Paeonol alleviates CCl4-induced liver fibrosis through suppression of hepatic stellate cells activation via inhibiting the TGF-β/Smad3 signaling

Carvacrol ameliorates the progression of liver fibrosis through targeting of Hippo and TGF-β signaling pathways in carbon tetrachloride (CCl4)-induced liver fibrosis in rats

(2019) Roohollah Mohseni et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Bacterial Translocation Is Linked to Increased Intestinal IFN-γ, IL-4, IL-17, and mucin-2 in Cholestatic Rats

(2018) Natali Vega-Magaña et al.   Annals of Hepatology

Autocrine transforming growth factor-β/activin A-Smad signaling induces hepatic progenitor cells undergoing partial epithelial-mesenchymal transition states

(2018) Yu Wu et al.   BIOCHIMIE

Herbal compound 861 prevents hepatic fibrosis by inhibiting the TGF-β1/Smad/SnoN pathway in bile duct-ligated rats

(2018) Cheng Chi et al.   BMC Complementary and Alternative Medicine

Asiatic acid attenuates CCl 4 -induced liver fibrosis in rats by regulating the PI3K/AKT/mTOR and Bcl-2/Bax signaling pathways

(2018) Liwen Wei et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gypsophila elegans isoorientin-2″-O-α- l -arabinopyranosyl ameliorates porcine serum-induced immune liver fibrosis by inhibiting NF-κB signaling pathway and suppressing HSC activation

(2018) Facheng Bai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Wisteria floribunda agglutinin-positive Mac-2-binding protein and type 4 collagen 7S: useful markers for the diagnosis of significant fibrosis in patients with non-alcoholic fatty liver disease

(2018) Yuji Ogawa et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Liver fibrosis: Direct antifibrotic agents and targeted therapies

(2018) Detlef Schuppan et al.   MATRIX BIOLOGY

Contextual determinants of TGFβ action in development, immunity and cancer

(2018) Charles J. David et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Clinico-Pathological Importance of TGF-β/Phospho-Smad Signaling during Human Hepatic Fibrocarcinogenesis

(2018) Katsunori Yoshida et al.   Cancers

Endoplasmic reticulum stress-mediated autophagy activation attenuates fumonisin B1 induced hepatotoxicity in vitro and in vivo

(2017) Mahendra Pal Singh et al.   FOOD AND CHEMICAL TOXICOLOGY

Targeting CCl4 -induced liver fibrosis by RNA interference-mediated inhibition of cyclin E1 in mice

(2017) Jörg-Martin Bangen et al.   HEPATOLOGY

Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/ d -GalN-induced acute liver failure in mice

(2017) Xiaobao Gong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Intestinal flora imbalance promotes alcohol-induced liver fibrosis by the TGFβ/smad signaling pathway in mice

(2017) Dong Zhang et al.   Oncology Letters

Effects of exogenous thymosin β4 on carbon tetrachloride-induced liver injury and fibrosis

(2017) Xiankui Li et al.   Scientific Reports

Root bark of Ulmus davidiana var. japonica restrains acute alcohol-induced hepatic steatosis onset in mice by inhibiting ROS accumulation

(2017) Jeong Hoon Pan et al.   PLoS One

Loss of the transforming growth factor-β effector β2-Spectrin promotes genomic instability

(2016) Jian Chen et al.   HEPATOLOGY

Mechanisms of CCl4-induced liver fibrosis with combined transcriptomic and proteomic analysis

(2016) Shu Dong et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Enhanced antitumor activity and attenuated cardiotoxicity of Epirubicin combined with Paeonol against breast cancer

(2016) Jing Wu et al.   TUMOR BIOLOGY

Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets

(2016) Chong-Yang Zhang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Attenuating Oxidative Stress by Paeonol Protected against Acetaminophen-Induced Hepatotoxicity in Mice

(2016) Yi Ding et al.   PLoS One

Genetic and chemical characterization of white and red peony root derived from Paeonia lactiflora

(2014) Shu Zhu et al.   Journal of Natural Medicines

Paeonol inhibits hepatic fibrogenesis via disrupting nuclear factor-κB pathway in activated stellate cells: In vivo and in vitro studies

(2013) Desong Kong et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Human antigen R contributes to hepatic stellate cell activation and liver fibrosis

(2012) Ashwin Woodhoo et al.   HEPATOLOGY

Silencing tissue inhibitors of metalloproteinases (TIMPs) with short interfering RNA reveals a role for TIMP-1 in hepatic stellate cell proliferation

(2011) Andrew J. Fowell et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of mitochondrial respiration and apoptosis through cell signaling: Cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation

(2011) Maik Hüttemann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Paeonol, the main active principles of Paeonia moutan, ameliorates alcoholic steatohepatitis in mice

(2010) Shilian Hu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Inflammasome-mediated regulation of hepatic stellate cells

(2009) Azuma Watanabe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY