The Hepcidin-Ferroportin System as a Therapeutic Target in Anemias and Iron Overload Disorders

Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice

(2011) K. E. Finberg et al.   BLOOD

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

(2011) A. U. Steinbicker et al.   BLOOD

Pharmacokinetics, pharmacodynamics and safety of a human anti-IL-6 monoclonal antibody (sirukumab) in healthy subjects in a first-in-human study

(2011) Zhenhua Xu et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

(2011) Emilio Ramos et al.   HEPATOLOGY

Hepcidin and Disorders of Iron Metabolism

(2010) Tomas Ganz et al.   Annual Review of Medicine

Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia

(2010) B. J. Sasu et al.   BLOOD

Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo

(2010) M. Poli et al.   BLOOD

Detection, evaluation, and management of iron-restricted erythropoiesis

(2010) L. T. Goodnough et al.   BLOOD

Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease

(2010) S.-N. J. Song et al.   BLOOD

BMP6 Treatment Compensates for the Molecular Defect and Ameliorates Hemochromatosis in Hfe Knockout Mice

(2010) Elena Corradini et al.   GASTROENTEROLOGY

Anemia, Ineffective Erythropoiesis, and Hepcidin: Interacting Factors in Abnormal Iron Metabolism Leading to Iron Overload in β-Thalassemia

(2010) Sara Gardenghi et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

(2010) Sara Gardenghi et al.   JOURNAL OF CLINICAL INVESTIGATION

Natural and synthetic STAT3 inhibitors reduce hepcidin expression in differentiated mouse hepatocytes expressing the active phosphorylated STAT3 form

(2010) Nadia Fatih et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The molecular basis of hepcidin-resistant hereditary hemochromatosis

(2009) A. Fernandes et al.   BLOOD

Hepcidin--A Potential Novel Biomarker for Iron Status in Chronic Kidney Disease

(2009) J. Zaritsky et al.   Clinical Journal of the American Society of Nephrology

Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin

(2009) D. R. Ashby et al.   HAEMATOLOGICA

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Tocilizumab, a humanized anti-interleukin-6 receptor antibody, improved anemia in monkey arthritis by suppressing IL-6-induced hepcidin production

(2009) Misato Hashizume et al.   RHEUMATOLOGY INTERNATIONAL

Immunoassay for human serum hepcidin

(2008) T. Ganz et al.   BLOOD

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

(2008) Laura Silvestri et al.   Cell Metabolism

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

(2008) Karin E Finberg et al.   NATURE GENETICS