Multisite Binding of a General Anesthetic to the Prokaryotic PentamericErwinia chrysanthemiLigand-gated Ion Channel (ELIC)

The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor

(2012) Andrew J. Thompson et al.   NEUROPHARMACOLOGY

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

(2012) R. Spurny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

General Anesthetics Predicted to Block the GLIC Pore with Micromolar Affinity

(2012) David N. LeBard et al.   PLoS Computational Biology

A Single Phenylalanine Residue in the Main Intracellular Loop of α1 γ-Aminobutyric Acid Type A and Glycine Receptors Influences Their Sensitivity to Propofol

(2011) Gustavo Moraga-Cid et al.   ANESTHESIOLOGY

Isoflurane Alters the Structure and Dynamics of GLIC

(2011) Dan Willenbring et al.   BIOPHYSICAL JOURNAL

Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels

(2011) Stuart A. Forman et al.   Canadian Journal of Anesthesia-Journal canadien d anesthesie

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

(2011) Hugues Nury et al.   NATURE

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

(2011) R. J. Howard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC

(2011) Iwan Zimmermann et al.   PLOS BIOLOGY

Anesthetic Binding in a Pentameric Ligand-Gated Ion Channel: GLIC

(2010) Qiang Chen et al.   BIOPHYSICAL JOURNAL

GABAA receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation

(2010) Richard W. Olsen et al.   Canadian Journal of Anesthesia-Journal canadien d anesthesie

Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel

(2010) Ricarda J C Hilf et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels

(2010) John E. Baenziger et al.   NEUROPHARMACOLOGY

Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain

(2010) G. Brannigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

General Anesthetics Have Additive Actions on Three Ligand Gated Ion Channels

(2009) Andrew Jenkins et al.   ANESTHESIA AND ANALGESIA

Anesthetic Sensitivity of the Gloeobacter violaceus Proton-Gated Ion Channel

(2009) Yun Weng et al.   ANESTHESIA AND ANALGESIA

What makes a molecule an anaesthetic? Studies on the mechanisms of anaesthesia using a physicochemical approach

(2009) J.W. Sear   BRITISH JOURNAL OF ANAESTHESIA

A prokaryotic perspective on pentameric ligand-gated ion channel structure

(2009) Ricarda JC Hilf et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development?

(2008) M Wallner et al.   BRITISH JOURNAL OF PHARMACOLOGY

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

Molecular targets underlying general anaesthesia

(2006) Nicholas P Franks   BRITISH JOURNAL OF PHARMACOLOGY