Studies on Aminoglycoside Susceptibility Identify a Novel Function of KsgA To Secure Translational Fidelity during Antibiotic Stress

Persistent bacterial infections and persister cells

(2017) Robert A. Fisher et al.   NATURE REVIEWS MICROBIOLOGY

Protein homeostasis — more than resisting a hot bath

(2016) Changhan Lee et al.   CURRENT OPINION IN MICROBIOLOGY

A Mutation in the 16S rRNA Decoding Region Attenuates the Virulence of Mycobacterium tuberculosis

(2016) Shinya Watanabe et al.   INFECTION AND IMMUNITY

Distinguishing between resistance, tolerance and persistence to antibiotic treatment

(2016) Asher Brauner et al.   NATURE REVIEWS MICROBIOLOGY

Genome-Wide Identification of Antimicrobial Intrinsic Resistance Determinants in Staphylococcus aureus

(2016) Martin Vestergaard et al.   Frontiers in Microbiology

16S rRNA methyltransferase KsgA contributes to oxidative stress resistance and virulence in Staphylococcus aureus

(2015) Tatsuhiko Kyuma et al.   BIOCHIMIE

What do we know about ribosomal RNA methylation in Escherichia coli?

(2015) O.V. Sergeeva et al.   BIOCHIMIE

Dimethyl Adenosine Transferase (KsgA) Deficiency in Salmonella enterica Serovar Enteritidis Confers Susceptibility to High Osmolarity and Virulence Attenuation in Chickens

(2013) Kim Lam Chiok et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Chaperonins Fight Aminoglycoside-induced Protein Misfolding and Promote Short-term Tolerance inEscherichia coli

(2013) Lise Goltermann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New antibiotic agents in the pipeline and how they can help overcome microbial resistance

(2013) Ian M. Gould et al.   Virulence

The Aminoglycoside Antibiotic Kanamycin Damages DNA Bases in Escherichia coli: Caffeine Potentiates the DNA-Damaging Effects of Kanamycin while Suppressing Cell Killing by Ciprofloxacin in Escherichia coli and Bacillus anthracis

(2012) Tina Manzhu Kang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Staphylococcus aureus and Escherichia coli have disparate dependences on KsgA for growth and ribosome biogenesis

(2012) Heather C O’Farrell et al.   BMC MICROBIOLOGY

Structural Insights into Methyltransferase KsgA Function in 30S Ribosomal Subunit Biogenesis

(2012) Daniel Boehringer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of Substrate Specificity by a Single Active Site Residue of the KsgA Methyltransferase

(2011) Heather C. O’Farrell et al.   BIOCHEMISTRY

Pharmacological Considerations for the Proper Clinical Use of Aminoglycosides

(2011) Spyridon Pagkalis et al.   DRUGS

Genome-Scale Identification of Resistance Functions in Pseudomonas aeruginosa Using Tn-seq

(2011) L. A. Gallagher et al.   mBio

Antibiotic Sensitivity Profiles Determined with an Escherichia coli Gene Knockout Collection: Generating an Antibiotic Bar Code

(2010) A. Liu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

The aminoglycoside resistance methyltransferases from the ArmA/Rmt family operate late in the 30S ribosomal biogenesis pathway

(2010) T. Zarubica et al.   RNA

Fine-tuning of the ribosomal decoding center by conserved methyl-modifications in the Escherichia coli 16S rRNA

(2009) Satoshi Kimura et al.   NUCLEIC ACIDS RESEARCH

KsgA, a 16S rRNA adenine methyltransferase, has a novel DNA glycosylase/AP lyase activity to prevent mutations in Escherichia coli

(2009) Q.-M. Zhang-Akiyama et al.   NUCLEIC ACIDS RESEARCH

Inactivation of KsgA, a 16S rRNA Methyltransferase, Causes Vigorous Emergence of Mutants with High-Level Kasugamycin Resistance

(2008) K. Ochi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mistranslation of Membrane Proteins and Two-Component System Activation Trigger Antibiotic-Mediated Cell Death

(2008) Michael A. Kohanski et al.   CELL

Mechanistic insight into the ribosome biogenesis functions of the ancient protein KsgA

(2008) Keith Connolly et al.   MOLECULAR MICROBIOLOGY