Regulators of T‐cell fate: Integration of cell migration, differentiation and function

TIM-3 Regulates CD103 + Dendritic Cell Function and Response to Chemotherapy in Breast Cancer

(2018) Álvaro de Mingo Pulido et al.   CANCER CELL

Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells

(2018) Mauro Gaya et al.   CELL

IFN-γ-induced chemokines are required for CXCR3-mediated T cell recruitment and anti-tumor efficacy of anti-HER2/CD3 bispecific antibody

(2018) Ji Li et al.   CLINICAL CANCER RESEARCH

T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells

(2018) Lalit K. Beura et al.   IMMUNITY

Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity

(2018) Lauren B. Rodda et al.   IMMUNITY

Stromal cell networks coordinate immune response generation and maintenance

(2018) Yannick O. Alexandre et al.   IMMUNOLOGICAL REVIEWS

Plasmacytoid dendritic cell heterogeneity is defined by CXCL10 expression following TLR7 stimulation

(2018) Casper Marsman et al.   IMMUNOLOGY AND CELL BIOLOGY

Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy

(2018) Bijun Zeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Altered immune cell follicular dynamics in HIV infection following influenza vaccination

(2018) Eirini Moysi et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterization of a chimeric chemokine as a specific ligand for ACKR3

(2018) Rafet Ameti et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Circulating T FH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

(2018) Marios Koutsakos et al.   Science Translational Medicine

PD-1 Controls Follicular T Helper Cell Positioning and Function

(2018) Jingwen Shi et al.   IMMUNITY

The Chemokine Receptor CCR8 Promotes the Migration of Dendritic Cells into the Lymph Node Parenchyma to Initiate the Allergic Immune Response

(2018) Caroline L. Sokol et al.   IMMUNITY

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells

(2018) Daniel DiToro et al.   SCIENCE

Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes

(2018) Imogen Moran et al.   Nature Communications

The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation

(2018) Konstantin Knoblich et al.   PLOS BIOLOGY

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

(2018) Christopher S. Garris et al.   IMMUNITY

SLAMF7 Is a Critical Negative Regulator of IFN-α–Mediated CXCL10 Production in Chronic HIV Infection

(2018) Patrick O’Connell et al.   JOURNAL OF IMMUNOLOGY

Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin

(2018) Simone L. Park et al.   NATURE

Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation

(2018) Jeffrey S. Smith et al.   Science Signaling

CD8 + T Cells Orchestrate pDC-XCR1 + Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming

(2017) Anna Brewitz et al.   IMMUNITY

Lymph node targeting strategies to improve vaccination efficacy

(2017) Hao Jiang et al.   JOURNAL OF CONTROLLED RELEASE

Dendritic cell and antigen dispersal landscapes regulate T cell immunity

(2017) Michael Y. Gerner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STAT4 and T-bet control follicular helper T cell development in viral infections

(2017) Jason S. Weinstein et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chemokine Receptor–Dependent Control of Skin Tissue–Resident Memory T Cell Formation

(2017) Ali Zaid et al.   JOURNAL OF IMMUNOLOGY

Nasal-associated lymphoid tissues (NALTs) support the recall but not priming of influenza virus-specific cytotoxic T cells

(2017) Angela Pizzolla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2

(2017) Zil E. Huma et al.   Science Signaling

An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment

(2017) Leena Halim et al.   Cell Reports

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2

(2017) Zil E. Huma et al.   Science Signaling

T Follicular Helper Cell Plasticity Shapes Pathogenic T Helper 2 Cell-Mediated Immunity to Inhaled House Dust Mite

(2016) André Ballesteros-Tato et al.   IMMUNITY

The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis

(2016) Carmen Gerlach et al.   IMMUNITY

pMHC affinity controls duration of CD8 + T cell–DC interactions and imprints timing of effector differentiation versus expansion

(2016) Aleksandra J. Ozga et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+T cells into distinct effector subsets

(2016) Cindy S. Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Singular role for T-BET+CXCR3+regulatory T cells in protection from autoimmune diabetes

(2016) Tze Guan Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions

(2015) Sarah Eickhoff et al.   CELL

Spatiotemporally Distinct Interactions with Dendritic Cell Subsets Facilitates CD4+ and CD8+ T Cell Activation to Localized Viral Infection

(2015) Jyh Liang Hor et al.   IMMUNITY

CXCR3 Chemokine Receptor Enables Local CD8+ T Cell Migration for the Destruction of Virus-Infected Cells

(2015) Heather D. Hickman et al.   IMMUNITY

T Follicular Helper Cells Have Distinct Modes of Migration and Molecular Signatures in Naive and Memory Immune Responses

(2015) Dan Suan et al.   IMMUNITY

Strategically Localized Dendritic Cells Promote Rapid T Cell Responses to Lymph-Borne Particulate Antigens

(2015) Michael Y. Gerner et al.   IMMUNITY

Moving to the suburbs: T-cell positioning within lymph nodes during activation and memory

(2015) Joanna R Groom   IMMUNOLOGY AND CELL BIOLOGY

The importance of co-stimulation in the orchestration of T helper cell differentiation

(2015) Jonathan M Coquet et al.   IMMUNOLOGY AND CELL BIOLOGY

Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies

(2015) Cindy S. Ma et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Nanoparticulate STING agonists are potent lymph node–targeted vaccine adjuvants

(2015) Melissa C. Hanson et al.   JOURNAL OF CLINICAL INVESTIGATION

XCR1+dendritic cells promote memory CD8+T cell recall upon secondary infections withListeria monocytogenesor certain viruses

(2015) Yannick O. Alexandre et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T Follicular Helper, but Not Th1, Cell Differentiation in the Absence of Conventional Dendritic Cells

(2015) Madelene W. Dahlgren et al.   JOURNAL OF IMMUNOLOGY

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

(2015) Dongjun Peng et al.   NATURE

A KALA-modified lipid nanoparticle containing CpG-free plasmid DNA as a potential DNA vaccine carrier for antigen presentation and as an immune-stimulative adjuvant

(2015) Naoya Miura et al.   NUCLEIC ACIDS RESEARCH

Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints

(2015) M. E. Mikucki et al.   Nature Communications

IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival

(2015) Serena Lunardi et al.   Oncotarget

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Trans-nodal migration of resident dendritic cells into medullary interfollicular regions initiates immunity to influenza vaccine

(2014) Matthew C. Woodruff et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T-bet and Eomesodermin Play Critical Roles in Directing T Cell Differentiation to Th1 versus Th17

(2014) Y. Yang et al.   JOURNAL OF IMMUNOLOGY

Structure-based programming of lymph-node targeting in molecular vaccines

(2014) Haipeng Liu et al.   NATURE

The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes

(2014) Maria H Ulvmar et al.   NATURE IMMUNOLOGY

The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells

(2014) Makoto Kurachi et al.   NATURE IMMUNOLOGY

Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes

(2014) L. Jeanbart et al.   Cancer Immunology Research

Persistent Antigen and Germinal Center B Cells Sustain T Follicular Helper Cell Responses and Phenotype

(2013) Dirk Baumjohann et al.   IMMUNITY

Peripheral Prepositioning and Local CXCL9 Chemokine-Mediated Guidance Orchestrate Rapid Memory CD8+ T Cell Responses in the Lymph Node

(2013) Wolfgang Kastenmüller et al.   IMMUNITY

Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

(2013) Michela Locci et al.   IMMUNITY

Pathobiology of HIV/SIV-associated changes in secondary lymphoid tissues

(2013) Jacob D. Estes   IMMUNOLOGICAL REVIEWS

CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

(2013) Kate S. Smigiel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD8+ T Cells Produce the Chemokine CXCL10 in Response to CD27/CD70 Costimulation To Promote Generation of the CD8+ Effector T Cell Pool

(2013) V. Peperzak et al.   JOURNAL OF IMMUNOLOGY

Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility

(2013) Heping Xu et al.   NATURE

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling

(2013) J. R. Teijaro et al.   SCIENCE

Accelerating Next-Generation Vaccine Development for Global Disease Prevention

(2013) W. C. Koff et al.   SCIENCE

Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination

(2013) S.-E. Bentebibel et al.   Science Translational Medicine

Viral vaccines: past successes and future challenges

(2013) Rafi Ahmed et al.   Current Opinion in Virology

Identification and profiling of CXCR3-CXCR4 chemokine receptor heteromer complexes

(2012) AO Watts et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chemokine Guidance of Central Memory T Cells Is Critical for Antiviral Recall Responses in Lymph Nodes

(2012) Jung Hwan Sung et al.   CELL

A Spatially-Organized Multicellular Innate Immune Response in Lymph Nodes Limits Systemic Pathogen Spread

(2012) Wolfgang Kastenmüller et al.   CELL

CXCR3 Chemokine Receptor-Ligand Interactions in the Lymph Node Optimize CD4+ T Helper 1 Cell Differentiation

(2012) Joanna R. Groom et al.   IMMUNITY

The Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses

(2012) Jinfang Zhu et al.   IMMUNITY

T-bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2

(2012) Meghan A. Koch et al.   IMMUNITY

The development and fate of follicular helper T cells defined by an IL-21 reporter mouse

(2012) Katja Lüthje et al.   NATURE IMMUNOLOGY

Regulation of TH2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells

(2012) Beatriz León et al.   NATURE IMMUNOLOGY

Subcapsular Sinus Macrophage Fragmentation and CD169+ Bleb Acquisition by Closely Associated IL-17-Committed Innate-Like Lymphocytes

(2012) Elizabeth E. Gray et al.   PLoS One

Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection

(2012) M. A. Paley et al.   SCIENCE

Type-I IFN drives the differentiation of short-lived effector CD8+T cells in vivo

(2011) Melanie Wiesel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CXCR3 in T cell function

(2011) Joanna R. Groom et al.   EXPERIMENTAL CELL RESEARCH

Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion

(2011) Rimpei Morita et al.   IMMUNITY

Early Th1 Cell Differentiation Is Marked by a Tfh Cell-like Transition

(2011) Shingo Nakayamada et al.   IMMUNITY

Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4+ Cell Properties during Viral Infection

(2011) Heather D. Marshall et al.   IMMUNITY

Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone

(2011) Steven M. Kerfoot et al.   IMMUNITY

Functional and Epigenetic Studies Reveal Multistep Differentiation and Plasticity of In Vitro-Generated and In Vivo-Derived Follicular T Helper Cells

(2011) Kristina T. Lu et al.   IMMUNITY

CXCR3 ligands: redundant, collaborative and antagonistic functions

(2011) Joanna R Groom et al.   IMMUNOLOGY AND CELL BIOLOGY

Chemokines control naive CD8+T cell selection of optimal lymph node antigen presenting cells

(2011) Heather D. Hickman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammatory chemokine receptors regulate CD8+T cell contraction and memory generation following infection

(2011) Jacob E. Kohlmeier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chemokine receptor CXCR3 facilitates CD8+T cell differentiation into short-lived effector cells leading to memory degeneration

(2011) Makoto Kurachi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Duration of Antigen Availability Influences the Expansion and Memory Differentiation of T Cells

(2011) D. A. Blair et al.   JOURNAL OF IMMUNOLOGY

Afferent lymph–derived T cells and DCs use different chemokine receptor CCR7–dependent routes for entry into the lymph node and intranodal migration

(2011) Asolina Braun et al.   NATURE IMMUNOLOGY

Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection

(2011) Charlly Kao et al.   NATURE IMMUNOLOGY

Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation

(2011) J. K. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Immobilized Chemokine Fields and Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic Cells

(2010) Kathrin Schumann et al.   IMMUNITY

Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus

(2010) Matteo Iannacone et al.   NATURE

CD169+ macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes

(2010) Patricia Barral et al.   NATURE IMMUNOLOGY

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

(2010) J. J. O'Shea et al.   SCIENCE

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

(2009) Meghan A Koch et al.   NATURE IMMUNOLOGY

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

Control of Chemokine-Guided Cell Migration by Ligand Sequestration

(2008) Bijan Boldajipour et al.   CELL

Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes

(2008) Heather D Hickman et al.   NATURE IMMUNOLOGY

Fluorescence Resonance Energy Transfer Imaging Reveals that Chemokine-Binding Modulates Heterodimers of CXCR4 and CCR5 Receptors

(2008) Nilgun Isik et al.   PLoS One