Evaluation of Neuropathological Effects of a High-Fat Diet in a Presymptomatic Alzheimer’s Disease Stage in APP/PS1 Mice

The Alzheimer's Disease Mitochondrial Cascade Hypothesis

(2017) Russell H. Swerdlow et al.   JOURNAL OF ALZHEIMERS DISEASE

Interplay between exercise and dietary fat modulates myelinogenesis in the central nervous system

(2016) Hyesook Yoon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Insulin resistance predicts brain amyloid deposition in late middle-aged adults

(2015) Auriel A. Willette et al.   Alzheimers & Dementia

High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents

(2015) Dmitry Petrov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hippocampal signaling pathways are involved in stress-induced impairment of memory formation in rats

(2015) Maryam Sardari et al.   BRAIN RESEARCH

The Role of PGC-1α in the Development of Insulin Resistance in Skeletal Muscle - Revisited

(2015) Bartlomiej Łukaszuk et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Metabolic roles of PGC-1α and its implications for type 2 diabetes

(2015) A. Besseiche et al.   DIABETES & METABOLISM

PPARα Signaling in the Hippocampus: Crosstalk Between Fat and Memory

(2015) Avik Roy et al.   Journal of Neuroimmune Pharmacology

Models and mechanisms for hippocampal dysfunction in obesity and diabetes

(2015) A.M. Stranahan   NEUROSCIENCE

Synaptic Therapy in Alzheimer’s Disease: A CREB-centric Approach

(2015) Andrew F. Teich et al.   Neurotherapeutics

The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain

(2015) Paul Saftig et al.   PROGRESS IN NEUROBIOLOGY

Central vascular disease and exacerbated pathology in a mixed model of type 2 diabetes and Alzheimer's disease

(2015) Juan Jose Ramos-Rodriguez et al.   PSYCHONEUROENDOCRINOLOGY

Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle–Aged Adults at Risk for Alzheimer Disease

(2015) Auriel A. Willette et al.   JAMA Neurology

Microglial dysfunction in brain aging and Alzheimer's disease

(2014) Kira Irving Mosher et al.   BIOCHEMICAL PHARMACOLOGY

Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease

(2014) Ignacio Pedrós et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain

(2014) D. Allan Butterfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Functional roles of CREB as a positive regulator in the formation and enhancement of memory

(2014) Satoshi Kida et al.   BRAIN RESEARCH BULLETIN

Insulin-Degrading Enzyme: A Link Between Alzheimer’s and Type 2 Diabetes Mellitus

(2014) Rizwanul Haque et al.   CNS & Neurological Disorders-Drug Targets

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

(2014) F. G. De Felice et al.   DIABETES

Short-Term High-Fat-and-Fructose Feeding Produces Insulin Signaling Alterations Accompanied by Neurite and Synaptic Reduction and Astroglial Activation in the Rat Hippocampus

(2014) Erika Calvo-Ochoa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014

(2014) L. S. Schneider et al.   JOURNAL OF INTERNAL MEDICINE

High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status

(2014) Mari Takalo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Preventing Alzheimer's disease by means of natural selection

(2014) L. A. Demetrius et al.   Journal of the Royal Society Interface

High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology

(2014) Elysse M. Knight et al.   NEUROBIOLOGY OF AGING

Insulin resistance in Alzheimer's disease

(2014) Kelly T. Dineley et al.   NEUROBIOLOGY OF DISEASE

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

(2014) Steven E. Arnold et al.   NEUROBIOLOGY OF DISEASE

Prediabetes-induced vascular alterations exacerbate central pathology in APPswe/PS1dE9 mice

(2014) Juan Jose Ramos-Rodriguez et al.   PSYCHONEUROENDOCRINOLOGY

Neuronal failure in Alzheimer’s disease: a view through the oxidative stress looking-glass

(2014) David J. Bonda et al.   Neuroscience Bulletin

Reduced amyloid-β degradation in early Alzheimer's disease but not in the APPswePS1dE9 and 3xTg-AD mouse models

(2013) Anita Stargardt et al.   AGING CELL

Alzheimer’s as a metabolic disease

(2013) Lloyd A. Demetrius et al.   BIOGERONTOLOGY

Senescent-induced dysregulation of cAMP/CREB signaling and correlations with cognitive decline

(2013) Rolf T. Hansen et al.   BRAIN RESEARCH

The effect of high fat diet and saturated fatty acids on insulin signaling in the amygdala and hypothalamus of rats

(2013) Hyoungil Oh et al.   BRAIN RESEARCH

Hyperphosphorylation of Tau Protein in Hippocampus of Central Insulin-Resistant Rats is Associated with Cognitive Impairment

(2013) Dantao Peng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

(2013) Fernanda G. De Felice   JOURNAL OF CLINICAL INVESTIGATION

Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease

(2013) Willem Kamphuis et al.   NEUROBIOLOGY OF AGING

ADAM10 in Synaptic Physiology and Pathology

(2013) Stefano Musardo et al.   Neurodegenerative Diseases

Molecular links between Alzheimer’s disease and diabetes mellitus

(2013) Y. Yang et al.   NEUROSCIENCE

Genetic mouse models of brain ageing and Alzheimer's disease

(2013) Andras Bilkei-Gorzo   PHARMACOLOGY & THERAPEUTICS

ERK and p38 inhibitors attenuate memory deficits and increase CREB phosphorylation and PGC-1α levels in Aβ-injected rats

(2012) Ghorbangol Ashabi et al.   BEHAVIOURAL BRAIN RESEARCH

Detrimental Effects of Diet-Induced Obesity on   Pathology Are Independent of Insulin Resistance in   Transgenic Mice

(2012) A. Leboucher et al.   DIABETES

Insulin Has Multiple Antiamyloidogenic Effects on Human Neuronal Cells

(2012) Giuseppe Pandini et al.   ENDOCRINOLOGY

Early memory deficits precede plaque deposition in APPswe/PS1dE9 mice: Involvement of oxidative stress and cholinergic dysfunction

(2012) Wei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Juvenile, but not adult exposure to high-fat diet impairs relational memory and hippocampal neurogenesis in mice

(2012) Chloe Boitard et al.   HIPPOCAMPUS

PGC1  and mitochondrial metabolism - emerging concepts and relevance in ageing and neurodegenerative disorders

(2012) S. Austin et al.   JOURNAL OF CELL SCIENCE

PGC-1  Negatively Regulates Extrasynaptic NMDAR Activity and Excitotoxicity

(2012) C. Puddifoot et al.   JOURNAL OF NEUROSCIENCE

RETRACTED: Multiple inflammatory pathways are involved in the development and progression of cognitive deficits in APPswe/PS1dE9 mice

(2012) Wei Zhang et al.   NEUROBIOLOGY OF AGING

Amyloid Precursor Protein and Proinflammatory Changes Are Regulated in Brain and Adipose Tissue in a Murine Model of High Fat Diet-Induced Obesity

(2012) Kendra L. Puig et al.   PLoS One

Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines

(2012) Aiwu Cheng et al.   Nature Communications

The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB

(2012) Eric R Kandel   Molecular Brain

Mitochondria and Cell Bioenergetics: Increasingly Recognized Components and a Possible Etiologic Cause of Alzheimer's Disease

(2011) Russell H. Swerdlow   ANTIOXIDANTS & REDOX SIGNALING

Soluble Aβ levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease

(2011) Wei Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease

(2011) Baiyang Sheng et al.   JOURNAL OF NEUROCHEMISTRY

β-Apptists and Tauists, it is time for a sermon from the book of biogenesis

(2011) Russell H. Swerdlow   JOURNAL OF NEUROCHEMISTRY

Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function

(2011) Shuko Takeda et al.   Molecular BioSystems

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

(2010) J. E. Ayala et al.   Disease Models & Mechanisms

Upregulation of the α-secretase ADAM10 - risk or reason for hope?

(2010) Kristina Endres et al.   FEBS Journal

Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model

(2010) Xu Wang et al.   Molecular Neurodegeneration

Myelination and the trophic support of long axons

(2010) Klaus-Armin Nave   NATURE REVIEWS NEUROSCIENCE

PGC-1α Expression Decreases in the Alzheimer Disease Brain as a Function of Dementia

(2009) Weiping Qin et al.   ARCHIVES OF NEUROLOGY

Gender-dependent oxidative variations in liver of aged rats

(2009) Seval Aydın et al.   BIOGERONTOLOGY

Modifiers of cognitive function and brain structure in middle-aged and elderly individuals with type 2 diabetes mellitus

(2009) Hannah Bruehl et al.   BRAIN RESEARCH

Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP × PS1 knock-in mice

(2008) Christa M. Studzinski et al.   JOURNAL OF NEUROCHEMISTRY

Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis

(2008) M. A. Beydoun et al.   Obesity Reviews

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL