AMPK activation induced in pemetrexed‐treated cells is associated with development of drug resistance independently of target enzyme expression

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

(2017) Chen-Song Zhang et al.   NATURE

The resistance related to targeted therapy in malignant pleural mesothelioma: Why has not the target been hit yet?

(2016) Giuseppe Bronte et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Targeting AMPK Signaling Pathway to Overcome Drug Resistance for Cancer Therapy

(2016) Zhiyu Wang et al.   CURRENT DRUG TARGETS

The double-edged sword of AMPK signaling in cancer and its therapeutic implications

(2015) Sang-Min Jeon et al.   ARCHIVES OF PHARMACAL RESEARCH

C6 ceramide sensitizes pemetrexed-induced apoptosis and cytotoxicity in osteosarcoma cells

(2014) Xinhui Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharmacological targeting of p53 through RITA is an effective antitumoral strategy for malignant pleural mesothelioma

(2014) Domenico Di Marzo et al.   CELL CYCLE

Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profile

(2014) Cristina Oliveras-Ferraros et al.   CELL CYCLE

Folliculin Regulates Ampk-Dependent Autophagy and Metabolic Stress Survival

(2014) Elite Possik et al.   PLoS Genetics

A chemical biology approach identifies AMPK as a modulator of melanoma oncogene MITF

(2013) V Borgdorff et al.   ONCOGENE

Molecular mechanism implicated in Pemetrexed-induced apoptosis in human melanoma cells

(2012) Aitziber Buqué et al.   Molecular Cancer

Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer

(2011) K Takezawa et al.   BRITISH JOURNAL OF CANCER

AMPK and Akt Determine Apoptotic Cell Death following Perturbations of One-Carbon Metabolism by Regulating ER Stress in Acute Lymphoblastic Leukemia

(2011) J. N. Kuznetsov et al.   MOLECULAR CANCER THERAPEUTICS

Pemetrexed induces both intrinsic and extrinsic apoptosis through ataxia telangiectasia mutated/p53-dependent and -independent signaling pathways

(2011) Tsung-Ying Yang et al.   MOLECULAR CARCINOGENESIS

Molecular mechanisms of cisplatin resistance

(2011) L Galluzzi et al.   ONCOGENE

SU11248 (sunitinib) directly inhibits the activity of mammalian 5'-AMP-activated protein kinase (AMPK)

(2010) Keith Laderoute et al.   CANCER BIOLOGY & THERAPY

Pemetrexed Indirectly Activates the Metabolic Kinase AMPK in Human Carcinomas

(2010) S. B. Rothbart et al.   CANCER RESEARCH

Therapeutics by Cytotoxic Metabolite Accumulation: Pemetrexed Causes ZMP Accumulation, AMPK Activation, and Mammalian Target of Rapamycin Inhibition

(2009) Alexandra C. Racanelli et al.   CANCER RESEARCH

AMP-activated protein kinase promotes human prostate cancer cell growth and survival

(2009) H. U. Park et al.   MOLECULAR CANCER THERAPEUTICS

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL