Acetaminophen Responsive miR-19b Modulates SIRT1/Nrf2 Signaling Pathway in Drug-Induced Hepatotoxicity

SIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress

(2018) Patricia Rada et al.   ANTIOXIDANTS & REDOX SIGNALING

miR-19b-3p inhibits breast cancer cell proliferation and reverses saracatinib-resistance by regulating PI3K/Akt pathway

(2018) Juan Jin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Autophagy and acetaminophen-induced hepatotoxicity

(2018) Shulin Shan et al.   ARCHIVES OF TOXICOLOGY

Cerebroprotection by salvianolic acid B after experimental subarachnoid hemorrhage occurs via Nrf2- and SIRT1-dependent pathways

(2018) Xiangsheng Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

LncRNA ANRIL regulates AML development through modulating the glucose metabolism pathway of AdipoR1/AMPK/SIRT1

(2018) Lin-Yu Sun et al.   Molecular Cancer

SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

(2018) M. J. Vazquez et al.   Nature Communications

Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity

(2017) Kuo Du et al.   FOOD AND CHEMICAL TOXICOLOGY

Pterostilbene alleviates polymicrobial sepsis-induced liver injury: Possible role of SIRT1 signaling

(2017) Xiaojing Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Sirtuin 1 attenuates inflammation and hepatocellular damage in liver transplant ischemia/Reperfusion: From mouse to human

(2017) Kojiro Nakamura et al.   LIVER TRANSPLANTATION

Sirt1 Protects Endothelial Cells against LPS-Induced Barrier Dysfunction

(2017) Weijin Zhang et al.   Oxidative Medicine and Cellular Longevity

SRT1720 Alleviates ANIT-Induced Cholestasis in a Mouse Model

(2017) Linxi Yu et al.   Frontiers in Pharmacology

Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver

(2016) Ioannis Papageorgiou et al.   BIOCHEMICAL PHARMACOLOGY

Role of miRNA and its potential as a novel diagnostic biomarker in drug-induced liver injury

(2016) Sukumaran Sanjay et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

SIRT1 exerts protective effects against paraquat-induced injury in mouse type II alveolar epithelial cells by deacetylating NRF2 in vitro

(2016) YING-WEI DING et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

N -acetylcysteine amide, a promising antidote for acetaminophen toxicity

(2016) Ahdab Khayyat et al.   TOXICOLOGY LETTERS

Cellular localization of NRF2 determines the self-renewal and osteogenic differentiation potential of human MSCs via the P53–SIRT1 axis

(2016) D S Yoon et al.   Cell Death & Disease

Treatments for paracetamol poisoning

(2016) Nicholas A Buckley et al.   BMJ-British Medical Journal

Treatments for paracetamol poisoning

(2016) Nicholas A Buckley et al.   BMJ-British Medical Journal

Sirtuins Link Inflammation and Metabolism

(2016) Vidula T. Vachharajani et al.   Journal of Immunology Research

Hepatitis B Virus X Protein Induces Hepatic Steatosis by Enhancing the Expression of Liver Fatty Acid Binding Protein

(2015) Yun-li Wu et al.   JOURNAL OF VIROLOGY

Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1–p53 signaling pathways

(2015) Ying Wang et al.   TOXICOLOGY LETTERS

miR-19b regulates hTERT mRNA expression through targeting PITX1 mRNA in melanoma cells

(2015) Takahito Ohira et al.   Scientific Reports

The role of miR-19b in the inhibition of endothelial cell apoptosis and its relationship with coronary artery disease

(2015) Yong Tang et al.   Scientific Reports

Redox regulation of FoxO transcription factors

(2015) Lars-Oliver Klotz et al.   Redox Biology

SnapShot: Mammalian Sirtuins

(2014) Kristin A. Anderson et al.   CELL

A High-Fat Diet and NAD + Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome

(2014) Morten Scheibye-Knudsen et al.   Cell Metabolism

Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice

(2014) Dewei Ye et al.   HEPATOLOGY

SIRT1-Mediated Deacetylation of CRABPII Regulates Cellular Retinoic Acid Signaling and Modulates Embryonic Stem Cell Differentiation

(2014) Shuang Tang et al.   MOLECULAR CELL

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hopes and challenges in using miRNAs as translational biomarkers for drug-induced liver injury

(2013) Qiang Shi et al.   Biomarkers in Medicine

Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells

(2013) Kaipeng Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Deletion of SIRT1 From Hepatocytes in Mice Disrupts Lipin-1 Signaling and Aggravates Alcoholic Fatty Liver

(2013) Huquan Yin et al.   GASTROENTEROLOGY

Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21

(2013) Yu Li et al.   GASTROENTEROLOGY

Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits

(2013) Gordon F. Rushworth et al.   PHARMACOLOGY & THERAPEUTICS

A miR-19 regulon that controls NF-κB signaling

(2012) Michael P. Gantier et al.   NUCLEIC ACIDS RESEARCH

Negative regulation of inflammation by SIRT1

(2012) Jun Xie et al.   PHARMACOLOGICAL RESEARCH

FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression

(2011) E C Ferber et al.   CELL DEATH AND DIFFERENTIATION

SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress

(2010) Samuel Caito et al.   FASEB JOURNAL

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

(2010) Shinji Kume et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating microRNAs, potential biomarkers for drug-induced liver injury

(2009) K. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression

(2008) Kazuhiro Hasegawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sirt1 contributes critically to the redox-dependent fate of neural progenitors

(2008) Timour Prozorovski et al.   NATURE CELL BIOLOGY