Pemetrexed induces both intrinsic and extrinsic apoptosis through ataxia telangiectasia mutated/p53-dependent and -independent signaling pathways

Sustained activation of ERK and Cdk2/cyclin-A signaling pathway by pemetrexed leading to S-phase arrest and apoptosis in human non-small cell lung cancer A549 cells

(2011) Tsung-Ying Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Non-small-cell lung cancer: ESMO Clinical Recommendations for diagnosis, treatment and follow-up

(2009) G. D'Addario et al.   ANNALS OF ONCOLOGY

Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair

(2009) E. Bolderson et al.   CLINICAL CANCER RESEARCH

Emodin induces a reactive oxygen species-dependent and ATM-p53-Bax mediated cytotoxicity in lung cancer cells

(2009) Jin-Mei Lai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study

(2009) Tudor Ciuleanu et al.   LANCET

Divergence to apoptosis from ROS induced cell cycle arrest: Effect of cadmium

(2009) Soumya Chatterjee et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

PUMA, a potent killer with or without p53

(2009) J Yu et al.   ONCOGENE

An epidermal growth factor inhibitor, Gefitinib, induces apoptosis through a p53-dependent upregulation of pro-apoptotic molecules and downregulation of anti-apoptotic molecules in human lung adenocarcinoma A549 cells

(2008) Gee-Chen Chang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non–Small-Cell Lung Cancer

(2008) Giorgio Vittorio Scagliotti et al.   JOURNAL OF CLINICAL ONCOLOGY

DNA Damage Response Pathways in Tumor Suppression and Cancer Treatment

(2008) Yulong Liang et al.   WORLD JOURNAL OF SURGERY

Central role of mitochondria and p53 in PUVA-induced apoptosis in human keratinocytes cell line NCTC-2544

(2007) Giampietro Viola et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY