Mutations in hmg1, Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus

Cas9/CRISPR genome editing to demonstrate the contribution of Cyp51A Gly138Ser to azole resistance in Aspergillus fumigatus

(2018) Takashi Umeyama et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Epidemiology and risk factors for invasive fungal infections during induction chemotherapy for newly diagnosed acute myeloid leukemia: A retrospective cohort study

(2018) Ming-Yu Lien et al.   PLoS One

Triazole resistance in Aspergillus fumigatus: recent insights and challenges for patient management

(2018) Pieter P.A. Lestrade et al.   CLINICAL MICROBIOLOGY AND INFECTION

Epidemiology of invasive aspergillosis and azole resistance in patients with acute leukaemia: the SEPIA Study

(2017) Philipp Koehler et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Isolation of azole-resistant Aspergillus fumigatus from the environment in the south-eastern USA

(2017) Steven F. Hurst et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Evolution of cross-resistance to medical triazoles in Aspergillus fumigatus through selection pressure of environmental fungicides

(2017) Jianhua Zhang et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A Simple and Universal System for Gene Manipulation in Aspergillus fumigatus : In Vitro -Assembled Cas9-Guide RNA Ribonucleoproteins Coupled with Microhomology Repair Templates

(2017) Qusai Al Abdallah et al.   mSphere

Screening and Characterization of a Non- cyp51A Mutation in an Aspergillus fumigatus cox10 Strain Conferring Azole Resistance

(2016) Xiaolei Wei et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America

(2016) Thomas F. Patterson et al.   CLINICAL INFECTIOUS DISEASES

Emerging aspergillosis by azole-resistantAspergillus fumigatusat an intensive care unit in the Netherlands, 2010 to 2013

(2016) Judith van Paassen et al.   Eurosurveillance

Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial

(2016) Johan A Maertens et al.   LANCET

Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex

(2016) Fabio Gsaller et al.   PLoS Pathogens

Examination of cyp51A and cyp51B expression level of the first Polish azole resistant clinical Aspergillus fumigatus isolate

(2015) Anna Brillowska-Dąbrowska et al.   ACTA BIOCHIMICA POLONICA

In VitroBiochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus

(2015) Andrew G. S. Warrilow et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genotype–phenotype complexity of the TR46/Y121F/T289A cyp51A azole resistance mechanism in Aspergillus fumigatus

(2015) Eveline Snelders et al.   FUNGAL GENETICS AND BIOLOGY

Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) fromAspergillus fumigatusand Molecular Basis for the Development of Antifungal Drugs

(2015) Tatiana Y. Hargrove et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

First Detection of TR34 L98H and TR46 Y121F T289A Cyp51 Mutations in Aspergillus fumigatus Isolates in the United States

(2015) Nathan P. Wiederhold et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus’s Role in Virulence

(2015) Liliana Losada et al.   PLoS Pathogens

Aspergillus fumigatus harbouring the sole Y121F mutation shows decreased susceptibility to voriconazole but maintained susceptibility to itraconazole and posaconazole

(2014) J. Lescar et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Protter: interactive protein feature visualization and integration with experimental proteomic data

(2013) Ulrich Omasits et al.   BIOINFORMATICS

Contributions of Aspergillus fumigatus ATP-Binding Cassette Transporter Proteins to Drug Resistance and Virulence

(2013) Sanjoy Paul et al.   EUKARYOTIC CELL

The cdr1B efflux transporter is associated with non-cyp51a-mediated itraconazole resistance in Aspergillus fumigatus 

(2013) Marcin G. Fraczek et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

In vitro–in vivo correlation of voriconazole resistance due to G448S mutation (cyp51A gene) in Aspergillus fumigatus

(2012) S. Krishnan Natesan et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Analysis of Promoter Function in Aspergillus fumigatus

(2012) Sanjoy Paul et al.   EUKARYOTIC CELL

High-level expression of cyp51B in azole-resistant clinical Aspergillus fumigatus isolates

(2012) A. Buied et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Discovery of a hapE Mutation That Causes Azole Resistance in Aspergillus fumigatus through Whole Genome Sequencing and Sexual Crossing

(2012) Simone M. T. Camps et al.   PLoS One

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Invasive fungal disease in PICU: epidemiology and risk factors

(2012) Olivier Brissaud et al.   Annals of Intensive Care

Rapid Induction of Multiple Resistance Mechanisms in Aspergillus fumigatus during Azole Therapy: a Case Study and Review of the Literature

(2011) Simone M. T. Camps et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The structure–function relationship of the Aspergillus fumigatus cyp51A L98H conversion by site-directed mutagenesis: The mechanism of L98H azole resistance

(2011) Eveline Snelders et al.   FUNGAL GENETICS AND BIOLOGY

The Sterol-sensing Domain (SSD) Directly Mediates Signal-regulated Endoplasmic Reticulum-associated Degradation (ERAD) of 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase Isozyme Hmg2

(2011) Chandra L. Theesfeld et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus

(2011) S. Yasmin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional Regulation of Chitin Synthases by Calcineurin Controls Paradoxical Growth of Aspergillus fumigatus in Response to Caspofungin

(2010) J. R. Fortwendel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Wild-Type MIC Distribution and Epidemiological Cutoff Values for Aspergillus fumigatus and Three Triazoles as Determined by the Clinical and Laboratory Standards Institute Broth Microdilution Methods

(2009) M. A. Pfaller et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Insig Regulates HMG-CoA Reductase by Controlling Enzyme Phosphorylation in Fission Yeast

(2008) John S. Burg et al.   Cell Metabolism