Alarmone Ap4A is elevated by aminoglycoside antibiotics and enhances their bactericidal activity

Bacterial cGAS-like enzymes synthesize diverse nucleotide signals

(2019) Aaron T. Whiteley et al.   NATURE

Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance

(2018) Wen Zhou et al.   CELL

Cellular Handling of Protein Aggregates by Disaggregation Machines

(2018) Axel Mogk et al.   MOLECULAR CELL

Direct activation of a phospholipase by cyclic GMP-AMP in El TorVibrio cholerae

(2018) Geoffrey B. Severin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

Analysis of global prevalence of antibiotic resistance in Acinetobacter baumannii infections disclosed a faster increase in OECD countries

(2018) Ruiqiang Xie et al.   Emerging Microbes & Infections

Studies on Aminoglycoside Susceptibility Identify a Novel Function of KsgA To Secure Translational Fidelity during Antibiotic Stress

(2018) Jin Zou et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance

(2018) Yingying Pu et al.   MOLECULAR CELL

Diadenosine tetraphosphate (Ap4A) - an E. coli alarmone or a damage metabolite?

(2017) Dragana Despotović et al.   FEBS Journal

Cyclic di-GMP: second messenger extraordinaire

(2017) Urs Jenal et al.   NATURE REVIEWS MICROBIOLOGY

Post-translational modification of HINT1 mediates activation of MITF transcriptional activity in human melanoma cells

(2017) A Motzik et al.   ONCOGENE

Importance of Core Genome Functions for an Extreme Antibiotic Resistance Trait

(2017) Larry A. Gallagher et al.   mBio

Stressed Mycobacteria Use the Chaperone ClpB to Sequester Irreversibly Oxidized Proteins Asymmetrically Within and Between Cells

(2015) Julien Vaubourgeix et al.   Cell Host & Microbe

Many Means to a Common End: the Intricacies of (p)ppGpp Metabolism and Its Control of Bacterial Homeostasis

(2015) Anthony O. Gaca et al.   JOURNAL OF BACTERIOLOGY

Biotin-c10-AppCH2ppA is an effective new chemical proteomics probe for diadenosine polyphosphate binding proteins

(2014) M. Ameruddin Azhar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Genomic Analysis Reveals Distinct Concentration-Dependent Evolutionary Trajectories for Antibiotic Resistance in Escherichia coli

(2014) Aalap Mogre et al.   DNA RESEARCH

Highly sensitive, selective and rapid LC–MS method for simultaneous quantification of diadenosine polyphosphates in human plasma

(2014) Anna Schulz et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Antibiotics induce redox-related physiological alterations as part of their lethality

(2014) D. J. Dwyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic Dinucleotides and the Innate Immune Response

(2013) Olga Danilchanka et al.   CELL

Chaperonins Fight Aminoglycoside-induced Protein Misfolding and Promote Short-term Tolerance inEscherichia coli

(2013) Lise Goltermann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolite damage and its repair or pre-emption

(2013) Carole L Linster et al.   Nature Chemical Biology

Multiple catalytic activities ofEscherichia colilysyl-tRNA synthetase (LysU) are dissected by site-directed mutagenesis

(2012) Xiaolong Chen et al.   FEBS Journal

Protein Aggregation Caused by Aminoglycoside Action Is Prevented by a Hydrogen Peroxide Scavenger

(2012) Jiqiang Ling et al.   MOLECULAR CELL

Identity and Function of a Large Gene Network Underlying Mutagenic Repair of DNA Breaks

(2012) A. A. M. Al Mamun et al.   SCIENCE

Isolation and identification of diadenosine 5′,5‴-P1,P4-tetraphosphate binding proteins using magnetic bio-panning

(2011) Wei Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pharmacological Considerations for the Proper Clinical Use of Aminoglycosides

(2011) Spyridon Pagkalis et al.   DRUGS

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Genome-Scale Identification of Resistance Functions in Pseudomonas aeruginosa Using Tn-seq

(2011) L. A. Gallagher et al.   mBio

Cellular strategies for controlling protein aggregation

(2010) Jens Tyedmers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge

(2009) Joo-Youn Cho et al.   JOURNAL OF LIPID RESEARCH

LysRS Serves as a Key Signaling Molecule in the Immune Response by Regulating Gene Expression

(2009) Nurit Yannay-Cohen et al.   MOLECULAR CELL

Role of Global Regulators and Nucleotide Metabolism in Antibiotic Tolerance in Escherichia coli

(2008) S. Hansen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mistranslation of Membrane Proteins and Two-Component System Activation Trigger Antibiotic-Mediated Cell Death

(2008) Michael A. Kohanski et al.   CELL