Evaluating the Fitness Cost of Protein Expression in Saccharomyces cerevisiae

Electrostatic Mis-Interactions Cause Overexpression Toxicity of Proteins in E. coli

(2013) Gajinder Pal Singh et al.   PLoS One

Chaperones Divide Yeast Proteins into Classes of Expression Level and Evolutionary Rate

(2012) David Bogumil et al.   Genome Biology and Evolution

The Effect of Variation in the Effective Population Size on the Rate of Adaptive Molecular Evolution in Eukaryotes

(2012) Toni I. Gossmann et al.   Genome Biology and Evolution

Identification of dosage-sensitive genes in Saccharomyces cerevisiae using the genetic tug-of-war method

(2012) K. Makanae et al.   GENOME RESEARCH

Good Codons, Bad Transcript: Large Reductions in Gene Expression and Fitness Arising from Synonymous Mutations in a Key Enzyme

(2012) Deepa Agashe et al.   MOLECULAR BIOLOGY AND EVOLUTION

Evidence of non-random mutation rates suggests an evolutionary risk management strategy

(2012) Iñigo Martincorena et al.   NATURE

Protein misinteraction avoidance causes highly expressed proteins to evolve slowly

(2012) J.-R. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cost-Benefit Tradeoffs in Engineered lac Operons

(2012) M. Eames et al.   SCIENCE

ViennaRNA Package 2.0

(2011) Ronny Lorenz et al.   Algorithms for Molecular Biology

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

Cytosolic aggregates perturb the degradation of nontranslocated secretory and membrane proteins

(2011) Oishee Chakrabarti et al.   MOLECULAR BIOLOGY OF THE CELL

Non-adaptive origins of interactome complexity

(2011) Ariel Fernández et al.   NATURE

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Investment in rapid growth shapes the evolutionary rates of essential proteins

(2011) S. Vieira-Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive phenotypic analysis of single-gene deletion and overexpression strains of Saccharomyces cerevisiae

(2011) Katsunori Yoshikawa et al.   YEAST

Proteins Deleterious on Overexpression Are Associated with High Intrinsic Disorder, Specific Interaction Domains, and Low Abundance

(2010) Liang Ma et al.   JOURNAL OF PROTEOME RESEARCH

Impact of translational error-induced and error-free misfolding on the rate of protein evolution

(2010) Jian-Rong Yang et al.   Molecular Systems Biology

Synonymous but not the same: the causes and consequences of codon bias

(2010) Joshua B. Plotkin et al.   NATURE REVIEWS GENETICS

Evolutionary Systems Biology of Amino Acid Biosynthetic Cost in Yeast

(2010) Michael D. Barton et al.   PLoS One

Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast

(2010) K. A. Geiler-Samerotte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Comprehensive, Quantitative, and Genome-Wide Model of Translation

(2010) Marlena Siwiak et al.   PLoS Computational Biology

The rate of the molecular clock and the cost of gratuitous protein synthesis

(2010) Germán Plata et al.   GENOME BIOLOGY

Intrinsic Protein Disorder and Interaction Promiscuity Are Widely Associated with Dosage Sensitivity

(2009) Tanya Vavouri et al.   CELL

An atlas of chaperone–protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell

(2009) Yunchen Gong et al.   Molecular Systems Biology

Effective population size and patterns of molecular evolution and variation

(2009) Brian Charlesworth   NATURE REVIEWS GENETICS

Cellular mechanisms of membrane protein folding

(2009) William R Skach   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Coding-Sequence Determinants of Gene Expression in Escherichia coli

(2009) G. Kudla et al.   SCIENCE

Integrated Assessment of Genomic Correlates of Protein Evolutionary Rate

(2009) Yu Xia et al.   PLoS Computational Biology

Why Is the Correlation between Gene Importance and Gene Evolutionary Rate So Weak?

(2009) Zhi Wang et al.   PLoS Genetics

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

A quantitative estimation of the global translational activity in logarithmically growing yeast cells

(2008) Tobias von der Haar   BMC Systems Biology

Mistranslation-Induced Protein Misfolding as a Dominant Constraint on Coding-Sequence Evolution

(2008) D. Allan Drummond et al.   CELL

Function and structure of inherently disordered proteins

(2008) A Keith Dunker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

(2008) Konstanze F Winklhofer et al.   EMBO JOURNAL

The Cost of Expression of Escherichia coli lac Operon Proteins Is in the Process, Not in the Products

(2008) D. M. Stoebel et al.   GENETICS

Protein Folding and Misfolding on Surfaces

(2008) Massimo Stefani   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Population genomics of the wild yeast Saccharomyces paradoxus: Quantifying the life cycle

(2008) I. J. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein material costs: single atoms can make an evolutionary difference

(2008) Jason G. Bragg et al.   TRENDS IN GENETICS