Pharmacological targeting of p53 through RITA is an effective antitumoral strategy for malignant pleural mesothelioma

The Worldwide Pandemic of Asbestos-Related Diseases

(2013) Leslie Stayner et al.   Annual Review of Public Health

A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis

(2013) M Kracikova et al.   CELL DEATH AND DIFFERENTIATION

The p53-reactivating small-molecule RITA enhances cisplatin-induced cytotoxicity and apoptosis in head and neck cancer

(2012) Jong-Lyel Roh et al.   CANCER LETTERS

IGF-1R/MDM2 Relationship Confers Enhanced Sensitivity to RITA in Ewing Sarcoma Cells

(2012) Giusy Di Conza et al.   MOLECULAR CANCER THERAPEUTICS

p53 Modulation as a Therapeutic Strategy in Gastrointestinal Stromal Tumors

(2012) Joern Henze et al.   PLoS One

High prevalence of serum antibodies reacting with simian virus 40 capsid protein mimotopes in patients affected by malignant pleural mesothelioma

(2012) E. Mazzoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA

(2011) Elisabeth Hedström et al.   CELL CYCLE

New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization

(2011) P Indovina et al.   ONCOGENE

Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1

(2011) A Ahmed et al.   Cell Death & Disease

Disruption of the MDM2–p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway

(2011) R Koster et al.   Cell Death & Disease

Rescue of the apoptotic-inducing function of mutant p53 by small molecule RITA

(2010) Carolyn Y. Zhao et al.   CELL CYCLE

Improving pharmacological rescue of p53 function: RITA targets mutant p53

(2010) Javier E. Girardini et al.   CELL CYCLE

The Case for a Global Ban on Asbestos

(2010) Joseph LaDou et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

RITA Inhibits Multiple Myeloma Cell Growth through Induction of p53-Mediated Caspase-Dependent Apoptosis and Synergistically Enhances Nutlin-Induced Cytotoxic Responses

(2010) M. N. Saha et al.   MOLECULAR CANCER THERAPEUTICS

Nutlin-3a Induces Cytoskeletal Rearrangement and Inhibits the Migration and Invasion Capacity of p53 Wild-Type Cancer Cells

(2010) Diarmuid M. Moran et al.   MOLECULAR CANCER THERAPEUTICS

Identification of Potential Therapeutic Targets in Malignant Mesothelioma Using Cell-Cycle Gene Expression Analysis

(2009) Solange Romagnoli et al.   AMERICAN JOURNAL OF PATHOLOGY

MicroRNA Signature of Malignant Mesothelioma with Potential Diagnostic and Prognostic Implications

(2009) Sara Busacca et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Ablation of Key Oncogenic Pathways by RITA-Reactivated p53 Is Required for Efficient Apoptosis

(2009) Vera V. Grinkevich et al.   CANCER CELL

MDM2-Dependent Downregulation of p21 and hnRNP K Provides a Switch between Apoptosis and Growth Arrest Induced by Pharmacologically Activated p53

(2009) Martin Enge et al.   CANCER CELL

HIPK2 Regulation by MDM2 Determines Tumor Cell Response to the p53-Reactivating Drugs Nutlin-3 and RITA

(2009) C. Rinaldo et al.   CANCER RESEARCH

Malignant Pleural Mesothelioma

(2009) Anne S. Tsao et al.   JOURNAL OF CLINICAL ONCOLOGY

Restoring p53 Function in Cancer: Novel Therapeutic Approaches for Applying the Brakes to Tumorigenesis

(2009) Alessandra Cintio et al.   Recent Patents on Anti-Cancer Drug Discovery

Enhanced Antitumor Therapy by Inhibition of p21waf1 in Human Malignant Mesothelioma

(2008) R. Lazzarini et al.   CLINICAL CANCER RESEARCH

Malignant Mesothelioma Resistance to Apoptosis: Recent Discoveries and their Implication for Effective Therapeutic Strategies

(2008) M. Rippo et al.   CURRENT MEDICINAL CHEMISTRY