IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease

Intestinal fibrosis is associated with lack of response to Infliximab therapy in Crohn's disease

(2018) Jessica R. de Bruyn et al.   PLoS One

IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates

(2018) Lyssia Belarif et al.   Nature Communications

Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency

(2017) Yannick Simoni et al.   IMMUNITY

Crohn's disease

(2017) Joana Torres et al.   LANCET

Ulcerative colitis

(2017) Ryan Ungaro et al.   LANCET

Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease

(2017) Nathaniel R West et al.   NATURE MEDICINE

Compartment-specific distribution of human intestinal innate lymphoid cells is altered in HIV patients under effective therapy

(2017) Benjamin Krämer et al.   PLoS Pathogens

Distinct Gene Regulatory Pathways for Human Innate versus Adaptive Lymphoid Cells

(2016) Olivia I. Koues et al.   CELL

Effect of vedolizumab (anti-α4β7-integrin) therapy on histological healing and mucosal gene expression in patients with UC

(2016) Ingrid Arijs et al.   GUT

The heterogeneity of human CD127+ innate lymphoid cells revealed by single-cell RNA sequencing

(2016) Åsa K Björklund et al.   NATURE IMMUNOLOGY

A pathogenic role for T cell–derived IL-22BP in inflammatory bowel disease

(2016) Penelope Pelczar et al.   SCIENCE

Receptor occupancy and blocking of STAT5 signaling by an anti-IL-7 receptor α antibody in cynomolgus monkeys

(2015) Brent Kern et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo

(2015) Anika Fischer et al.   GUT

Interleukin-7 Produced by Intestinal Epithelial Cells in Response to Citrobacter rodentium Infection Plays a Major Role in Innate Immunity against This Pathogen

(2015) Wei Zhang et al.   INFECTION AND IMMUNITY

Strong Upregulation of AIM2 and IFI16 Inflammasomes in the Mucosa of Patients with Active Inflammatory Bowel Disease

(2015) Wiebe Vanhove et al.   INFLAMMATORY BOWEL DISEASES

Dichotomy of short and long thymic stromal lymphopoietin isoforms in inflammatory disorders of the bowel and skin

(2015) Giulia Fornasa et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Blockade of CD127 Exerts a Dichotomous Clinical Effect in Marmoset Experimental Autoimmune Encephalomyelitis

(2015) Jordon Dunham et al.   Journal of Neuroimmune Pharmacology

Regulatory T-cell depletion in the gut caused by integrin β7 deficiency exacerbates DSS colitis by evoking aberrant innate immunity

(2015) H L Zhang et al.   Mucosal Immunology

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

The unusual suspects—innate lymphoid cells as novel therapeutic targets in IBD

(2015) Rimma Goldberg et al.   Nature Reviews Gastroenterology & Hepatology

Immunopathogenesis of IBD: current state of the art

(2015) Heitor S. P. de Souza et al.   Nature Reviews Gastroenterology & Hepatology

Guiding Postablative Lymphocyte Reconstitution as a Route Toward Transplantation Tolerance

(2014) G. Piotti et al.   AMERICAN JOURNAL OF TRANSPLANTATION

IL-7 receptor blockade following T cell depletion promotes long-term allograft survival

(2014) Hoa-Le Mai et al.   JOURNAL OF CLINICAL INVESTIGATION

Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature

(2014) Yael Haberman et al.   JOURNAL OF CLINICAL INVESTIGATION

The short form of TSLP is constitutively translated in human keratinocytes and has characteristics of an antimicrobial peptide

(2014) L Bjerkan et al.   Mucosal Immunology

Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells

(2014) G Bakdash et al.   Mucosal Immunology

Decreases in Colonic and Systemic Inflammation in Chronic HIV Infection after IL-7 Administration

(2014) Irini Sereti et al.   PLoS Pathogens

RORγt+ Innate Lymphoid Cells Acquire a Proinflammatory Program upon Engagement of the Activating Receptor NKp44

(2013) Timor Glatzer et al.   IMMUNITY

Interleukin-7: Fuel for the autoimmune attack

(2013) Hans Dooms   JOURNAL OF AUTOIMMUNITY

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

(2013) Jochem H Bernink et al.   NATURE IMMUNOLOGY

Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis

(2013) Brian G. Feagan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease

(2013) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Genome-Wide Screen of CREB Occupancy Identifies the RhoA Inhibitors Par6C and Rnd3 as Regulators of BDNF-Induced Synaptogenesis

(2013) Adam Lesiak et al.   PLoS One

Soluble IL7R  potentiates IL-7 bioactivity and promotes autoimmunity

(2013) W. Lundstrom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preclinical Efficacy and Immunological Safety of FR104, an Antagonist Anti-CD28 Monovalent Fab′ Antibody

(2012) N. Poirier et al.   AMERICAN JOURNAL OF TRANSPLANTATION

IL-7 induces expression and activation of integrin  4 7 promoting naive T-cell homing to the intestinal mucosa

(2012) R. Cimbro et al.   BLOOD

Transcriptional analysis of the intestinal mucosa of patients with ulcerative colitis in remission reveals lasting epithelial cell alterations

(2012) Núria Planell et al.   GUT

Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells

(2012) Yasuhiro Nemoto et al.   GUT

The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor+ Innate Lymphoid Cells

(2012) Nick Powell et al.   IMMUNITY

Whatʼs the next best cytokine target in IBD?

(2012) Thomas T. MacDonald et al.   INFLAMMATORY BOWEL DISEASES

Interleukin-7 receptor blockade suppresses adaptive and innate inflammatory responses in experimental colitis

(2012) Cynthia R Willis et al.   Journal of Inflammation-London

Crohn's disease

(2012) Daniel C Baumgart et al.   LANCET

Interleukin-7 Links T Lymphocyte and Intestinal Epithelial Cell Homeostasis

(2012) Shabnam Shalapour et al.   PLoS One

IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis

(2012) Florent Carrette et al.   SEMINARS IN IMMUNOLOGY

Gene Expression Profiling and Response Signatures Associated With Differential Responses to Infliximab Treatment in Ulcerative Colitis

(2011) Gary Toedter et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis

(2011) James C. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Upregulated IL-7 Receptor   Expression on Colitogenic Memory CD4+ T Cells May Participate in the Development and Persistence of Chronic Colitis

(2011) T. Shinohara et al.   JOURNAL OF IMMUNOLOGY

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

(2011) Carl A Anderson et al.   NATURE GENETICS

Ulcerative Colitis

(2011) Silvio Danese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Commensal microflora and interferon-γ promote steady-state interleukin-7 production in vivo

(2010) Shabnam Shalapour et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: Definitions, frequency and pharmacological aspects

(2010) Matthieu Allez et al.   Journal of Crohns & Colitis

The role of IL-1β in reduced IL-7 production by stromal and epithelial cells: a model for impaired T-cell numbers in the gut during HIV-1 infection

(2010) P. H. Thang et al.   JOURNAL OF INTERNAL MEDICINE

Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells

(2010) S G Kang et al.   Mucosal Immunology

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

(2010) Sofia Buonocore et al.   NATURE

Injection of glycosylated recombinant simian IL-7 provokes rapid and massive T-cell homing in rhesus macaques

(2009) S. Beq et al.   BLOOD

Differential regulation of interleukin 17 and interferon   production in inflammatory bowel disease

(2009) L. Rovedatti et al.   GUT

Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis

(2009) I. Arijs et al.   GUT

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mucosal Gene Expression of Antimicrobial Peptides in Inflammatory Bowel Disease Before and After First Infliximab Treatment

(2009) Ingrid Arijs et al.   PLoS One

Expression analysis and functional activity of interleukin-7 splice variants

(2008) N K Vudattu et al.   GENES AND IMMUNITY

Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor α-chain are excluded from the analysis

(2008) Laure Michel et al.   JOURNAL OF CLINICAL INVESTIGATION