Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion

Quercetin inhibits cell viability, migration and invasion by regulating miR-16/HOXA10 axis in oral cancer

(2019) Junfang Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors

(2019) Mohamed Mahameed et al.   Cell Death & Disease

The role of XBP1s in the metastasis and prognosis of hepatocellular carcinoma

(2018) Sudong Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Decreased cytoplasmic X-box binding protein-1 expression is associated with poor prognosis and overall survival in patients with oral squamous cell carcinoma

(2018) Hui-Ting Hsu et al.   CLINICA CHIMICA ACTA

Dual IRE1 RNase functions dictate glioblastoma development

(2018) Stéphanie Lhomond et al.   EMBO Molecular Medicine

Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications

(2018) Aitor Almanza et al.   FEBS Journal

Adaptive adhesion systems mediate glioma cell invasion in complex environments

(2018) Pavlo G. Gritsenko et al.   JOURNAL OF CELL SCIENCE

Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α

(2018) Denisse Sepulveda et al.   MOLECULAR CELL

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

XBP1 promotes tumor invasion and is associated with poor prognosis in oral squamous cell carcinoma

(2018) Yanan Sun et al.   ONCOLOGY REPORTS

Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases

(2018) Arnaud Pommier et al.   SCIENCE

ER stress sensing mechanism: Putting off the brake on UPR transducers

(2018) Diego Rojas-Rivera et al.   Oncotarget

Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer

(2018) Reo Fukushima et al.   Journal of Cancer

The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance

(2018) Emma Madden et al.   BIOLOGY OF THE CELL

Tumour heterogeneity and metastasis at single-cell resolution

(2018) Devon A. Lawson et al.   NATURE CELL BIOLOGY

Regulation of tumor-stroma interactions by the unfolded protein response

(2017) Joanna Obacz et al.   FEBS Journal

Rho GTPase signaling complexes in cell migration and invasion

(2017) Campbell D. Lawson et al.   JOURNAL OF CELL BIOLOGY

Knockdown of IRE1α inhibits colonic tumorigenesis through decreasing β-catenin and IRE1α targeting suppresses colon cancer cells

(2017) X-X Li et al.   ONCOGENE

Endoplasmic reticulum proteostasis in glioblastoma—From molecular mechanisms to therapeutic perspectives

(2017) Joanna Obacz et al.   Science Signaling

Acriflavine Inhibits Acquired Drug Resistance by Blocking the Epithelial-to-Mesenchymal Transition and the Unfolded Protein Response

(2017) Jeroen Dekervel et al.   Translational Oncology

Tumor Cell Invadopodia: Invasive Protrusions that Orchestrate Metastasis

(2017) Robert J. Eddy et al.   TRENDS IN CELL BIOLOGY

High expression of glucose-regulated protein 78 (GRP78) is associated with metastasis and poor prognosis in patients with esophageal squamous cell carcinoma

(2017) Peng Ren et al.   OncoTargets and Therapy

Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1

(2017) Yu-Xiong Feng et al.   Nature Communications

Common cytotoxic chemotherapeutics induce epithelial-mesenchymal transition (EMT) downstream of ER stress

(2017) Parag P. Shah et al.   Oncotarget

An unfolded protein-induced conformational switch activates mammalian IRE1

(2017) G Elif Karagöz et al.   eLife

Endoplasmic reticulum proteostasis in glioblastoma—From molecular mechanisms to therapeutic perspectives

(2017) Joanna Obacz et al.   Science Signaling

Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers

(2017) T Avril et al.   Oncogenesis

Apigenin inhibits TNFα/IL-1α-induced CCL2 release through IKBK-epsilon signaling in MDA-MB-231 human breast cancer cells

(2017) David Bauer et al.   PLoS One

Gemcitabine treatment induces endoplasmic reticular (ER) stress and subsequently upregulates urokinase plasminogen activator (uPA) to block mitochondrial-dependent apoptosis in Panc-1 cancer stem-like cells (CSCs)

(2017) Li Wang et al.   PLoS One

LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway

(2017) Eva P. Cuevas et al.   Scientific Reports

The unfolded protein response impacts melanoma progression by enhancing FGF expression and can be antagonized by a chemical chaperone

(2017) Karin Eigner et al.   Scientific Reports

Activation of IRE1α-XBP1 pathway induces cell proliferation and invasion in colorectal carcinoma

(2016) Chun Jin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A collective route to metastasis: Seeding by tumor cell clusters

(2016) K. J. Cheung et al.   SCIENCE

Increased phosphorylation of eIF2α in chronic myeloid leukemia cells stimulates secretion of matrix modifying enzymes

(2016) Paulina Podszywalow-Bartnicka et al.   Oncotarget

Apigenin inhibits NF-κB and Snail signaling, EMT and metastasis in human hepatocellular carcinoma

(2016) Yuan Qin et al.   Oncotarget

Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma

(2016) Hui-Hui Cao et al.   Scientific Reports

Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression

(2016) Michael M. Lizardo et al.   NEOPLASIA

Kaempferol Inhibits Pancreatic Cancer Cell Growth and Migration through the Blockade of EGFR-Related Pathway In Vitro

(2016) Jungwhoi Lee et al.   PLoS One

Baicalin and baicalein inhibit transforming growth factor-β1-mediated epithelial-mesenchymal transition in human breast epithelial cells

(2015) Heesung Chung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway

(2015) Chia-Hung Lin et al.   BMC CANCER

Suppressed invasive and migratory behaviors of SW1353 chondrosarcoma cells through the regulation of Src, Rac1 GTPase, and MMP13

(2015) Wenxiao Xu et al.   CELLULAR SIGNALLING

XBP1 induces snail expression to promote epithelial- to-mesenchymal transition and invasion of breast cancer cells

(2015) Haiyu Li et al.   CELLULAR SIGNALLING

Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression

(2015) Balbino L. Santos et al.   CHEMICO-BIOLOGICAL INTERACTIONS

TGF-β-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination

(2015) Gaia Cantelli et al.   CURRENT BIOLOGY

Rho GTPase signalling in cell migration

(2015) Anne J Ridley   CURRENT OPINION IN CELL BIOLOGY

Inositol-requiring protein 1 – X-box-binding protein 1 pathway promotes epithelial–mesenchymal transition via mediating snail expression in pulmonary fibrosis

(2015) Xiao-Ting Mo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

X-box binding protein 1 (XBP-1) enhances colorectal cancer cell invasion

(2015) Nizar M. Mhaidat et al.   JOURNAL OF CHEMOTHERAPY

Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1 expression

(2015) Thaiz Ferraz Borin et al.   JOURNAL OF PINEAL RESEARCH

Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia

(2015) Cheng-Shi Xu et al.   Journal of Translational Medicine

Hypoxia-inducible factor 1 and breast cancer metastasis

(2015) Zhao-ji Liu et al.   Journal of Zhejiang University-SCIENCE B

Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion

(2015) Hui-Hui Cao et al.   Molecular Cancer

Src family kinases differentially influence glioma growth and motility

(2015) Laura J. Lewis-Tuffin et al.   Molecular Oncology

Proteostasis control by the unfolded protein response

(2015) Claudio Hetz et al.   NATURE CELL BIOLOGY

Novel roles of the unfolded protein response in the control of tumor development and aggressiveness

(2015) Nicolas Dejeans et al.   SEMINARS IN CANCER BIOLOGY

Collective cell migration: guidance principles and hierarchies

(2015) Anna Haeger et al.   TRENDS IN CELL BIOLOGY

Endoplasmic Reticulum Stress-Activated Cell Reprogramming in Oncogenesis

(2015) E. Chevet et al.   Cancer Discovery

Filamin A phosphorylation by Akt promotes cell migration in response to arsenic

(2015) Lingzhi Li et al.   Oncotarget

Glioblastoma invasion and cooption depend on IRE1α endoribonuclease activity

(2015) Arnaud Jabouille et al.   Oncotarget

Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling

(2015) Marta Carrara et al.   eLife

Kaempferol Suppresses Transforming Growth Factor-β1–Induced Epithelial-to-Mesenchymal Transition and Migration of A549 Lung Cancer Cells by Inhibiting Akt1-Mediated Phosphorylation of Smad3 at Threonine-179

(2015) Eunji Jo et al.   NEOPLASIA

OASIS/CREB3L1is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migrationin vitro

(2015) Michael Rose et al.   Epigenetics

Pancreatic Endoplasmic Reticulum Kinase Activation Promotes Medulloblastoma Cell Migration and Invasion through Induction of Vascular Endothelial Growth Factor A

(2015) Stephanie Jamison et al.   PLoS One

Hypoxic regulation of the PERK/ATF4/LAMP3-arm of the unfolded protein response in head and neck squamous cell carcinoma

(2014) Anika Nagelkerke et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

CCR7: Roles in cancer cell dissemination, migration and metastasis formation

(2014) Daniel F. Legler et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Attenuation of malignant phenotypes of breast cancer cells through eIF2α-mediated downregulation of Rac1 signaling

(2014) KAZUNORI HAMAMURA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Activating Transcription Factor 3-mediated Chemo-intervention with Cancer Chemokines in a Noncanonical Pathway under Endoplasmic Reticulum Stress

(2014) Seong-Hwan Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum Stress-Activated Transcription Factor ATF6  Requires the Disulfide Isomerase PDIA5 To Modulate Chemoresistance

(2014) A. Higa et al.   MOLECULAR AND CELLULAR BIOLOGY

A Synthetic Biology Approach Identifies the Mammalian UPR RNA Ligase RtcB

(2014) Yanyan Lu et al.   MOLECULAR CELL

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

Epithelial-Mesenchymal Transition Induces Endoplasmic-Reticulum-Stress Response in Human Colorectal Tumor Cells

(2014) Evelyn Zeindl-Eberhart et al.   PLoS One

Activating Transcription Factor 4 Promotes Esophageal Squamous Cell Carcinoma Invasion and Metastasis in Mice and Is Associated with Poor Prognosis in Human Patients

(2014) Hongwu Zhu et al.   PLoS One

Hyperoside, a Flavonoid Compound, Inhibits Proliferation and Stimulates Osteogenic Differentiation of Human Osteosarcoma Cells

(2014) Ning Zhang et al.   PLoS One

Interplay Between the Oxidoreductase PDIA6 and microRNA-322 Controls the Response to Disrupted Endoplasmic Reticulum Calcium Homeostasis

(2014) J. Groenendyk et al.   Science Signaling

MDA-9 and GRP78 as potential diagnostic biomarkers for early detection of melanoma metastasis

(2014) Ming Guan et al.   TUMOR BIOLOGY

Glucose-regulated protein 78 (GRP78) regulates colon cancer metastasis through EMT biomarkers and the NRF-2/HO-1 pathway

(2014) Yu-Jia Chang et al.   TUMOR BIOLOGY

Epithelial-to-Mesenchymal Transition Activates PERK-eIF2  and Sensitizes Cells to Endoplasmic Reticulum Stress

(2014) Y.-x. Feng et al.   Cancer Discovery

Invasion as target for therapy of glioblastoma multiforme

(2013) Anne Vehlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity

(2013) C. Atkins et al.   CANCER RESEARCH

Posttranscriptional Regulation of PER1 Underlies the Oncogenic Function of IRE 

(2013) O. Pluquet et al.   CANCER RESEARCH

Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface-Associated GRP78

(2013) Y. R. Miao et al.   CLINICAL CANCER RESEARCH

Hypoxic Activation of the PERK/eIF2  Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3

(2013) H. Mujcic et al.   CLINICAL CANCER RESEARCH

The role and regulation of blebs in cell migration

(2013) Ewa K Paluch et al.   CURRENT OPINION IN CELL BIOLOGY

Molecular networks in melanoma invasion and metastasis

(2013) Ewa Aladowicz et al.   Future Oncology

STAT3 silencing inhibits glioma single cell infiltration and tumor growth

(2013) M. Priester et al.   NEURO-ONCOLOGY

Cellular and molecular mechanisms controlling the migration of melanocytes and melanoma cells

(2013) Jacky Bonaventure et al.   Pigment Cell & Melanoma Research

Targeting Src Family Kinases Inhibits Bevacizumab-Induced Glioma Cell Invasion

(2013) Deborah Huveldt et al.   PLoS One

OASIS/CREB3L1 Is Induced by Endoplasmic Reticulum Stress in Human Glioma Cell Lines and Contributes to the Unfolded Protein Response, Extracellular Matrix Production and Cell Migration

(2013) Ravi N. Vellanki et al.   PLoS One

Baicalein Inhibits the Invasion and Metastatic Capabilities of Hepatocellular Carcinoma Cells via Down-Regulation of the ERK Pathway

(2013) Kunlun Chen et al.   PLoS One

Kaempferol Reduces Matrix Metalloproteinase-2 Expression by Down-Regulating ERK1/2 and the Activator Protein-1 Signaling Pathways in Oral Cancer Cells

(2013) Chiao-Wen Lin et al.   PLoS One

Cadherin switch from E- to N-cadherin in melanoma progression is regulated by the PI3K/PTEN pathway through Twist and Snail

(2012) L. Hao et al.   BRITISH JOURNAL OF DERMATOLOGY

The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway

(2012) Y. Wang et al.   CANCER RESEARCH

Syndecan and integrin interactomes: large complexes in small spaces

(2012) James A Roper et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The metastasis gene NEDD9 product acts through integrin  3 and Src to promote mesenchymal motility and inhibit amoeboid motility

(2012) J. Ahn et al.   JOURNAL OF CELL SCIENCE

Akt1 promotes focal adhesion disassembly and cell motility through phosphorylation of FAK in growth factor-stimulated cells

(2012) M. Higuchi et al.   JOURNAL OF CELL SCIENCE

Autocrine control of glioma cells adhesion and migration through IRE1 -mediated cleavage of SPARC mRNA

