Novel insights into the development and maintenance of the blood–brain barrier

Studies of morphogens: keep calm and carry on

(2013) A. Stathopoulos et al.   DEVELOPMENT

Filopodia are dispensable for endothelial tip cell guidance

(2013) Li-Kun Phng et al.   DEVELOPMENT

Tbx1 regulates brain vascularization

(2013) Sara Cioffi et al.   HUMAN MOLECULAR GENETICS

Retinoic Acid Induces Blood-Brain Barrier Development

(2013) M. R. Mizee et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-Derived Sonic Hedgehog Contributes to Angiogenesis in Brain Microvascular Endothelial Cells via RhoA/ROCK Pathway After Oxygen–Glucose Deprivation

(2013) Quan-Wei He et al.   MOLECULAR NEUROBIOLOGY

LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling

(2013) Xiaomeng Wang et al.   NATURE

The embryonic mouse hindbrain as a qualitative and quantitative model for studying the molecular and cellular mechanisms of angiogenesis

(2013) Alessandro Fantin et al.   Nature Protocols

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recombinant Human Sonic Hedgehog Protein Regulates the Expression of ZO-1 and Occludin by Activating Angiopoietin-1 in Stroke Damage

(2013) Yuan-peng Xia et al.   PLoS One

Wnt Activation of Immortalized Brain Endothelial Cells as a Tool for Generating a Standardized Model of the Blood Brain Barrier In Vitro

(2013) Roberta Paolinelli et al.   PLoS One

Nogo-A is a negative regulator of CNS angiogenesis

(2013) T. Walchli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Laminin α5 guides tissue patterning and organogenesis

(2013) Caroline Spenlé et al.   Cell Adhesion & Migration

Radial Glial Neural Progenitors Regulate Nascent Brain Vascular Network Stabilization Via Inhibition of Wnt Signaling

(2013) Shang Ma et al.   PLOS BIOLOGY

Norrin/Frizzled4 Signaling in Retinal Vascular Development and Blood Brain Barrier Plasticity

(2012) Yanshu Wang et al.   CELL

In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains

(2012) Enrico Moro et al.   DEVELOPMENTAL BIOLOGY

Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation

(2012) Esther Steiner et al.   GLIA

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression

(2012) Marco Reis et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

(2012) Ethan S Lippmann et al.   NATURE BIOTECHNOLOGY

Wnt Proteins

(2012) K. Willert et al.   Cold Spring Harbor Perspectives in Biology

Barrier Mechanisms in the Developing Brain

(2012) Norman R. Saunders et al.   Frontiers in Pharmacology

Claudin-1 induced sealing of blood–brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis

(2011) Friederike Pfeiffer et al.   ACTA NEUROPATHOLOGICA

Coordinating cell behaviour during blood vessel formation

(2011) I. Geudens et al.   DEVELOPMENT

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

Deletion of aquaporin-4 changes the perivascular glial protein scaffold without disrupting the brain endothelial barrier

(2011) Martine Eilert-Olsen et al.   GLIA

Current concepts of blood-brain barrier development

(2011) Stefan Liebner et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Angiopoietin-1/Tie2 Signal Augments Basal Notch Signal Controlling Vascular Quiescence by Inducing Delta-Like 4 Expression through AKT-mediated Activation of β-Catenin

(2011) Jianghui Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interendothelial Claudin-5 Expression Depends on Cerebral Endothelial Cell–Matrix Adhesion by β1-Integrins

(2011) Takashi Osada et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells

(2011) Jeong-Ki Min et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor

(2011) Soo-Hyun Kim et al.   JOURNAL OF ENDOCRINOLOGY

Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei

(2011) Sandra Blaess et al.   Neural Development

Persistent Sonic Hedgehog Signaling in Adult Brain Determines Neural Stem Cell Positional Identity

(2011) Rebecca A. Ihrie et al.   NEURON

Inhibition of sonic hedgehog signaling aggravates brain damage associated with the down-regulation of Gli1, Ptch1 and SOD1 expression in acute ischemic stroke

(2011) Hui Ji et al.   NEUROSCIENCE LETTERS

Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet

(2011) N. N. Haj-Yasein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor

(2011) K. D. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier

(2011) M. Cullen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction

(2010) A. Fantin et al.   BLOOD

An Updated Overview on Wnt Signaling Pathways

(2010) Tata Purushothama Rao et al.   CIRCULATION RESEARCH

 -catenin deficiency causes DiGeorge syndrome-like phenotypes through regulation of Tbx1

(2010) S.-H. Huh et al.   DEVELOPMENT

The Wnt/β-Catenin Pathway Modulates Vascular Remodeling and Specification by Upregulating Dll4/Notch Signaling

(2010) Monica Corada et al.   DEVELOPMENTAL CELL

Medulloblastoma Comprises Four Distinct Molecular Variants

(2010) Paul A. Northcott et al.   JOURNAL OF CLINICAL ONCOLOGY

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells

(2010) Richard Daneman et al.   PLoS One

Essential Regulation of CNS Angiogenesis by the Orphan G Protein-Coupled Receptor GPR124

(2010) F. Kuhnert et al.   SCIENCE

Loss of astrocyte polarity marks blood–brain barrier impairment during experimental autoimmune encephalomyelitis

(2009) Karen Wolburg-Buchholz et al.   ACTA NEUROPATHOLOGICA

Neuromyelitis optica: Pathogenicity of patient immunoglobulin in vivo

(2009) Monika Bradl et al.   ANNALS OF NEUROLOGY

OR.81. Astrocyte-secreted Sonic Hedgehog Supports CNS Anti-inflammatory Activity and Promotes Optimal Human Blood Brain Barrier Functioning

(2009) Jorge Alvarez et al.   CLINICAL IMMUNOLOGY

Nrarp Coordinates Endothelial Notch and Wnt Signaling to Control Vessel Density in Angiogenesis

(2009) Li-Kun Phng et al.   DEVELOPMENTAL CELL

Angiogenesis: A Team Effort Coordinated by Notch

(2009) L.-K. Phng et al.   DEVELOPMENTAL CELL

Culture-Induced Changes in Blood—Brain Barrier Transcriptome: Implications for Amino-Acid Transporters in vivo

(2009) Ruth Lyck et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Wnt/ -catenin signaling is required for CNS, but not non-CNS, angiogenesis

(2009) R. Daneman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction

(2009) Britta Engelhardt et al.   Seminars in Immunopathology

Sonic Hedgehog Regulates Ischemia/Hypoxia-Induced Neural Progenitor Proliferation

(2009) John R. Sims et al.   STROKE

A Specialized Vascular Niche for Adult Neural Stem Cells

(2008) Masoud Tavazoie et al.   Cell Stem Cell

Adult SVZ Stem Cells Lie in a Vascular Niche: A Quantitative Analysis of Niche Cell-Cell Interactions

(2008) Qin Shen et al.   Cell Stem Cell

Wnt/β-catenin signaling controls development of the blood–brain barrier

(2008) Stefan Liebner et al.   JOURNAL OF CELL BIOLOGY

Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature

(2008) J. M. Stenman et al.   SCIENCE