Receptor occupancy and blocking of STAT5 signaling by an anti-IL-7 receptor α antibody in cynomolgus monkeys

Anti-IL21 receptor monoclonal antibody (ATR-107): Safety, pharmacokinetics, and pharmacodynamic evaluation in healthy volunteers: A phase I, first-in-human study

(2013) Fei Hua et al.   JOURNAL OF CLINICAL PHARMACOLOGY

pSTAT3: a target biomarker to study the pharmacology of the anti-IL-21R antibody ATR-107 in human whole blood

(2013) Ming Zhu et al.   Journal of Translational Medicine

Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis

(2011) George F Mells et al.   NATURE GENETICS

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

(2011) Carl A Anderson et al.   NATURE GENETICS

IL-7 Promotes TH1 Development and Serum IL-7 Predicts Clinical Response to Interferon-  in Multiple Sclerosis

(2011) L.-F. Lee et al.   Science Translational Medicine

The interleukin-7 receptor α chain contributes to altered homeostasis of regulatory T cells in multiple sclerosis

(2010) Jürgen Haas et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A CD8+ T cell transcription signature predicts prognosis in autoimmune disease

(2010) Eoin F McKinney et al.   NATURE MEDICINE

In Vitro and Clinical Investigation of the Relationship Between CCR5 Receptor Occupancy and Anti-HIV Activity of Aplaviroc

(2008) James F. Demarest et al.   JOURNAL OF CLINICAL PHARMACOLOGY