(2012) N. Dejeans et al.   JOURNAL OF CELL SCIENCE

FilGAP, a Rho/Rho-associated protein kinase–regulated GTPase-activating protein for Rac, controls tumor cell migration

(2012) Koji Saito et al.   MOLECULAR BIOLOGY OF THE CELL

Pharmacologic Blockade of FAK Autophosphorylation Decreases Human Glioblastoma Tumor Growth and Synergizes with Temozolomide

(2012) V. M. Golubovskaya et al.   MOLECULAR CANCER THERAPEUTICS

siRNA-mediated silencing of integrin β3 expression inhibits the metastatic potential of B16 melanoma cells

(2012) ANNA NASULEWICZ-GOLDEMAN et al.   ONCOLOGY REPORTS

Matrix metalloproteinase-2 Promotes αvβ3 Integrin-Mediated Adhesion and Migration of Human Melanoma Cells by Cleaving Fibronectin

(2012) Yang Jiao et al.   PLoS One

ER Stress Activates NF-κB by Integrating Functions of Basal IKK Activity, IRE1 and PERK

(2012) Arvin B. Tam et al.   PLoS One

New facets of matrix metalloproteinases MMP-2 and MMP-9 as cell surface transducers: Outside-in signaling and relationship to tumor progression

(2011) Brigitte Bauvois   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells

(2011) Bin Wu et al.   BMC CANCER

Hypoxic regulation and prognostic value of LAMP3 expression in breast cancer

(2011) Anika Nagelkerke et al.   CANCER

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress

(2011) T Rzymski et al.   ONCOGENE

Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

(2011) P. Tsaytler et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cells

(2010) Ling Wang et al.   CANCER LETTERS

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Rac and Rho GTPases in cancer cell motility control

(2010) Matteo Parri et al.   Cell Communication and Signaling

Determinants of leader cells in collective cell migration

(2010) Antoine A. Khalil et al.   Integrative Biology

IL-6 promotion of glioblastoma cell invasion and angiogenesis in U251 and T98G cell lines

(2010) Qinglin Liu et al.   JOURNAL OF NEURO-ONCOLOGY

Neuronal Apoptosis Induced by Endoplasmic Reticulum Stress Is Regulated by ATF4-CHOP-Mediated Induction of the Bcl-2 Homology 3-Only Member PUMA

(2010) Z. Galehdar et al.   JOURNAL OF NEUROSCIENCE

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

(2010) E Bobrovnikova-Marjon et al.   ONCOGENE

IL-6 augments the invasiveness of U87MG human glioblastoma multiforme cells via up-regulation of MMP-2 and fascin-1

(2010) Li   ONCOLOGY REPORTS

Inositol-requiring enzyme 1  is a key regulator of angiogenesis and invasion in malignant glioma

(2010) G. Auf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal Migration as a Therapeutic Target in Glioblastoma

(2010) Jessie Zhong et al.   Journal of Oncology

Activation and clinical significance of the unfolded protein response in breast cancer

(2009) P Scriven et al.   BRITISH JOURNAL OF CANCER

Proteolytic interstitial cell migration: a five-step process

(2009) Peter Friedl et al.   CANCER AND METASTASIS REVIEWS

Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients

(2009) K. V. Lu et al.   CANCER RESEARCH

The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells

(2009) K. Paňková et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ATF4, an ER Stress and Hypoxia-Inducible Transcription Factor and its Potential Role in Hypoxia Tolerance and Tumorigenesis

(2009) Jiangbin Ye et al.   CURRENT MOLECULAR MEDICINE

Mechanical modes of ‘amoeboid’ cell migration

(2009) Tim Lämmermann et al.   CURRENT OPINION IN CELL BIOLOGY

TAE226-mediated inhibition of focal adhesion kinase interferes with tumor angiogenesis and vasculogenesis

(2009) Alexander Schultze et al.   INVESTIGATIONAL NEW DRUGS

Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells

(2009) Ellen J. Ezratty et al.   JOURNAL OF CELL BIOLOGY

Dasatinib-induced autophagy is enhanced in combination with temozolomide in glioma

(2009) V. Milano et al.   MOLECULAR CANCER THERAPEUTICS

Collective cell migration in morphogenesis, regeneration and cancer

(2009) Peter Friedl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rac and Rho driving tumor invasion: who's at the wheel?

(2009) Marc Symons et al.   GENOME BIOLOGY

Quercetin inhibition of tumor invasion via suppressing PKC /ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells

(2008) C.-W. Lin et al.   CARCINOGENESIS

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

Cadherin switching

(2008) M. J. Wheelock et al.   JOURNAL OF CELL SCIENCE

The Role of Myosin II in Glioma Invasion of the Brain

(2008) Christopher Beadle et al.   MOLECULAR BIOLOGY OF THE CELL