Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

(2009) Kay Ahn et al.   CHEMISTRY & BIOLOGY

Synergy between Enzyme Inhibitors of Fatty Acid Amide Hydrolase and Cyclooxygenase in Visceral Nociception

(2009) P. S. Naidu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Endocannabinoid Modulation of Scratching Response in an Acute Allergenic Model: A New Prospective Neural Therapeutic Target for Pruritus

(2009) J. E. Schlosburg et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Biochemical and Biological Properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a Mechanism-Based Inhibitor of Fatty Acid Amide Hydrolase

(2008) Mark J. Karbarz et al.   ANESTHESIA AND ANALGESIA

Fatty Acid Amide Hydrolase Inhibition Heightens Anandamide Signaling Without Producing Reinforcing Effects in Primates

(2008) Zuzana Justinova et al.   BIOLOGICAL PSYCHIATRY

Genetic Loss of Faah Compromises Male Fertility in Mice1

(2008) Xiaofei Sun et al.   BIOLOGY OF REPRODUCTION

Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH)

(2008) Amy Timmons et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase

(2008) John M. Keith et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling

(2008) Heather S. Hoover et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enzymatic Pathways That Regulate Endocannabinoid Signaling in the Nervous System

(2008) Kay Ahn et al.   CHEMICAL REVIEWS

Biosynthesis, degradation and pharmacological importance of the fatty acid amides

(2008) Emma K. Farrell et al.   DRUG DISCOVERY TODAY

Activation of cannabinoid CB1 receptors in the dorsolateral periaqueductal gray induces anxiolytic effects in rats submitted to the Vogel conflict test

(2008) Sabrina F. Lisboa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cannabinoid and opioid modulation of social play behavior in adolescent rats: Differential behavioral mechanisms

(2008) Viviana Trezza et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The cannabinoid CB1receptor and the endocannabinoid anandamide: possible antidepressant targets

(2008) Francis Rodriguez Bambico et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Discovery of Boronic Acids as Novel and Potent Inhibitors of Fatty Acid Amide Hydrolase

(2008) Anna Minkkilä et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optimization of the Central Heterocycle of α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase

(2008) Joie Garfunkle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optimization of α-Ketooxazole Inhibitors of Fatty Acid Amide Hydrolase

(2008) F. Scott Kimball et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Quantitative Structure−Activity Relationship of Fatty Acid Amide Hydrolase Inhibitors: Modulation at the N-Portion of Biphenyl-3-yl Alkylcarbamates

(2008) Marco Mor et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Development of Fatty Acid Amide Hydrolase (FAAH) Inhibitors

(2008) Mark Seierstad et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Evaluation of Benzothiazole-Based Analogues as Novel, Potent, and Selective Fatty Acid Amide Hydrolase Inhibitors

(2008) Xueqing Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors

(2008) Martin A. Storr et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Endogenous Fatty Acid Ethanolamides Suppress Nicotine-Induced Activation of Mesolimbic Dopamine Neurons through Nuclear Receptors

(2008) M. Melis et al.   JOURNAL OF NEUROSCIENCE

Inhibition of Anandamide Hydrolysis by Cyclohexyl Carbamic Acid 3'-Carbamoyl-3-yl Ester (URB597) Reverses Abuse-Related Behavioral and Neurochemical Effects of Nicotine in Rats

(2008) M. Scherma et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology

Targeting the endocannabinoid system: to enhance or reduce?

(2008) Vincenzo Di Marzo   NATURE REVIEWS DRUG DISCOVERY

The role of the endocannabinoid system in the pathophysiology and treatment of irritable bowel syndrome

(2008) m. a. storr et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse

(2008) J.A. Palmer et al.   NEUROSCIENCE

Structure-guided inhibitor design for human FAAH by interspecies active site conversion

(2008) M. Mileni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An endocannabinoid signaling system modulates anxiety-like behavior in male Syrian hamsters

(2008) Anna M. Moise et al.   PSYCHOPHARMACOLOGY

Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling

(2007) Alessio Lodola et al.   CHEMICAL COMMUNICATIONS

Evaluation of fatty acid amides in the carrageenan-induced paw edema model

(2007) Laura E. Wise et al.   NEUROPHARMACOLOGY

The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition

(2007) Maria Scherma et al.   NEUROPHARMACOLOGY

Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors

(2007) Fabricio A. Moreira et al.   NEUROPHARMACOLOGY

Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

(2006) Leon Chang et al.   BRITISH JOURNAL OF PHARMACOLOGY