Safety Assessment of Compounds after In Vitro Metabolic Conversion Using Zebrafish Eleuthero Embryos

From mRNA Expression of Drug Disposition Genes to In Vivo Assessment of CYP-Mediated Biotransformation during Zebrafish Embryonic and Larval Development

(2018) Evy Verbueken et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cell Imaging Counting as a Novel Ex Vivo Approach for Investigating Drug-Induced Hepatotoxicity in Zebrafish Larvae

(2017) Xuan-Bac Nguyen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ZeGlobalTox: An Innovative Approach to Address Organ Drug Toxicity Using Zebrafish

(2017) Carles Cornet et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development of a sensitive and quantitative UHPLC-MS/MS method to study the whole-body uptake of pharmaceuticals in zebrafish

(2017) Stanislav Kislyuk et al.   TALANTA

Post-marketing withdrawal of 462 medicinal products because of adverse drug reactions: a systematic review of the world literature

(2016) Igho J. Onakpoya et al.   BMC Medicine

Phenotypic and biomarker evaluation of zebrafish larvae as an alternative model to predict mammalian hepatotoxicity

(2016) Sandra Verstraelen et al.   JOURNAL OF APPLIED TOXICOLOGY

Evaluation of the Toxicity and Antioxidant Activity of Redox Nanoparticles in Zebrafish (Danio rerio) Embryos

(2016) Long Binh Vong et al.   MOLECULAR PHARMACEUTICS

Advancements in zebrafish applications for 21st century toxicology

(2016) Gloria R. Garcia et al.   PHARMACOLOGY & THERAPEUTICS

Estrogenic Effects of Several BPA Analogs in the Developing Zebrafish Brain

(2016) Joel Cano-Nicolau et al.   Frontiers in Neuroscience

Use of Zebrafish Larvae as a Multi-Endpoint Platform to Characterize the Toxicity Profile of Silica Nanoparticles

(2016) Duc-Hung Pham et al.   Scientific Reports

Verapamil hepatic clearance in four preclinical rat models: towards activity-based scaling

(2015) J. Nicolaï et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates?

(2015) Natalie Mesens et al.   JOURNAL OF APPLIED TOXICOLOGY

Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling

(2013) Marja Driessen et al.   ARCHIVES OF TOXICOLOGY

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Comparisons betweenin vitrowhole cell imaging andin vivozebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development

(2012) Adrian Hill et al.   DRUG METABOLISM REVIEWS

Albendazole causes stage-dependent developmental toxicity and is deactivated by a mammalian metabolization system in a modified zebrafish embryotoxicity test

(2012) Anna Mattsson et al.   REPRODUCTIVE TOXICOLOGY

Zebrafish developmental toxicity assay: A fishy solution to reproductive toxicity screening, or just a red herring?

(2011) Kathleen Van den Bulck et al.   REPRODUCTIVE TOXICOLOGY

Feasibility study of the zebrafish assay as an alternative method to screen for developmental toxicity and embryotoxicity using a training set of 27 compounds

(2011) Ingrid W.T. Selderslaghs et al.   REPRODUCTIVE TOXICOLOGY

Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish

(2010) Jared V Goldstone et al.   BMC GENOMICS

Mechanisms of Drug Toxicity and Relevance to Pharmaceutical Development

(2010) F. Peter Guengerich   Drug Metabolism and Pharmacokinetics

Zebrafish teratogenicity test with metabolic activation (mDarT): Effects of phase I activation of acetaminophen on zebrafish Danio rerio embryos

(2010) Stefan Weigt et al.   TOXICOLOGY

Accumulation and metabolism of drugs and CYP probe substrates in zebrafish larvae

(2010) W. Alderton et al.   XENOBIOTICA

Regulatory aspects on the use of fish embryos in environmental toxicology

(2010) Marlies Halder et al.   Integrated Environmental Assessment and Management

Researchers Find Their Nemo

(2009) Anthony King   CELL

The use ofin vivozebrafish assays in drug toxicity screening

(2009) Peter M Eimon et al.   Expert Opinion on Drug Metabolism & Toxicology

Zebrafish: an emerging technology forin vivopharmacological assessment to identify potential safety liabilities in early drug discovery

(2008) T P Barros et al.   BRITISH JOURNAL OF PHARMACOLOGY

Development of a New Screening Assay to Identify Proteratogenic Substances using Zebrafish Danio rerio Embryo Combined with an Exogenous Mammalian Metabolic Activation System (mDarT)

(2008) François Busquet et al.   TOXICOLOGICAL SCIENCES