Strategies to Interfere with Tumor Metabolism through the Interplay of Innate and Adaptive Immunity

Tumour-associated macrophages-derived CXCL8 determines immune evasion through autonomous PD-L1 expression in gastric cancer

(2019) Chao Lin et al.   GUT

Iron as a Central Player and Promising Target in Cancer Progression

(2019) Michaela Jung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functional Proteomics of Breast Cancer Metabolism Identifies GLUL as Responder during Hypoxic Adaptation

(2019) Stephan Bernhardt et al.   JOURNAL OF PROTEOME RESEARCH

Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia

(2019) Yuanyuan Wang et al.   Nature Communications

Chronic Hypoxia Enhances β-Oxidation-Dependent Electron Transport via Electron Transferring Flavoproteins

(2019) Dominik C. Fuhrmann et al.   Cells

Tumour-associated macrophages are associated with poor prognosis and programmed death ligand 1 expression in oesophageal cancer

(2019) Taisuke Yagi et al.   EUROPEAN JOURNAL OF CANCER

Targeting Tumor-Associated Macrophages in Cancer

(2019) Paulina Pathria et al.   TRENDS IN IMMUNOLOGY

Degradation of the mitochondrial complex I assembly factor TMEM126B under chronic hypoxia

(2018) Dominik C. Fuhrmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The metabolic axis of macrophage and immune cell polarization

(2018) Spencer A. Hobson-Gutierrez et al.   Disease Models & Mechanisms

Alterations in Cellular Iron Metabolism Provide More Therapeutic Opportunities for Cancer

(2018) Liangfu Zhou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MiR-3662 suppresses hepatocellular carcinoma growth through inhibition of HIF-1α-mediated Warburg effect

(2018) Zhiqiang Chen et al.   Cell Death & Disease

Metabolic consequences of HIF silencing in a triple negative human breast cancer xenograft

(2018) Santosh K. Bharti et al.   Oncotarget

Stromal Infiltration of Tumor-Associated Macrophages Conferring Poor Prognosis of Patients with Basal-Like Breast Carcinoma

(2018) Mu Yang et al.   Journal of Cancer

Targeting Myeloid-Derived Suppressor Cells to Bypass Tumor-Induced Immunosuppression

(2018) Viktor Fleming et al.   Frontiers in Immunology

Metabolic Stress in the Immune Function of T Cells, Macrophages and Dendritic Cells

(2018) Charlotte Domblides et al.   Cells

Double genetic disruption of lactate dehydrogenase A and B is required to ablate the ‘Warburg effect’ restricting tumor growth to oxidative metabolism

(2018) Maša Ždralević et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Checkpoints: Novel Avenues for Immunotherapy of Cancer

(2018) Ivan Shevchenko et al.   Frontiers in Immunology

Integrated multi-omics characterization reveals a distinctive metabolic signature and the role of NDUFA4L2 in promoting angiogenesis, chemoresistance, and mitochondrial dysfunction in clear cell renal cell carcinoma

(2018) Giuseppe Lucarelli et al.   Aging-US

Iron Depletion Affects Genes Encoding Mitochondrial Electron Transport Chain and Genes of Non­Oxidative Metabolism, Pyruvate Kinase and Lactate Dehydrogenase, in Primary Human Cardiac Myocytes Cultured upon Mechanical Stretch

(2018) Magdalena Dziegala et al.   Cells

Iron in the Tumor Microenvironment—Connecting the Dots

(2018) Christa Pfeifhofer-Obermair et al.   Frontiers in Oncology

Metabolism and TAM functions-it takes two to tango

(2017) Massimiliano Mazzone et al.   FEBS Journal

Dietary iron loading negatively affects liver mitochondrial function

(2017) Chiara Volani et al.   Metallomics

Metabolic origins of spatial organization in the tumor microenvironment

(2017) Carlos Carmona-Fontaine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GLUT1 regulates cell glycolysis and proliferation in prostate cancer

(2017) Hengjun Xiao et al.   PROSTATE

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

(2017) Lidia Bosurgi et al.   SCIENCE

Disrupting glucose-6-phosphate isomerase fully suppresses the “Warburg effect” and activates OXPHOS with minimal impact on tumor growth except in hypoxia

(2017) Monique Cunha de Padua et al.   Oncotarget

Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy

(2017) Xiang Zheng et al.   Oncotarget

The emerging role and targetability of the TCA cycle in cancer metabolism

(2017) Nicole M. Anderson et al.   Protein & Cell

The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels

(2017) Anna L Miles et al.   eLife

Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages

(2017) Milene Costa da Silva et al.   Frontiers in Immunology

Reprogramming of Tumor-Associated Macrophages with Anticancer Therapies: Radiotherapy versus Chemo- and Immunotherapies

(2017) Géraldine Genard et al.   Frontiers in Immunology

Monitoring and Targeting Anti-VEGF Induced Hypoxia within the Viable Tumor by 19 F–MRI and Multispectral Analysis

(2017) Yunzhou Shi et al.   NEOPLASIA

Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment

(2017) Christina Mertens et al.   OncoImmunology

Mitochondrial complex I deactivation is related to superoxide production in acute hypoxia

(2017) Pablo Hernansanz-Agustín et al.   Redox Biology

Mitochondrial composition and function under the control of hypoxia

(2017) Dominik C. Fuhrmann et al.   Redox Biology

Tumor-associated macrophages: Potential therapeutic targets for anti-cancer therapy

(2016) Yoshihiro Komohara et al.   ADVANCED DRUG DELIVERY REVIEWS

The Warburg effect: 80 years on

(2016) Michelle Potter et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Targeting Iron in Colon Cancer via Glycoconjugation of Thiosemicarbazone Prochelators

(2016) Eman A. Akam et al.   BIOCONJUGATE CHEMISTRY

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche

(2016) David Clever et al.   CELL

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

(2016) Willy Hugo et al.   CELL

Immune suppressive mechanisms in the tumor microenvironment

(2016) David H Munn et al.   CURRENT OPINION IN IMMUNOLOGY

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

(2016) Nicole E. Scharping et al.   IMMUNITY

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

(2016) Stanley Ching-Cheng Huang et al.   IMMUNITY

Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment

(2016) Jaehong Kim et al.   MEDIATORS OF INFLAMMATION

Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs

(2016) Ryan J. Cummings et al.   NATURE

Lipocalin 2 from macrophages stimulated by tumor cell–derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis

(2016) Michaela Jung et al.   Science Signaling

Hypoxia-induced CCL28 promotes recruitment of regulatory T cells and tumor growth in liver cancer

(2016) Li Ren et al.   Oncotarget

Lipocalin 2 from macrophages stimulated by tumor cell–derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis

(2016) Michaela Jung et al.   Science Signaling

Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia

(2016) Nicole E. Scharping et al.   Cancer Immunology Research

Starved and Asphyxiated: How Can CD8+ T Cells within a Tumor Microenvironment Prevent Tumor Progression

(2016) Ying Zhang et al.   Frontiers in Immunology

Hypoxia inducible factor-1α: Its role in colorectal carcinogenesis and metastasis

(2015) Ganji Purnachandra Nagaraju et al.   CANCER LETTERS

Tumor microenvironment: Sanctuary of the devil

(2015) Lanlan Hui et al.   CANCER LETTERS

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

Macrophage iron homeostasis and polarization in the context of cancer

(2015) Michaela Jung et al.   IMMUNOBIOLOGY

Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected

(2015) Douglas Marvel et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages

(2015) Stefano Ugel et al.   JOURNAL OF CLINICAL INVESTIGATION

CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages

(2015) Takanori Kitamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The interaction of anticancer therapies with tumor-associated macrophages

(2015) Alberto Mantovani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immunological mechanisms of the antitumor effects of supplemental oxygenation

(2015) Stephen M. Hatfield et al.   Science Translational Medicine

MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer

(2015) Catherine Olesch et al.   Oncotarget

Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen

(2015) Isabel Siegert et al.   Cell Reports

TNF Counterbalances the Emergence of M2 Tumor Macrophages

(2015) Franz Kratochvill et al.   Cell Reports

Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies

(2015) F. Hossain et al.   Cancer Immunology Research

Phenotype, development, and biological function of myeloid-derived suppressor cells

(2015) Yang Zhao et al.   OncoImmunology

Macrophage Polarization In The Tumor Microenvironment

(2015) Bernhard Brüne et al.   Redox Biology

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intracellular reduction/activation of a disulfide switch in thiosemicarbazone iron chelators

(2014) Eman A. Akam et al.   Metallomics

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: an open-label, multicenter phase 1b study

(2014) Irene Brana et al.   Targeted Oncology

Chronic hypoxia alters mitochondrial composition in human macrophages

(2013) Dominik Christian Fuhrmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Disulfide/thiol switches in thiosemicarbazone ligands for redox-directed iron chelation

(2013) Tsuhen M. Chang et al.   DALTON TRANSACTIONS

Myeloid-Derived Suppressor Cells Suppress Antitumor Immune Responses through IDO Expression and Correlate with Lymph Node Metastasis in Patients with Breast Cancer

(2013) J. Yu et al.   JOURNAL OF IMMUNOLOGY

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Myeloid derived suppressor cells – a new therapeutic target in the treatment of cancer

(2013) Robert Wesolowski et al.   Journal for ImmunoTherapy of Cancer

S1P Regulation of Macrophage Functions in the Context of Cancer

(2012) Andreas Weigert et al.   Anti-Cancer Agents in Medicinal Chemistry

Hepcidin and iron homeostasis

(2012) Tomas Ganz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hypoxia-Inducible Factor-2  Activation Promotes Colorectal Cancer Progression by Dysregulating Iron Homeostasis

(2012) X. Xue et al.   CANCER RESEARCH

Ketone body utilization drives tumor growth and metastasis

(2012) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer

(2012) Kenneth J. Pienta et al.   INVESTIGATIONAL NEW DRUGS

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells

(2012) David K. Finlay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells

(2012) Christophe J. De Saedeleer et al.   PLoS One

Induction of hypoxia inducible factor (HIF-1α) in rat kidneys by iron chelation with the hydroxypyridinone, CP94

(2011) Jin Hyen Baek et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Metabolic Connections during Apoptotic Cell Engulfment

(2011) Claudia Z. Han et al.   CELL

Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity

(2011) Daniel Tello et al.   Cell Metabolism

Differential gene expression in normal and transformed human mammary epithelial cells in response to oxidative stress

(2011) Diego F. Cortes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

(2011) Andrea Facciabene et al.   NATURE

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

(2011) David G. DeNardo et al.   Cancer Discovery

The Hepcidin-Ferroportin System as a Therapeutic Target in Anemias and Iron Overload Disorders

(2011) T. Ganz et al.   Hematology-American Society of Hematology Education Program

Role of the hypoxia inducible factors HIF in iron metabolism

(2010) Carole Peyssonnaux et al.   CELL CYCLE

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

The multikinase inhibitor Sorafenib reverses the suppression of IL-12 and enhancement of IL-10 by PGE2 in murine macrophages

(2010) Justin P. Edwards et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

(2010) Sara Gardenghi et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissues

(2010) Christopher D Gregory et al.   JOURNAL OF PATHOLOGY

Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases

(2009) Rasheduzzaman Chowdhury et al.   STRUCTURE

Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network

(2008) Martina U. Muckenthaler et al.   Annual Review of Nutrition

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

Receptor-mediated uptake of ferritin-bound iron by human intestinal Caco-2 cells

(2008) Swati Kalgaonkar et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Donation Frequency, Iron Loss, and Risk of Cancer Among Blood Donors

(2008) Gustaf Edgren et al.   JNCI-Journal of the National Cancer Institute