

Endocannabinoid-Mediated Control of Synaptic Transmission

(2009) Masanobu Kano et al.   PHYSIOLOGICAL REVIEWS

Inhibition of fatty acid amide hydrolase produces PPAR-α-mediated analgesia in a rat model of inflammatory pain

(2008) D R Sagar et al.   BRITISH JOURNAL OF PHARMACOLOGY

The endocannabinoid anandamide inhibits potassium conductance in rat cortical astrocytes

(2008) M. Vignali et al.   GLIA

GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current

(2008) J. E. Lauckner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors

(2007) S E O'Sullivan   BRITISH JOURNAL OF PHARMACOLOGY