Roles of Shiga Toxins in Immunopathology

Shigella infection in children under 5 years old in western French Guiana

(2018) M. Parisot et al.   EPIDEMIOLOGY AND INFECTION

Clathrin-independent endocytosis: an increasing degree of complexity

(2018) Kirsten Sandvig et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Strength of the association between antibiotic use and hemolytic uremic syndrome following Escherichia coli O157:H7 infection varies with case definition

(2018) Gillian A.M. Tarr et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Human monocytes stimulated by Shiga toxin 1a via globotriaosylceramide release proinflammatory molecules associated with hemolytic uremic syndrome

(2018) Maurizio Brigotti et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Membrane assembly of Shiga toxin glycosphingolipid receptors and toxin refractiveness of Madin-Darby canine kidney II epithelial cells

(2018) Nadine Legros et al.   JOURNAL OF LIPID RESEARCH

Shigellosis

(2018) Karen L Kotloff et al.   LANCET

Hemolytic uremic syndrome due to Shiga toxin-producing Escherichia coli infection

(2018) M. Bruyand et al.   MEDECINE ET MALADIES INFECTIEUSES

Pathogenic role of inflammatory response during Shiga toxin-associated hemolytic uremic syndrome (HUS)

(2018) Ramon Alfonso Exeni et al.   PEDIATRIC NEPHROLOGY

Vigilance or Subversion? Constitutive and Inducible M Cells in Mucosal Tissues

(2018) David D. Lo   TRENDS IN IMMUNOLOGY

CRISPR Screen Reveals that EHEC’s T3SS and Shiga Toxin Rely on Shared Host Factors for Infection

(2018) Alline R. Pacheco et al.   mBio

LPS-primed CD11b+ leukocytes serve as an effective carrier of Shiga toxin 2 to cause hemolytic uremic syndrome in mice

(2018) Shuo Niu et al.   Scientific Reports

Shiga toxin-glycosphingolipid interaction: Status quo of research with focus on primary human brain and kidney endothelial cells

(2018) Nadine Legros et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Diet-induced obesity precipitates kidney dysfunction and alters inflammatory mediators in mice treated with Shiga Toxin 2

(2018) Lisa M. Harrison et al.   MICROBIAL PATHOGENESIS

Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation

(2018) Songhai Tian et al.   PLOS BIOLOGY

Regulation of the Locus of Enterocyte Effacement in Attaching and Effacing Pathogens

(2017) R. Christopher D. Furniss et al.   JOURNAL OF BACTERIOLOGY

Haemolytic uraemic syndrome

(2017) Fadi Fakhouri et al.   LANCET

Neurological Involvement in Pediatric Hemolytic Uremic Syndrome: A Symptom-Oriented Analysis

(2017) Elif Özdoğan et al.   NEUROPEDIATRICS

Dexamethasone prevents motor deficits and neurovascular damage produced by shiga toxin 2 and lipopolysaccharide in the mouse striatum

(2017) Alipio Pinto et al.   NEUROSCIENCE

Blood-brain barrier-supported neurogenesis in healthy and diseased brain

(2017) Elena A. Pozhilenkova et al.   REVIEWS IN THE NEUROSCIENCES

Colonization, mortality, and host cytokines response to enterohemorrhagic Escherichia coli in rabbits

(2017) Mengjiao Guo et al.   Oncotarget

Microvesicle Involvement in Shiga Toxin-Associated Infection

(2017) et al.   Toxins

Shiga Toxins Induce Apoptosis and ER Stress in Human Retinal Pigment Epithelial Cells

(2017) Jun-Young Park et al.   Toxins

Shiga Toxin—A Model for Glycolipid-Dependent and Lectin-Driven Endocytosis

(2017) Ludger Johannes   Toxins

Shiga toxin of enterohaemorrhagicEscherichia colidirectly injures developing human erythrocytes

(2016) Josefine Betz et al.   CELLULAR MICROBIOLOGY

Emerging Public Health Challenges of Shiga Toxin–ProducingEscherichia coliRelated to Changes in the Pathogen, the Population, and the Environment

(2016) Mohamed A. Karmali   CLINICAL INFECTIOUS DISEASES

Shiga toxin glycosphingolipid receptors and their lipid membrane ensemble in primary human blood–brain barrier endothelial cells

(2016) Nadine Legros et al.   GLYCOBIOLOGY

Glycosylation abnormalities in Gdt1p/TMEM165 deficient cells result from a defect in Golgi manganese homeostasis

