Dehydrocostus Lactone Suppresses LPS-induced Acute Lung Injury and Macrophage Activation through NF-κB Signaling Pathway Mediated by p38 MAPK and Akt

Effects of Betaine on LPS-Stimulated Activation of Microglial M1/M2 Phenotypes by Suppressing TLR4/NF-κB Pathways in N9 Cells

(2019) Hui Shi et al.   MOLECULES

Effects of a combination of herbal extracts (modified Ojayeonjonghwan (Wuzi Yanzong wan)) on partial urethral obstruction-induced detrusor overactivity in rats: impact on the nitric oxide pathway and oxidative stress

(2019) Sangrak Bae et al.   BMC Complementary and Alternative Medicine

Isoalantolactone suppresses LPS-induced inflammation by inhibiting TRAF6 ubiquitination and alleviates acute lung injury

(2018) Yun-he Ding et al.   ACTA PHARMACOLOGICA SINICA

Dehydrocostus lactone induces prominent apoptosis in kidney distal tubular epithelial cells and interstitial fibroblasts along with cell cycle arrest in ovarian epithelial cells

(2018) Soma Shiva Nageswara Rao Singireesu et al.   BIOMEDICINE & PHARMACOTHERAPY

A Walk in Nature. Sesquiterpene Lactones as Multi-Target Agents Involved in Inflammatory Pathways

(2018) Adriana Coricello et al.   CURRENT MEDICINAL CHEMISTRY

Role of Human Macrophage Polarization in Inflammation during Infectious Diseases

(2018) Chiraz Atri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

miR-34b-5p inhibition attenuates lung inflammation and apoptosis in an LPS-induced acute lung injury mouse model by targeting progranulin

(2018) Wang Xie et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Role of Macrophages in the Pathogenesis of ALI/ARDS

(2018) Xiaofang Huang et al.   MEDIATORS OF INFLAMMATION

4-(Hydroxymethyl)catechol Extracted From Fungi in Marine Sponges Attenuates Rheumatoid Arthritis by Inhibiting PI3K/Akt/NF-κB Signaling

(2018) Jong Y. Lee et al.   Frontiers in Pharmacology

Regulatory T Cells and Acute Lung Injury: Cytokines, Uncontrolled Inflammation, and Therapeutic Implications

(2018) Shihui Lin et al.   Frontiers in Immunology

The Effect of C-Reactive Protein Isoforms on Nitric Oxide Production by U937 Monocytes/Macrophages

(2018) Nicola R. Sproston et al.   Frontiers in Immunology

MiR-135a Protects Vascular Endothelial Cells Against Ventilator-Induced Lung Injury by Inhibiting PHLPP2 to Activate PI3K/Akt Pathway

(2018) Xiaodi Yan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Apelin-13 Administration Protects Against LPS-Induced Acute Lung Injury by Inhibiting NF-κB Pathway and NLRP3 Inflammasome Activation

(2018) Hailin Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Barbaloin protects against lipopolysaccharide (LPS)-induced acute lung injury by inhibiting the ROS-mediated PI3K/AKT/NF-κB pathway

(2018) Kangfeng Jiang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Peiminine Protects against Lipopolysaccharide-Induced Mastitis by Inhibiting the AKT/NF-κB, ERK1/2 and p38 Signaling Pathways

(2018) Qian Gong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoxia Exacerbates Inflammatory Acute Lung Injury via the Toll-Like Receptor 4 Signaling Pathway

(2018) Gang Wu et al.   Frontiers in Immunology

Ruthenium pyridyl thiocyanate complex increased the production of pro-inflammatory TNFα and IL1β cytokines by the LPS stimulated mammalian macrophages in vitro

(2018) Furkan Ayaz   MOLECULAR BIOLOGY REPORTS

POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity

(2018) Li Zhang et al.   Nature Communications

Dehydrocostus Lactone Enhances Chemotherapeutic Potential of Doxorubicin in Lung Cancer by Inducing Cell Death and Limiting Metastasis

(2018) Wei Sheng et al.   MEDICAL SCIENCE MONITOR

Herbal Extracts and Natural Products in Alleviating Non-alcoholic Fatty Liver Disease via Activating Autophagy

(2018) Li Zhang et al.   Frontiers in Pharmacology

Icariside II attenuates lipopolysaccharide-induced neuroinflammation through inhibiting TLR4/MyD88/NF-κB pathway in rats

(2018) Jiayin Zhou et al.   BIOMEDICINE & PHARMACOTHERAPY

The Sesquiterpene Lactone, Budlein A, Inhibits Antigen-Induced Arthritis in Mice: Role of NF-κB and Cytokines

(2017) Ana C. Zarpelon et al.   INFLAMMATION

AKT2 Regulates Pulmonary Inflammation and Fibrosis via Modulating Macrophage Activation

(2017) Yunjuan Nie et al.   JOURNAL OF IMMUNOLOGY

p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection

(2017) Manoj B. Menon et al.   NATURE CELL BIOLOGY

Total tanshinones exhibits anti-inflammatory effects through blocking TLR4 dimerization via the MyD88 pathway

(2017) Hongwei Gao et al.   Cell Death & Disease

Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling cascade and NLRP3 inflammasome activation in mice

(2017) Xiaoping Luo et al.   Scientific Reports

Pivotal Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases

(2016) Feng Qian et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells

(2016) J G Cronin et al.   Mucosal Immunology

Papaverine inhibits lipopolysaccharide-induced microglial activation by suppressing NF-κB signaling pathway

(2016) Yalong Dang et al.   Drug Design Development and Therapy

Alterations of lung microbiota in a mouse model of LPS-induced lung injury

(2015) Valeriy Poroyko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Potential Anti-Cancer Activities and Mechanisms of Costunolide and Dehydrocostuslactone

(2015) Xuejing Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In vivo porcine lipopolysaccharide inflammation models to study immunomodulation of drugs

(2015) H. Wyns et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Arctigenin Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Rats

(2014) Xianbao Shi et al.   INFLAMMATION

Anti-inflammatory effects of cordycepin in lipopolysaccharide-stimulated RAW 264.7 macrophages through Toll-like receptor 4-mediated suppression of mitogen-activated protein kinases and NF-κB signaling pathways

(2014) Yung Hyun Choi et al.   Drug Design Development and Therapy

Comparative analysis of the alveolar macrophage proteome in ALI/ARDS patients between the exudative phase and recovery phase

(2013) Haiyun Dong et al.   BMC IMMUNOLOGY

Biomarkers of ALI/ARDS: Pathogenesis, Discovery, and Relevance to Clinical Trials

(2013) Lorraine Ware et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Map kinase phosphatase 5 protects against sepsis-induced acute lung injury

(2012) Feng Qian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Indoleamine 2,3-dioxygenase mediates anhedonia and anxiety-like behaviors caused by peripheral lipopolysaccharide immune challenge

(2012) Alexander Salazar et al.   HORMONES AND BEHAVIOR

The role of macrophages in healing the wounded lung

(2012) Andreas Alber et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Distinct Functions of the Mitogen-activated Protein Kinase-activated Protein (MAPKAP) Kinases MK2 and MK3

(2011) Christian Ehlting et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hexane Extract of Saussurea lappa and Its Active Principle, Dehydrocostus Lactone, Inhibit Prostate Cancer Cell Migration

(2011) Eun Ji Kim et al.   JOURNAL OF MEDICINAL FOOD

Protective effects of luteolin against lipopolysaccharide-induced acute lung injury involves inhibition of MEK/ERK and PI3K/Akt pathways in neutrophils

(2010) Jen-pei Lee et al.   ACTA PHARMACOLOGICA SINICA

The regulatory role of nitric oxide in proinflammatory cytokine expression during the induction and resolution of inflammation

(2010) Yoshiro Kobayashi   JOURNAL OF LEUKOCYTE BIOLOGY

New drugs for exacerbations of chronic obstructive pulmonary disease

(2009) Trevor T Hansel et al.   LANCET