Review
Biochemistry & Molecular Biology
Tasuku Matsuoka, Masakazu Yashiro
Summary: TGF-beta plays a crucial role in the development, invasion, and metastasis of gastrointestinal cancers. Understanding the mechanisms and functions of TGF-beta signaling is important for diagnosis, prognosis, and the development of targeted therapies.
Article
Biochemistry & Molecular Biology
Tsugumasa Toma, Hiroshi Tateishi, Kensaku Kawakami, Taha F. S. Ali, Masahiro Kamo, Kazuaki Monde, Yuta Nakashima, Mikako Fujita, Masami Otsuka
Summary: Metastasis is the main cause of mortality in solid tumors, but there are no available antimetastatic drugs on the market. This study focused on a synthetic compound called HPH-15, which showed anti-EMT and anti-cell migration activities in non-small-cell lung cancer cells. HPH-15 was found to inhibit downstream TGF-beta signaling and could potentially lead to the development of new antimetastatic drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Matthew L. Hupy, Michelle G. Pedler, Biehuoy Shieh, Dongyan Wang, Xiao-Jing Wang, J. Mark Petrash
Summary: Cataract surgery can lead to a secondary lens abnormality known as posterior capsule opacification (PCO), which can increase treatment costs and reduce quality of life for patients. Studies suggest that inhibiting TGF-beta-mediated Smad signaling is a promising approach to prevent PCO pathogenesis following cataract surgery.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Oncology
Fatima Junaid, Goran Tomic, Richard Kemp, Doug J. Winton
Summary: Using human colon cancer DLD-1 cells, the study engineered a cell line with inducible Snail expression and found that partial EMT induced by Snail overexpression in DLD-1 cells leads to chemoresistance, increased tumor growth, and decreased apoptosis, highlighting the importance of bioavailable Snail in determining the phenotypic outcome.
Article
Biochemistry & Molecular Biology
Hwi Gon Kim, Ye Seon Lim, Seonyeong Hwang, Hye-Yoon Kim, Yuseok Moon, Yong Jung Song, Yong-Jin Na, Sik Yoon
Summary: DEHP, a commonly used plasticizer, may be linked to the development of endometriosis by inducing cell proliferation, migration, inflammation, and stemness through the TGF-β/Smad signaling pathway, providing novel insights into the pathogenesis of endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Li-Li Ren, Xiao-Jun Li, Ting-Ting Duan, Zheng-Hai Li, Jun-Zheng Yang, Ya-Mei Zhang, Liang Zou, Hua Miao, Ying-Yong Zhao
Summary: Fibrosis is the excessive deposition of extracellular matrix components in the processes of tissue repair, causing organ structural integrity and functional impairment. Transforming growth factor-beta (TGF-beta) is a key factor in promoting fibrosis by activating profibrotic signals. This review discusses the role of TGF-beta signaling in fibrotic organs, as well as potential therapeutic options for targeting tissue fibrosis through modulating TGF-beta signaling.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Min Mo, Yao Zeng, Yiqun Zeng, Shuting Li, Xiaoyang He, Xiaowen Chen, Qimei Luo, Mi Liu, Congwei Luo, Xianrui Dou, Fenfen Peng, Haibo Long
Summary: This study investigated the antifibrotic effects of NMPDOva in peritoneal fibrosis (PF) and its underlying mechanisms. NMPDOva treatment significantly alleviated PF and decreased extracellular matrix accumulation. Moreover, NMPDOva inhibited the TGF-beta 1/Smad and JAK/STAT signaling pathways to prevent PF.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Medicine, Research & Experimental
Rui Yu, Yan Wu, Ping He, Yu Bai, Yongzhe Zhang, Xiaohui Bian, Guangping Sun, Beiru Zhang
Summary: Renal fibrosis is the main pathology of chronic kidney disease and LMCD1 is upregulated in patients with CKD and treated kidney cells. Knockdown of LMCD1 can improve renal fibrosis by blocking the activation of the extracellular signal-regulated kinase pathway. The study further investigates the effect of LMCD1 on TGF-01-induced epithelial-mesenchymal transition (EMT) and its potential role in the TGF-01/Smad signaling pathway.
LABORATORY INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Guangwen Shu, Chenxi Dai, Arslan Yusuf, Hui Sun, Xukun Deng
Summary: Limonin inhibits TGF-beta-induced EMT of hepatocytes and activation of HSCs in vitro and alleviates mouse CCl4-induced liver fibrosis by upregulating Smad7.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Environmental Sciences
Yan Wang, Siling Li, Jing Zhao, Qiuyue Li, Chunjie Xu, Huihui Wu, Zhonghui Zhu, Lin Tian
Summary: The study revealed that partial EMT may be involved in the development of pulmonary fibrosis diseases, with Snail playing a critical role in the process. The process of EMT in epithelial cells promoted the differentiation of lung myofibroblasts, and this epithelial-mesenchymal crosstalk was mainly controlled by Snail.
Article
Chemistry, Medicinal
Dali Ding, Xuebin Shen, Lizhen Yu, Yueyue Zheng, Yao Liu, Wei Wang, Li Liu, Zitong Zhao, Sihui Nian, Limin Liu
Summary: Timosaponin BII (TS BII), a main constituent of Anemarrhena asphodeloides Bunge, was found to restore lung structure, inhibit collagen deposition, and reverse abnormal expression of EMT-related marker proteins in a bleomycin-induced pulmonary fibrosis (PF) model. Furthermore, TS BII suppressed EMT by inhibiting the TGF-beta/Smad pathway both in vivo and in vitro. Therefore, TS BII may be a promising candidate for PF treatment.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Wenwen Ding, Danhua Zhou, Shimeng Zhang, Jiaping Qian, Lingxia Yang, Lei Tang
Summary: This study demonstrates that Trimetazidine (TMZ) can inhibit liver fibrosis and hepatic stellate cell proliferation induced by CCl4 and TGF-beta. TMZ exerts its effects by blocking the activation of TGF beta/Smad signaling pathway. These findings provide new insights into the potential application of TMZ in the treatment of liver fibrosis.
Article
Oncology
Yu Xie, Shuai Zhu, Jinglei Zang, Guanlin Wu, Yuheng Wen, Yu Liang, Ying Long, Weiming Guo, Chuanbing Zang, Xiang Hu, Gang Fan, Shuanglin Xiang, Jian Zhang
Summary: ADNP is overexpressed in BC tissues of patients with tumor progression, and high ADNP expression is associated with shorter tumor-free survival in BC patients. Downregulation of ADNP increases sensitivity to cisplatin in BC, while overexpression of ADNP has the opposite effect. ADNP promotes cell migration and EMT, leading to cisplatin resistance, possibly through the TGF-β/Smad signaling pathway.
Article
Oncology
Ana Pavlic, Emanuela Bostjancic, Rajko Kavalar, Bojan Ilijevec, Serena Bonin, Fabrizio Zanconati, Nina Zidar
Summary: This study investigates the involvement of epithelial-mesenchymal transition (EMT) in tumor budding (TB) and poorly differentiated clusters (PDCs) in colorectal cancer (CRC). The results suggest that both TB and PDCs are associated with partial EMT, but they exhibit discrete differences in morphology and expression of EMT-related markers.
JOURNAL OF PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hui Zhang, Qiang Ruan, Changjiang Chen, Hui Yu, Shen Guan, Dan Hu, Chunkang Yang, Ruirong Lin, Changhua Zhuo
Summary: Colorectal cancer is a common malignancy with liver metastasis being the main cause of death. Radical resection is the most effective treatment, but not suitable for all patients. This study found that activin A/ACVR2A inhibits colon cancer cell migration and invasion, and suppresses the epithelial-to-mesenchymal transition. Activin A activates Smad2 and downregulation of ACVR2A is associated with colon cancer metastasis. Targeting ACVR2A is a potential novel therapeutic strategy for preventing colon cancer metastasis.
MOLECULAR CARCINOGENESIS
(2023)
Article
Chemistry, Multidisciplinary
Xin Liu, Ningbing Ye, Sha Liu, Jiankun Guan, Qingyuan Deng, Zhijie Zhang, Chen Xiao, Ze-yang Ding, Bi-xiang Zhang, Xiao-ping Chen, Zifu Li, Xiangliang Yang
Summary: This study utilized hyperbaric oxygen (HBO) to overcome mechanical and immunosuppressive limitations of T cell immune checkpoint inhibitors, such as PD-1 Ab, against solid tumors. HBO enhanced PD-1 Ab delivery and T cell infiltration, disrupting immunosuppression and promoting robust immune responses to inhibit tumor relapses. Such enhanced efficacy was observed in solid tumors in rodents and hepatocellular carcinoma patients, highlighting the potential of HBO-PD-1 Ab combination therapy in stroma-rich solid tumors.
Article
Oncology
Yao Chen, Jianping Zhao, Zhanguo Zhang, Zeyang Ding, Yifa Chen, Xiaoping Chen, Wanguang Zhang
Summary: This study developed a DVT risk prediction model (TRN) based on data from a large number of hepatocellular carcinoma patients who underwent laparoscopic hepatectomy, demonstrating good predictive value in both internal and external validation.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Article
Biochemistry & Molecular Biology
Junnan Liang, Ganxun Li, Jingyu Liao, Zhao Huang, Jingyuan Wen, Yu Wang, Zeyu Chen, Guangzhen Cai, Weiqi Xu, Zeyang Ding, Huifang Liang, Pran K. Datta, Liang Chu, Xiaoping Chen, Bixiang Zhang
Summary: This study reveals the role of SNORD17 in hepatocellular carcinoma (HCC) and its interaction with p53, suggesting it as a potential therapeutic target for HCC.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Biochemistry & Molecular Biology
Xiaochao Zhang, Yabing Hu, Yonglong Pan, Yixiao Xiong, Yuxin Zhang, Mengzhen Han, Keshuai Dong, Jia Song, Huifang Liang, Zeyang Ding, Xuewu Zhang, He Zhu, Qiumeng Liu, Xun Lu, Yongdong Feng, Xiaoping Chen, Zhanguo Zhang, Bixiang Zhang
Summary: DDR1 is upregulated in hepatocellular carcinoma (HCC) tissues and high expression of DDR1 is associated with poor prognosis. DDR1 promotes HCC metastasis through collagen-induced signaling.
Article
Oncology
Yonglong Pan, Mengzhen Han, Xiaochao Zhang, Yi He, Chaoyi Yuan, Yixiao Xiong, Xinxin Li, Chenglong Zeng, Kan Lu, He Zhu, Xun Lu, Qiumeng Liu, Huifang Liang, Zhibin Liao, Zeyang Ding, Zhanguo Zhang, Xiaoping Chen, Wanguang Zhang, Bixiang Zhang
Summary: The study reveals that DDR1 promotes liver cancer cell proliferation and tumor growth, while downregulation of DDR1 has the opposite effect. DDR1 interacts with SLC1A5 to regulate the mTORC1 signaling pathway. DDR1 serves as an independent prognostic marker, and its expression is positively correlated with SLC1A5 in clinical samples, providing new insights into HCC development and potential targets for treatment.
Review
Biotechnology & Applied Microbiology
Bin Yu, Xin Yu, Jianping Xiong, Mei Ma
Summary: Epigenetic regulation plays a crucial role in tumor metastasis, with DNA methylation, histone/RNA modification, and noncoding RNAs being key factors. The application of epigenetic therapies shows promise in cancer treatment, offering potential new avenues for diagnosis and prognosis of metastasis.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Oncology
Qian Yun Ge, Jin Chen, Gan Xun Li, Xiao Long Tan, Jia Song, Deng Ning, Jie Mo, Peng Cheng Du, Qiu Meng Liu, Hui Fang Liang, Ze Yang Ding, Xue Wu Zhang, Bi Xiang Zhang
Summary: GRAMD4 inhibits the migration and metastasis of HCC by promoting the degradation of TAK1, which leads to the inactivation of MAPK and NF-kappa B signalling pathways.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Guangzhen Cai, Jinghan Zhu, Deng Ning, Ganxun Li, Yuxin Zhang, Yixiao Xiong, Junnan Liang, Chengpeng Yu, Xiaoping Chen, Huifang Liang, Zeyang Ding
Summary: The role of hypoxia in hepatocellular carcinoma and its impact on the tumor microenvironment and drug sensitivity are not well understood. This study found that the Hypoxia_DEGs_Score model has excellent predictive value for survival. Hypoxia is closely related to somatic mutation, copy number variation, and DNA methylation, which affect tumor development, metastasis, and drug resistance. Aggravated hypoxic stress leads to immune exclusion phenotype and increased infiltration of immunosuppressive cells. Patients with high Hypoxia_DEGs_Score have worse immunotherapeutic outcomes and prognosis, and may benefit from drugs targeting cell cycle signaling pathways rather than those inhibiting the PI3K/mTOR pathway. Hypoxia_DEGs_Score can predict changes in the tumor microenvironment, the efficacy of immunotherapy, and drug response.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Yiyang Liu, Yufei Wang, Sheng Sun, Zeyu Chen, Shuai Xiang, Zeyang Ding, Zhao Huang, Bixiang Zhang
Summary: This article investigates the role of EpCAM in cancer and its communication with other signaling pathways. It introduces the impact on the biology of cancers and the latest clinical applications of EpCAM, aiming to shed light on its translational prospects.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Chen Xiao, Jiayuan Li, Xing Wang, Shiyou Li, Chen Xu, Zhijie Zhang, Ao Hua, Ze-yang Ding, Bi-xiang Zhang, Xiangliang Yang, Zifu Li
Summary: Cancer stem cells (CSCs) are responsible for tumor progression, treatment resistance, metastasis, and recurrence, but few drugs have successfully eliminated CSCs by increasing oxidative stress. In this study, we introduced hydroxyethyl starch stabilized copper-diethyldithiocarbamate nanoparticles (CuET@HES NPs) that effectively suppressed CSCs in vitro and in various in vivo tumor models. The CuET@HES NPs also showed great efficacy in inhibiting CSCs in fresh tumor tissues from hepatocellular carcinoma patients. This research has significant implications for the development of CSC-targeting nanomedicines.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Urology & Nephrology
Chaoyi Yuan, Guannan Jin, Pengcheng Li, Wei Wang, Chang Ge, Yonglong Pan, Qiaofeng Zhang, Jie Mo, Dong Kuang, Liu Liu, Xuewu Zhang, Huifang Liang, Wanguang Zhang, Xi Tang, Zifu Li, Jihong Liu, Gang Xu, Xiaoping Chen, Ze-yang Ding, Bixiang Zhang
Summary: Tubulointerstitial fibrosis is the final path of progressive chronic kidney diseases regardless of the cause. The transcriptional intermediary factor 1y (TIF1y) has been found to be highly expressed in the kidney tubules and inhibits the progression of fibrosis. Loss of TIF1y exacerbates tubular cell polyploidy and fibrosis, while overexpression protects against kidney fibrosis. TIF1y exerts its antifibrotic role by inhibiting TGF-D and EGFR signaling pathways.
KIDNEY INTERNATIONAL
(2023)
Review
Cell Biology
Kan Lu, Yonglong Pan, Zhao Huang, Huifang Liang, Ze-Yang Ding, Bixiang Zhang
Summary: The TRIM protein family is a versatile and highly conserved group of proteins that function as E3 ligases, regulating the development of hepatocellular carcinoma.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Cell Biology
Yan-Hui Wu, Bin Yu, Wei-Xun Chen, Xi Ai, Wei Zhang, Wei Dong, Ya-Jie Shao
Summary: The study demonstrates that the downregulation of lncRNA SBF2-AS1 inhibits proliferation and migration of HCC cells by regulating the miR-361-5p/TGF-beta 1 signaling pathway.
Review
Medicine, Research & Experimental
Jitang Chen, Ze-yang Ding, Si Li, Sha Liu, Chen Xiao, Zifu Li, Bi-xiang Zhang, Xiao-ping Chen, Xiangliang Yang
Summary: Targeting TGF beta signaling for cancer therapy presents challenges and opportunities, as inhibitors can enhance chemotherapy efficacy but must also consider the dual role of TGF beta in normal tissues and tumors to avoid unwanted side effects.
Article
Medicine, Research & Experimental
Jia Song, Yachong Liu, Furong Liu, Lu Zhang, Ganxun Li, Chaoyi Yuan, Chengpeng Yu, Xun Lu, Qiumeng Liu, Xiaoping Chen, Huifang Liang, Zeyang Ding, Bixiang Zhang
Summary: The 14-3-3 sigma protein plays a pivotal role in anoikis resistance and metastasis of hepatocellular carcinoma cells by inhibiting EGFR degradation and regulating the activation of the EGFR-dependent ERK1/2 pathway. This study offers new research directions for targeting 14-3-3 sigma in the treatment of metastatic cancer.
Article
Biochemistry & Molecular Biology
Siva Santhiya Arul, Brinda Balakrishnan, Savithri S. Handanahal, Sangita Venkataraman
Summary: Viral nanoparticles are self-assembling delivery systems used for vaccines and therapeutic agents. They have improved biocompatibility and are widely used in various biomedical applications. However, large-scale production of VNPs still faces challenges.
Article
Biochemistry & Molecular Biology
Wisely Chua, Carl O. Marsh, Si En Poh, Winston LC. Koh, Melody Li Ying Lee, Li Fang Koh, Xin-Zi Emily Tang, Peter See, Zheng Ser, Shi Mei Wang, Radoslaw M. Sobota, Thomas L. Dawson Jr, Yik Weng Yew, Steven Thng, Anthony J. O'Donoghue, Hazel H. Oon, John E. Common, Hao Li
Summary: In this study, the gene expression of enzymes secreted by Malassezia globosa in the skin was investigated using targeted RNA sequencing. The study found that the expression of these enzymes is regulated by the fungus's environment and differs significantly from healthy skin sites. Additionally, a pseudoprotease MGL_3331 was identified to elicit an immune reaction in patients with atopic dermatitis. This highlights the importance of studying fungal proteins in physiologically relevant environments and their role in host immunity.
Article
Biochemistry & Molecular Biology
Belisa Parmeggiani, Marian Flores Signori, Cristiane Cecatto, Marina Rocha Frusciante, Manuela Bianchin Marcuzzo, Debora Guerini Souza, Rafael Teixeira Ribeiro, Bianca Seminotti, Diogo Onofre Gomes de Souza, Cesar Augusto Joa o Ribeiro, Moacir Wajner, Guilhian Leipnitz
Summary: Non ketotic hyperglycinemia (NKH) is a disorder caused by mutations in the genes encoding glycine cleavage system proteins, leading to severe neurodegeneration and white matter alterations. The study found that glycine affects myelin structure, glutamatergic system, and induces oxidative stress in neonatal rats and MO3.13 oligodendroglial cells.
Review
Biochemistry & Molecular Biology
Marie Rose Ndella Thiaw, Pascal Gantet
Summary: Mini zinc fingers play important roles in plant development, including control of cell division and expansion, meristem state transition, and growth and organ development. They have diverse modes of action, such as direct gene activation, interaction with specific transcription factors, and aggregation of protein complexes for chromatin remodeling. Further research is needed to explore their wider range of biological functions and their involvement in biotic and abiotic stress responses.
Article
Biochemistry & Molecular Biology
Shao-Jui Lai, Takahiro Kameda, Maasa Morita, Yuka Yamagata, Kaoruko Nishizaka, Yuna Horiuchi, Yukihiro Kobayashi, Yoko Usami, Jun-Jen Liu, Takeshi Kasama, Minoru Tozuka, Ryunosuke Ohkawa
Summary: In this study, the co-modification and impact of chymase and MPO on HDL were investigated. Sequential treatment with MPO and chymase generated two novel apoA-I fragments from HDL, one of which has a specific immunological property and can be used to predict patients with normal HDL-C levels and cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Xiao-Mi Sun, Asami Yoshida, Takuya Ishii, Yan-Rong Jiang, Yi-Li Gao, Mikinori Ueno, Katsuya Hirasaka, Kiyoshi Osatomi
Summary: This study found that infection with the causative bacteria of edwardsiellosis, Edwardsiella tarda NUF251, leads to the production of superoxide radicals, causing oxidative stress. The research on the Jfsod1 gene suggests that the transcription factor NF-IL6 plays a significant role in upregulating the transcriptional activity of the gene in response to oxidative stress induced by NUF251 infection.
Article
Biochemistry & Molecular Biology
Shane M. Carey, Sean P. Kearns, Matthew E. Millington, Gregory S. Buechner, Beda E. Alvarez Jr, Leily Daneshian, Brendan Abiskaroon, Maksymilian Chruszcz, Edward L. D'Antonio
Summary: The importance of F337 in TcGlcK was investigated using the hole mutagenesis approach, revealing its key interactions with aromatic tail groups in inhibitor molecules. Mutants retaining activity and structural similarity were obtained, suggesting the possibility of TcHxK existing as a monomer lacking the F337 residue. Similar D-glucosamine inhibitors may bind less strongly to TcHxK due to the absence of van der Waals contacts from residue side chains.
Article
Biochemistry & Molecular Biology
Catia Barria, Diogo Athayde, Guillem Hernandez, Leonor Fonseca, Jorge Casinhas, Tiago N. Cordeiro, Margarida Archer, Cecilia M. Arraiano, Jose A. Brito, Rute G. Matos
Summary: Ribonucleases play a crucial role in RNA regulation by processing, degrading, and quality controlling cellular transcripts. Campylobacter jejuni, the main cause of human gastroenteritis, relies on the exoribonuclease PNPase (CjPNP) for low-temperature survival, virulence factor synthesis, and swimming, cell adhesion/invasion, and chick colonization abilities. The crystallographic structure of CjPNP, along with SAXS analysis, confirms its trimeric arrangement and provides insight into domain arrangement and flexibility. Mutations in highly conserved residues reveal unexpected RNA degradation activity even under conditions favoring polymerization. These findings have significant implications for the development of strategies to combat C. jejuni infections.
Article
Biochemistry & Molecular Biology
Elvira R. Shaykhutdinova, Maria S. Severyukhina, Inna V. Kholoshenko, Elena A. Gondarenko, Irina V. Shelukhina, Elena V. Kryukova, Alina M. Ismailova, Elena S. Sadovnikova, Igor A. Dyachenko, Arkady N. Murashev, Victor I. Tsetlin, Yuri N. Utkin
Summary: Evidence suggests that activating nicotinic acetylcholine receptors (nAChRs) can reduce cardiac injury caused by ischemia and reperfusion. In this study, the expression of a4, a6, and a132 nAChR subunits in the rat heart's left ventricle was demonstrated. The nAChR agonists cytisine and varenicline, commonly used for nicotine addiction treatment, were found to significantly reduce myocardial ischemia-reperfusion injury, with varenicline showing greater protection. The presence of a4132, a7, and/or a6132-containing receptors suggests that the protective effect of varenicline may be mediated by these subunits. These findings indicate a potential new use for cytisine and varenicline as cardioprotective agents.
Article
Biochemistry & Molecular Biology
Xinhai Xiong, Wenjie Chen, Cheng Chen, Qi Wu, Chaopeng He
Summary: This article summarizes the important roles of Cx43 in disease development from the perspective of subcellular localization and provides new ideas for Cx43 as a therapeutic target and the search for related pathological mechanisms.
Article
Biochemistry & Molecular Biology
Veronica Bastos, Simone Pascoal, Kamila Lopes, Marcia Mortari, Helena Oliveira
Summary: Cancer, especially melanoma, is a major global health problem due to its metastatic capacity, treatment resistance, and high mortality rates. The Chartergellus-CP1 peptide isolated from Chartergellus communis wasp venom showed selective cytotoxicity towards melanoma cell lines, inducing apoptosis, cell cycle impairment, and intracellular ROS increase.
Article
Biochemistry & Molecular Biology
Charlotte Claeyssen, Nathan Bulangalire, Bruno Bastide, Onnik Agbulut, Caroline Cieniewski-Bernard
Summary: Maintenance of striated muscle tissue relies on a dynamic network of protein-protein interactions. Desmin intermediate filaments play a crucial role in heart and skeletal muscle by maintaining cell structure and contributing to various cellular processes. The assembly of desmin intermediate filaments requires aB-crystallin, which is involved in multiple cellular functions.
Article
Biochemistry & Molecular Biology
Dhritiman Dey, Adhiraj Dasgupta, Dipanjan Ghosh, Oindrila Bhattacharjee, Abhrajyoti Ghosh, Ayae Honda, Dhrubajyoti Chattopadhyay
Summary: This study successfully identified host factors that interact with Chandipura Virus (CHPV) and play a critical role in infection, including A2M, LRP1, and GRP78. Knocking out A2M has a severe effect on viral infection, indicating the potential role of these host proteins in viral entry into host cells.
Article
Biochemistry & Molecular Biology
Anna Dotsenko, Igor Sinelnikov, Aleksandra Rozhkova, Ivan Zorov, Arkady Sinitsyn
Summary: Xylanases play important roles in various industrial applications, such as feed additives, pulp and paper bleaching, and the production of bread, food, and drinks. Xylanases from the GH10 family show high thermostability and resistance to protein inhibitors, making them promising candidates for these processes. This study successfully improved the thermostability and enzymatic activity of GH10 xylanase, which could enhance its effectiveness as a feed additive and during pulp and paper bleaching.
Article
Biochemistry & Molecular Biology
M. Jaquet, M. Bengue, K. Lambert, G. Carnac, D. Misse, C. Bisbal
Summary: Changes to our environment have led to the emergence of human pathogens such as chikungunya virus, which is now a major public health concern. In this study, the interconnection between skeletal muscle cells metabolism, their differentiation stage, and the infectivity of chikungunya virus was investigated. The results showed that chikungunya virus infectivity is dependent on cell differentiation and metabolism and that the virus interferes with cellular metabolism.