(2016) Sven Potelle et al.   HUMAN MOLECULAR GENETICS

Clearance of apoptotic neutrophils and resolution of inflammation

(2016) Mallary C. Greenlee-Wacker   IMMUNOLOGICAL REVIEWS

Shiga Toxins Trigger the Secretion of Lysyl-tRNA Synthetase to Enhance Proinflammatory Responses

(2016) Moo-Seung Lee et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Structures and Ribosomal Interaction of Ribosome-Inactivating Proteins

(2016) Wei-Wei Shi et al.   MOLECULES

Membrane invagination induced by Shiga toxin B-subunit: from molecular structure to tube formation

(2016) W. Pezeshkian et al.   Soft Matter

Bacterial Adrenergic Sensors Regulate Virulence of Enteric Pathogens in the Gut

(2016) Cristiano G. Moreira et al.   mBio

Shiga Toxins as Multi-Functional Proteins: Induction of Host Cellular Stress Responses, Role in Pathogenesis and Therapeutic Applications

(2016) Moo-Seung Lee et al.   Toxins

Tight Junction Disruption Induced by Type 3 Secretion System Effectors Injected by Enteropathogenic and Enterohemorrhagic Escherichia coli

(2016) Paul Ugalde-Silva et al.   Frontiers in Cellular and Infection Microbiology

Cytosolic Access of Intracellular Bacterial Pathogens: The Shigella Paradigm

(2016) Nora Mellouk et al.   Frontiers in Cellular and Infection Microbiology

Type Three Secretion System in Attaching and Effacing Pathogens

(2016) Meztlli O. Gaytán et al.   Frontiers in Cellular and Infection Microbiology

Endoplasmic Reticulum-Targeted Subunit Toxins Provide a New Approach to Rescue Misfolded Mutant Proteins and Revert Cell Models of Genetic Diseases

(2016) Humaira Adnan et al.   PLoS One

Association of haemolytic uraemic syndrome with dysregulation of chemokine receptor expression in circulating monocytes

(2015) Maria Victoria Ramos et al.   CLINICAL SCIENCE

The dynamic blood-brain barrier

(2015) James Keaney et al.   FEBS Journal

Shiga Toxins Activate the NLRP3 Inflammasome Pathway To Promote Both Production of the Proinflammatory Cytokine Interleukin-1β and Apoptotic Cell Death

(2015) Moo-Seung Lee et al.   INFECTION AND IMMUNITY

Shiga toxin glycosphingolipid receptors of Vero-B4 kidney epithelial cells and their membrane microdomain lipid environment

(2015) Daniel Steil et al.   JOURNAL OF LIPID RESEARCH

A Novel Mechanism of Bacterial Toxin Transfer within Host Blood Cell-Derived Microvesicles

(2015) Anne-lie Ståhl et al.   PLoS Pathogens

The Effects of Shiga Toxin 1, 2 and Their Subunits on Cytokine and Chemokine Expression by Human Macrophage-Like THP-1 Cells

(2015) Jeremy Brandelli et al.   Toxins

Carbohydrate Conformation and Lipid Condensation in Monolayers Containing Glycosphingolipid Gb3: Influence of Acyl Chain Structure

(2014) Erik B. Watkins et al.   BIOPHYSICAL JOURNAL

The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment

(2014) Emily M. Mallick et al.   CELLULAR MICROBIOLOGY

Actin Pedestal Formation by Enterohemorrhagic Escherichia coli Enhances Bacterial Host Cell Attachment and Concomitant Type III Translocation

(2014) Scott E. Battle et al.   INFECTION AND IMMUNITY

Differential Effects of Escherichia coli Subtilase Cytotoxin and Shiga Toxin 2 on Chemokine and Proinflammatory Cytokine Expression in Human Macrophage, Colonic Epithelial, and Brain Microvascular Endothelial Cell Lines

(2014) Hui Wang et al.   INFECTION AND IMMUNITY

Shiga toxins expressed by human pathogenic bacteria induce immune responses in host cells

(2014) Moo-Seung Lee et al.   JOURNAL OF MICROBIOLOGY

Direct acute tubular damage contributes to Shigatoxin-mediated kidney failure

(2014) Stefan Porubsky et al.   JOURNAL OF PATHOLOGY

Blinded by Shiga Toxin-Producing O104 Escherichia coli and Hemolytic Uremic Syndrome

(2014) Sjoukje E. Loudon et al.   JOURNAL OF PEDIATRICS

Shiga Toxin Promotes Podocyte Injury in Experimental Hemolytic Uremic Syndrome via Activation of the Alternative Pathway of Complement

