Unstable genomes elevate transcriptome dynamics

Single cell heterogeneity

(2013) Batoul Y Abdallah et al.   CELL CYCLE

Karyotype Heterogeneity and Unclassified Chromosomal Abnormalities

(2013) H.H.Q. Heng et al.   CYTOGENETIC AND GENOME RESEARCH

Heterogeneity of Cell Death

(2013) J.B. Stevens et al.   CYTOGENETIC AND GENOME RESEARCH

HeLa genome versus donor's genome

(2013) Henry H. Heng   NATURE

Revisiting Global Gene Expression Analysis

(2012) Jakob Lovén et al.   CELL

Genetic and Epigenetic Heterogeneity in Cancer: The Ultimate Challenge for Drug Therapy

(2012) H. H. Heng et al.   CURRENT DRUG TARGETS

Identification of osteosarcoma driver genes by integrative analysis of copy number and gene expression data

(2012) Marieke L. Kuijjer et al.   GENES CHROMOSOMES & CANCER

Why imatinib remains an exception of cancer research

(2012) Steven D. Horne et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Genomic analysis of a key innovation in an experimental Escherichia coli population

(2012) Zachary D. Blount et al.   NATURE

Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells

(2012) H Yasaei et al.   ONCOGENE

Transcriptional consequences of aneuploidy

(2012) J. M. Sheltzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Network analysis of reverse phase protein expression data: Characterizing protein signatures in acute myeloid leukemia cytogenetic categories t(8;21) and inv(16)

(2012) Heather York et al.   PROTEOMICS

Cancer Genetics With an Edge

(2012) J. Kaiser   SCIENCE

Karyotypic Determinants of Chromosome Instability in Aneuploid Budding Yeast

(2012) Jin Zhu et al.   PLoS Genetics

Effects of genome-wide copy number variation on expression in mammalian cells

(2011) Richard T Wang et al.   BMC GENOMICS

Decoding the genome beyond sequencing: The new phase of genomic research

(2011) Henry H.Q. Heng et al.   GENOMICS

Tumour evolution inferred by single-cell sequencing

(2011) Nicholas Navin et al.   NATURE

Deflating the Genomic Bubble

(2011) J. P. Evans et al.   SCIENCE

Diverse system stresses: common mechanisms of chromosome fragmentation

(2011) J B Stevens et al.   Cell Death & Disease

Most Random Gene Expression Signatures Are Significantly Associated with Breast Cancer Outcome

(2011) David Venet et al.   PLoS Computational Biology

SEX REDUCES GENETIC VARIATION: A MULTIDISCIPLINARY REVIEW

(2010) Root Gorelick et al.   EVOLUTION

Wild-type and Hupki (Human p53 Knock-in) Murine Embryonic Fibroblasts

(2010) Catherine Whibley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

(2010) Norman Pavelka et al.   NATURE

Missing heritability and stochastic genome alterations

(2010) Henry H. Q. Heng   NATURE REVIEWS GENETICS

Molecular changes in brain aging and Alzheimer's disease are mirrored in experimentally silenced cortical neuron networks

(2010) Marc Gleichmann et al.   NEUROBIOLOGY OF AGING

The genome-centric concept: resynthesis of evolutionary theory

(2009) Henry H. Q. Heng   BIOESSAYS

Systematic comparison of nonmelanoma skin cancer microarray datasets reveals lack of consensus genes

(2009) R. Van Haren et al.   BRITISH JOURNAL OF DERMATOLOGY

Genetic and epigenetic heterogeneity in cancer: A genome-centric perspective

(2009) Henry H.Q. Heng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Genome based cell population heterogeneity promotes tumorigenicity: The evolutionary mechanism of cancer

(2009) Christine J. Ye et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Functional proteomic profiling of AML predicts response and survival

(2008) S. M. Kornblau et al.   BLOOD

Meta-analysis of Colorectal Cancer Gene Expression Profiling Studies Identifies Consistently Reported Candidate Biomarkers

(2008) S. K. Chan et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor

(2008) Giulia Rancati et al.   CELL

Critical pathways in cellular senescence and immortalization revealed by gene expression profiling

(2008) A L Fridman et al.   ONCOGENE

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE