Review
Behavioral Sciences
Ryoki Sasaki, Shota Miyaguchi, Hideaki Onishi
Summary: Studies suggest that BDNF genotype may have a minor impact on individual motor performance and motor learning abilities.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Clinical Neurology
Leo Sher, Linda M. Bierer, Janine Flory, Iouri Makotkine, Rachel Yehuda
Summary: This study found that plasma BDNF levels were higher among combat veterans who made suicide attempts post-deployment compared to those who did not. BDNF may be involved in the pathophysiology of suicidal behavior in this population.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Veerta Sharma, Thakur Gurjeet Singh, Amarjot Kaur, Ashi Mannan, Sonia Dhiman
Summary: This article reviews the role and function of brain-derived neurotrophic factor (BDNF) and its receptor in the brain. It also highlights the importance of BDNF in various brain-related disorders.
NEUROCHEMICAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Margherita Maffei, Antonio Giordano
Summary: Leptin, produced by white adipose tissue, plays a crucial role in informing the brain about energy stores and regulating energy balance. Obesity-induced alterations in certain hubs of the hypothalamus may hinder the action of Leptin, leading to resistance in obese patients. Understanding how Leptin gains access to the brain and how neuronal plasticity interferes with its function may provide insights for enhancing the effects of Leptin.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Review
Behavioral Sciences
Ya-Hai Wang, Huan-Huan Zhou, Qiang Luo, Sidong Cui
Summary: This study investigated the effects of physical exercise on brain-derived neurotrophic factor (BDNF) in healthy individuals. The findings showed that both acute and long-term exercise had significant positive effects on circulating BDNF levels. Subgroup analysis revealed that long-term aerobic exercise, female participants, participants older than 60 years, and aerobic exercise contributed to a more pronounced improvement in BDNF levels.
BRAIN AND BEHAVIOR
(2022)
Review
Clinical Neurology
Sarah K. Ashcroft, Daniel D. Ironside, Liam Johnson, Suzanne S. Kuys, Angelica G. Thompson-Butel
Summary: This systematic review and meta-analysis of 17 studies found that high intensity aerobic exercise can increase circulating BDNF concentrations, which may contribute to increased neuroplasticity in individuals poststroke.
Article
Biology
Andonia Petkova-Tuffy, Nina Goedecke, Julio Viotti, Martin Korte, Thomas Dresbach
Summary: The study reveals that NL1 and BDNF act together to play a crucial role in synaptic maturation, including increasing the stability of active zones and recycling of synaptic vesicles, a process that relies on a transsynaptic pathway between them. Using BDNF can mimic the effects of NL1 overexpression on structural and functional maturation, while blocking BDNF signaling can prevent the effects of NL1 on presynaptic maturation.
Article
Cell & Tissue Engineering
Takashi Otsuka, Yuyo Maeda, Tomoyuki Kurose, Kei Nakagawa, Takafumi Mitsuhara, Yumi Kawahara, Louis Yuge
Summary: The study compared the therapeutic effects of MSCs derived from different tissues on chronic SCI model rats, finding that cranial bone-derived MSCs showed relatively higher expression of neurotrophic factors and improved motor function in chronic SCI model rats. Transplantation of cranial bone-derived MSCs enhanced expression of neurotrophic and neural plasticity factors in injured spinal cord tissue, demonstrating the efficacy of cranial bone-derived MSCs in cell-based therapy for chronic SCI.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Multidisciplinary Sciences
Panetha Pansri, Phetcharat Phanthong, Nopparat Suthprasertporn, Yindee Kitiyanant, Alisa Tubsuwan, Andras Dinnyes, Julianna Kobolak, Narisorn Kitiyanant
Summary: The study found that BDNF can promote cell proliferation of AD-derived hNPCs, but does not have a promoting effect on neurite outgrowth. The JAK2 inhibitor AG490 partially decreased BDNF-induced cell proliferation.
Article
Behavioral Sciences
Sagun Tiwari, Lili Qi, John Wong, Zhenxiang Han
Summary: According to a meta-analysis, peripheral levels of brain-derived neurotrophic factor (BDNF) significantly decrease in depression compared to nondepressed healthy controls. However, the study reveals significant heterogeneity among the included studies. Factors such as history of depression and alcohol consumption affect the level of BDNF, while age and gender do not impact the heterogeneity. Although decreased BDNF expression is a risk factor for depression, it cannot be used as a reliable biomarker to assess depression in clinical practice.
BRAIN AND BEHAVIOR
(2022)
Review
Clinical Neurology
Andrea Ballesio, Andrea Zagaria, Davide Gusmeo Curti, Rosalyn Moran, Peter J. Goadsby, Ivana Rosenzweig, Caterina Lombardo
Summary: The brain-derived neurotrophic factor (BDNF) is considered a transdiagnostic biomarker for mental disorders and is associated with emotional and cognitive functioning. A systematic review and meta-analysis of case-control studies were conducted to examine the levels of peripheral BDNF in individuals with insomnia. The results showed that subjects with insomnia had lower BDNF levels compared to healthy controls. However, the interpretation of the results should be cautious due to the small sample size, cross-sectional nature of the measurement, and high heterogeneity of the included data.
SLEEP MEDICINE REVIEWS
(2023)
Article
Multidisciplinary Sciences
Carlos Berlanga-Macias, Mairena Sanchez-Lopez, Montserrat Solera-Martinez, Ana Diez-Fernandez, Inmaculada Ballesteros-Yanez, Carlos A. Castillo-Sarmiento, Isabel A. Martinez-Ortega, Vicente Martinez-Vizcaino
Summary: This study found no significant positive association between exclusive breastfeeding and BDNF serum levels in Spanish schoolchildren aged eight to 11 years. Regardless of breastfeeding duration, age group, or sexual maturation, BDNF levels did not show significant differences, indicating that exclusive breastfeeding may not have a significant impact on BDNF levels in this age group.
Review
Medicine, General & Internal
Michal Piotrkowicz, Marlena Janoska-Jazdzik, Tytus Koweszko, Agata Szulc
Summary: Psychotherapy has been shown to lead to changes in brain structure and function, with BDNF identified as a potential research target. Limited studies indicate that BDNF concentration levels may increase after psychotherapy, but the impact of BDNF gene methylation status remains to be explored.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
Van Thuan Nguyen, Braxton Hill, Naiya Sims, Aaron Heck, Marcus Negron, Claire Lusk, Cristi L. Galindo
Summary: This article introduces the significance of brain-derived neurotrophic factor, which plays a crucial role in neurological disorders and various other biological functions.
NEURAL REGENERATION RESEARCH
(2023)
Article
Neurosciences
Shristi Khanal, Eugene Bok, Jaekwang Kim, Gyu Hwan Park, Dong-Young Choi
Summary: Parkinson's disease (PD) is a common neurodegenerative disease without known cure or therapy. Inosine, a purine nucleoside, can protect neuroblastoma cells and dopaminergic neurons through brain-derived neurotrophic factor (BDNF) upregulation and activation of its downstream signaling pathway. Adenosine receptors A1 and A2A play critical roles in mediating the neuroprotective effects of inosine. Inosine shows therapeutic potential in treating dopaminergic neurodegeneration in PD.