(2014) M. Locatelli et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Neurological involvement in children with E. coli O104:H4-induced hemolytic uremic syndrome

(2014) Angela Bauer et al.   PEDIATRIC NEPHROLOGY

Glycolipid Binding Preferences of Shiga Toxin Variants

(2014) Sayali S. Karve et al.   PLoS One

Distinct Renal Pathology and a Chemotactic Phenotype after Enterohemorrhagic Escherichia coli Shiga Toxins in Non-Human Primate Models of Hemolytic Uremic Syndrome

(2013) Deborah J. Stearns-Kurosawa et al.   AMERICAN JOURNAL OF PATHOLOGY

Oral Intoxication of Mice with Shiga Toxin Type 2a (Stx2a) and Protection by Anti-Stx2a Monoclonal Antibody 11E10

(2013) L. M. Russo et al.   INFECTION AND IMMUNITY

Identification of TLR4 as the Receptor That Recognizes Shiga Toxins in Human Neutrophils

(2013) M. Brigotti et al.   JOURNAL OF IMMUNOLOGY

Antimicrobial resistance and genetic characteristics of integron-carrier shigellae isolated in Hungary (1998–2008)

(2013) Noémi Nógrády et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Interaction of Shiga toxin 2 with complement regulators of the factor H protein family

(2013) Kulwara Poolpol et al.   MOLECULAR IMMUNOLOGY

Current evidence for the role of complement in the pathogenesis of Shiga toxin haemolytic uraemic syndrome

(2013) Lindsay S. Keir et al.   PEDIATRIC NEPHROLOGY

Serine Protease EspP from Enterohemorrhagic Escherichia Coli Is Sufficient to Induce Shiga Toxin Macropinocytosis in Intestinal Epithelium

(2013) Julie In et al.   PLoS One

Thalamic involvement in patients with neurologic impairment due to Shiga toxin 2

(2012) Sven G. Meuth et al.   ANNALS OF NEUROLOGY

The neurological syndrome in adults during the 2011 northern German E. coli serotype O104:H4 outbreak

(2012) Tim Magnus et al.   BRAIN

Risk Factors for the Hemolytic Uremic Syndrome in Children Infected With Escherichia coli O157:H7: A Multivariable Analysis

(2012) C. S. Wong et al.   CLINICAL INFECTIOUS DISEASES

Promiscuous Shiga toxin 2e and its intimate relationship to Forssman

(2012) Johannes Müthing et al.   GLYCOBIOLOGY

Regulation of Cytokine and Chemokine Expression by the Ribotoxic Stress Response Elicited by Shiga Toxin Type 1 in Human Macrophage-Like THP-1 Cells

(2012) Dinorah Leyva-Illades et al.   INFECTION AND IMMUNITY

Multicenter Evaluation of a Sequence-Based Protocol for Subtyping Shiga Toxins and Standardizing Stx Nomenclature

(2012) F. Scheutz et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Renal and neurological involvement in typical Shiga toxin-associated HUS

(2012) Howard Trachtman et al.   Nature Reviews Nephrology

Estimates of Illnesses, Hospitalizations, and Deaths Caused By Major Bacterial Enteric Pathogens in Young Children in the United States

(2012) Elaine Scallan et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

A Novel Escherichia coli O157:H7 Clone Causing a Major Hemolytic Uremic Syndrome Outbreak in China

(2012) Yanwen Xiong et al.   PLoS One

Shiga Toxin 1 Induces on Lipopolysaccharide-Treated Astrocytes the Release of Tumor Necrosis Factor-alpha that Alter Brain-Like Endothelium Integrity

(2012) Verónica I. Landoni et al.   PLoS Pathogens

The Interactions of Human Neutrophils with Shiga Toxins and Related Plant Toxins: Danger or Safety?

(2012) Maurizio Brigotti   Toxins

Enterohemorrhagic Escherichia coli infection stimulates Shiga toxin 1 macropinocytosis and transcytosis across intestinal epithelial cells

(2011) Valeriy Lukyanenko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Bacteriophages carrying Shiga toxin genes: genomic variations, detection and potential treatment of pathogenic bacteria

(2011) Joanna M Łoś et al.   Future Microbiology

Differential Response of the Human Renal Proximal Tubular Epithelial Cell Line HK-2 to Shiga Toxin Types 1 and 2

(2011) Erin K. Lentz et al.   INFECTION AND IMMUNITY

Alternative Pathway Activation of Complement by Shiga Toxin Promotes Exuberant C3a Formation That Triggers Microvascular Thrombosis

(2011) M. Morigi et al.   JOURNAL OF IMMUNOLOGY

Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study

(2011) Martina Bielaszewska et al.   LANCET INFECTIOUS DISEASES

Open-Source Genomic Analysis of Shiga-Toxin–ProducingE. coliO104:H4

(2011) Holger Rohde et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epidemic Profile of Shiga-Toxin–ProducingEscherichia coliO104:H4 Outbreak in Germany

(2011) Christina Frank et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interactions with M Cells and Macrophages as Key Steps in the Pathogenesis of Enterohemorragic Escherichia coli Infections

(2011) Lucie Etienne-Mesmin et al.   PLoS One

Shiga Toxin Interaction with Human Intestinal Epithelium

(2011) Stephanie Schüller   Toxins

Shiga toxin 1 and ricin A chain bind to human polymorphonuclear leucocytes through a common receptor

(2010) Valentina Arfilli et al.   BIOCHEMICAL JOURNAL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Acute Neurological Involvement in Diarrhea-Associated Hemolytic Uremic Syndrome

(2010) S. Nathanson et al.   Clinical Journal of the American Society of Nephrology

Cytoskeleton-modulating effectors of enteropathogenic and enterohaemorrhagic Escherichia coli: Tir, EspFU and actin pedestal assembly

(2010) Kenneth G. Campellone   FEBS Journal

Toll-like receptor 4 facilitates binding of Shiga toxin to colon carcinoma and primary umbilical vein endothelial cells

(2010) Maria L. Torgersen et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Role of Tumor Necrosis Factor Alpha in Disease Using a Mouse Model of Shiga Toxin-Mediated Renal Damage

(2010) E. K. Lentz et al.   INFECTION AND IMMUNITY

Human Intestinal Tissue and Cultured Colonic Cells Contain Globotriaosylceramide Synthase mRNA and the Alternate Shiga Toxin Receptor Globotetraosylceramide

(2010) S. D. Zumbrun et al.   INFECTION AND IMMUNITY

A Major Fraction of Glycosphingolipids in Model and Cellular Cholesterol-containing Membranes Is Undetectable by Their Binding Proteins

(2010) Radhia Mahfoud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of integrin-linked kinase blocks podocyte epithelial–mesenchymal transition and ameliorates proteinuria

(2010) Young Sun Kang et al.   KIDNEY INTERNATIONAL

Clinical Relevance of Shiga Toxin Concentrations in the Blood of Patients With Hemolytic Uremic Syndrome

(2010) Maurizio Brigotti et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Intestinal damage in enterohemorrhagic Escherichia coli infection

(2010) Zivile D. Békássy et al.   PEDIATRIC NEPHROLOGY

Hemolytic Uremic Syndrome and Death in Persons withEscherichia coliO157:H7 Infection, Foodborne Diseases Active Surveillance Network Sites, 2000–2006

(2009) L. Hannah Gould et al.   CLINICAL INFECTIOUS DISEASES

Globotriaosyl ceramide receptor function - Where membrane structure and pathology intersect

(2009) C.A. Lingwood et al.   FEBS LETTERS

Shiga Toxin 1-Induced Inflammatory Response in Lipopolysaccharide-Sensitized Astrocytes Is Mediated by Endogenous Tumor Necrosis Factor Alpha

(2009) V. I. Landoni et al.   INFECTION AND IMMUNITY

Shiga Toxin Activates Complement and Binds Factor H: Evidence for an Active Role of Complement in Hemolytic Uremic Syndrome

(2009) Dorothea Orth et al.   JOURNAL OF IMMUNOLOGY

Host and pathogen determinants of verocytotoxin-producing Escherichia coli -associated hemolytic uremic syndrome

(2009) Mohamed A Karmali   KIDNEY INTERNATIONAL

Detergent-resistant globotriaosyl ceramide may define verotoxin/glomeruli-restricted hemolytic uremic syndrome pathology

(2009) Fahima Khan et al.   KIDNEY INTERNATIONAL

The QseC Adrenergic Signaling Cascade in Enterohemorrhagic E. coli (EHEC)

(2009) David T. Hughes et al.   PLoS Pathogens

Neuronal apoptosis and inflammatory responses in the central nervous system of a rabbit treated with Shiga toxin-2

(2008) Kiyomi Takahashi et al.   Journal of Neuroinflammation

Human colorectal tumors and metastases express Gb3 and can be targeted by an intestinal pathogen-based delivery tool

(2008) T. Falguieres et al.   MOLECULAR CANCER THERAPEUTICS