Apigenin inhibits TNFα/IL-1α-induced CCL2 release through IKBK-epsilon signaling in MDA-MB-231 human breast cancer cells

Luteolin inhibits recruitment of monocytes and migration of Lewis lung carcinoma cells by suppressing chemokine (C–C motif) ligand 2 expression in tumor-associated macrophage

(2016) Hee-Jin Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatocellular Carcinoma Cells Induce Regulatory T Cells and Lead to Poor Prognosis via Production of Transforming Growth Factor-β1

(2016) Yi Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Tumor Necrosis Factor-α, a Regulator and Therapeutic Agent on Breast Cancer

(2016) Dongwu Liu et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Inflammatory cytokines prime adipose tissue mesenchymal stem cells to enhance malignancy of MCF-7 breast cancer cells via transforming growth factor-β1

(2016) Drenka Trivanović et al.   IUBMB LIFE

Macrophage and Cancer Cell Cross-talk via CCR2 and CX3CR1 Is a Fundamental Mechanism Driving Lung Cancer

(2015) Anja Schmall et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Apigenin and Breast Cancers: From Chemistry to Medicine

(2015) Seyed Nabavi et al.   Anti-Cancer Agents in Medicinal Chemistry

Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway

(2015) Chia-Hung Lin et al.   BMC CANCER

Antitumor and antimetastatic actions of dihydroxycoumarins (esculetin or fraxetin) through the inhibition of M2 macrophage differentiation in tumor-associated macrophages and/or G1 arrest in tumor cells

(2015) Yoshiyuki Kimura et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner

(2015) Kanae Yumimoto et al.   JOURNAL OF CLINICAL INVESTIGATION

CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages

(2015) Takanori Kitamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish

(2015) Chuan Yan et al.   JOURNAL OF HEPATOLOGY

Natural compounds for pediatric cancer treatment

(2015) Veronica Ferrucci et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Characterization of macrophage - cancer cell crosstalk in estrogen receptor positive and triple-negative breast cancer

(2015) Maija Hollmén et al.   Scientific Reports

Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF-α and the NF-κB pathway

(2015) Christina Katanov et al.   Stem Cell Research & Therapy

CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function

(2015) Eunyoung Chun et al.   Cell Reports

Suppression of NF-κB and NF-κB-Regulated Gene Expression by Apigenin through IκBα and IKK Pathway in TRAMP Mice

(2015) Sanjeev Shukla et al.   PLoS One

Exposure of breast cancer cells to a subcytotoxic dose of apigenin causes growth inhibition, oxidative stress, and hypophosphorylation of Akt

(2014) Megan E. Harrison et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The Measure of DAMPs and a role for S100A8 in recruiting suppressor cells in breast cancer lung metastasis

(2014) Christine N. Vrakas et al.   IMMUNOLOGICAL INVESTIGATIONS

Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth

(2014) Thanh U. Barbie et al.   JOURNAL OF CLINICAL INVESTIGATION

Tissue-Infiltrating Neutrophils Constitute the Major In Vivo Source of Angiogenesis-Inducing MMP-9 in the Tumor Microenvironment

(2014) Elena I. Deryugina et al.   NEOPLASIA

Breast tumor cell TACE-shed MCSF promotes pro-angiogenic macrophages through NF-κB signaling

(2013) Stephen L. Rego et al.   ANGIOGENESIS

Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization

(2013) Ji-Young Jang et al.   BMC CANCER

Apigenin up-regulates transgelin and inhibits invasion and migration of colorectal cancer through decreased phosphorylation of AKT

(2013) Li Chunhua et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Peroxisome Proliferator Activated Receptor-α/Hypoxia Inducible Factor-1α Interplay Sustains Carbonic Anhydrase IX and Apoliprotein E Expression in Breast Cancer Stem Cells

(2013) Alessio Papi et al.   PLoS One

IKKε-Mediated Tumorigenesis Requires K63-Linked Polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 Ubiquitin Ligase Complex

(2013) Alicia Y. Zhou et al.   Cell Reports

Linking tumor-associated macrophages, inflammation, and intestinal tumorigenesis: role of MCP-1

(2012) Jamie L. McClellan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models

(2012) Massimo Zollo et al.   CLINICAL & EXPERIMENTAL METASTASIS

Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells

(2012) Hye-Sook Seo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

I B Kinase   Phosphorylates TRAF2 To Promote Mammary Epithelial Cell Transformation

(2012) R. R. Shen et al.   MOLECULAR AND CELLULAR BIOLOGY

Apigenin Induces Apoptosis and Blocks Growth of Medroxyprogesterone Acetate-Dependent BT-474 Xenograft Tumors

(2012) Benford Mafuvadze et al.   Hormones & Cancer

Inflammatory mediators in breast cancer: Coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition

(2011) Gali Soria et al.   BMC CANCER

IKBKE Protein Activates Akt Independent of Phosphatidylinositol 3-Kinase/PDK1/mTORC2 and the Pleckstrin Homology Domain to Sustain Malignant Transformation

(2011) Jian-Ping Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Induction of apoptotic cell death by phytoestrogens by up-regulating the levels of phospho-p53 and p21 in normal and malignant estrogen receptor α–negative breast cells

(2011) Hye-Sook Seo et al.   NUTRITION RESEARCH

Synergistic Effects of Apigenin and Paclitaxel on Apoptosis of Cancer Cells

(2011) Yimiao Xu et al.   PLoS One

Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy

(2010) Pravin Mishra et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Apigenin blocks induction of vascular endothelial growth factor mRNA and protein in progestin-treated human breast cancer cells

(2010) Benford Mafuvadze et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Apigenin: A Promising Molecule for Cancer Prevention

(2010) Sanjeev Shukla et al.   PHARMACEUTICAL RESEARCH

Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression

(2009) Hiroshi Fujimoto et al.   INTERNATIONAL JOURNAL OF CANCER

Apigenin Induces Apoptosis through a Mitochondria/Caspase-Pathway in Human Breast Cancer MDA-MB-453 Cells

(2009) Eun Jeong Choi et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Apigenin causes G2/M arrest associated with the modulation of p21Cip1 and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells

(2008) Eun Jeong Choi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY