Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+T cells into distinct effector subsets

Persistent nodal histoplasmosis in nuclear factor kappa B essential modulator deficiency: Report of a case and review of infection in primary immunodeficiencies

(2016) Jana P. Lovell et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Combined immunodeficiency with CD4 lymphopenia and sclerosing cholangitis caused by a novel loss-of-function mutation affecting IL21R

(2015) B. Erman et al.   HAEMATOLOGICA

T Follicular Helper Cells Have Distinct Modes of Migration and Molecular Signatures in Naive and Memory Immune Responses

(2015) Dan Suan et al.   IMMUNITY

Inherited and acquired immunodeficiencies underlying tuberculosis in childhood

(2015) Stéphanie Boisson-Dupuis et al.   IMMUNOLOGICAL REVIEWS

Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies

(2015) Cindy S. Ma et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

(2015) Alexandra Y. Kreins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An Inhibitory Role for the Transcription Factor Stat3 in Controlling IL-4 and Bcl6 Expression in Follicular Helper T Cells

(2015) Hao Wu et al.   JOURNAL OF IMMUNOLOGY

Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

(2015) S. Okada et al.   SCIENCE

The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa

(2015) Heather D Marshall et al.   eLife

Combined immunodeficiency with CD4 lymphopenia and sclerosing cholangitis caused by a novel loss-of-function mutation affecting IL21R

(2015) B. Erman et al.   HAEMATOLOGICA

Human IL-21 and IL-21R deficiencies

(2014) Daniel Kotlarz et al.   CURRENT OPINION IN PEDIATRICS

Extending the clinical and immunological phenotype of human interleukin-21 receptor deficiency

(2014) P. Stepensky et al.   HAEMATOLOGICA

Early-onset inflammatory bowel disease and common variable immunodeficiency–like disease caused by IL-21 deficiency

(2014) Elisabeth Salzer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

First Report of the Hyper-IgM Syndrome Registry of the Latin American Society for Immunodeficiencies: Novel Mutations, Unique Infections, and Outcomes

(2014) Otavio Cabral-Marques et al.   JOURNAL OF CLINICAL IMMUNOLOGY

TGF-β prevents T follicular helper cell accumulation and B cell autoreactivity

(2014) Mark J. McCarron et al.   JOURNAL OF CLINICAL INVESTIGATION

Autocrine Regulation of IL-21 Production in Human T Lymphocytes

(2014) F. Caprioli et al.   JOURNAL OF IMMUNOLOGY

Circulating CXCR5+PD-1+Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults

(2014) Ramin Sedaghat Herati et al.   JOURNAL OF IMMUNOLOGY

The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells

(2014) Nathalie Schmitt et al.   NATURE IMMUNOLOGY

Functional heterogeneity of human memory CD4+ T cell clones primed by pathogens or vaccines

(2014) S. Becattini et al.   SCIENCE

Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage

(2014) Leen Moens et al.   Frontiers in Immunology

IL-12 receptor  1 deficiency alters in vivo T follicular helper cell response in humans

(2013) N. Schmitt et al.   BLOOD

Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure

(2013) Jing He et al.   IMMUNITY

Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

(2013) Michela Locci et al.   IMMUNITY

Helper T-cell identity and evolution of differential transcriptomes and epigenomes

(2013) Golnaz Vahedi et al.   IMMUNOLOGICAL REVIEWS

Transcriptional regulation of follicular T-helper (Tfh) cells

(2013) Xindong Liu et al.   IMMUNOLOGICAL REVIEWS

Mechanisms underlying helper T-cell plasticity: Implications for immune-mediated disease

(2013) Kiyoshi Hirahara et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome

(2013) Daniel Kotlarz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells

(2013) Elissa K. Deenick et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inherited IL-12p40 Deficiency

(2013) Carolina Prando et al.   MEDICINE

IL-10 and IL-10 receptor defects in humans

(2012) Erik-Oliver Glocker et al.   Annals of the New York Academy of Sciences

Impaired peripheral blood T-follicular helper cell function in HIV-infected nonresponders to the 2009 H1N1/09 vaccine

(2012) S. Pallikkuth et al.   BLOOD

Functional STAT3 deficiency compromises the generation of human T follicular helper cells

(2012) C. S. Ma et al.   BLOOD

Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis

(2012) Anne Puel et al.   Current Opinion in Allergy and Clinical Immunology

Bcl6 expression specifies the T follicular helper cell program in vivo

(2012) Xindong Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Importance of B cell co-stimulation in CD4+ T cell differentiation: X-linked agammaglobulinaemia, a human model

(2011) H. Martini et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Infectious Diseases in Patients with IRAK-4, MyD88, NEMO, or I B  Deficiency

(2011) C. Picard et al.   CLINICAL MICROBIOLOGY REVIEWS

Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion

(2011) Rimpei Morita et al.   IMMUNITY

Early Th1 Cell Differentiation Is Marked by a Tfh Cell-like Transition

(2011) Shingo Nakayamada et al.   IMMUNITY

Dissecting the human immunologic memory for pathogens

(2011) Christina E. Zielinski et al.   IMMUNOLOGICAL REVIEWS

Dendritic cells from X-linked hyper-IgM patients present impaired responses to Candida albicans and Paracoccidioides brasiliensis

(2011) Otavio Cabral Marques et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expanding the Clinical and Genetic Spectrum of Human CD40L Deficiency: The Occurrence of Paracoccidioidomycosis and Other Unusual Infections in Brazilian Patients

(2011) Otavio Cabral-Marques et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Gain-of-function humanSTAT1mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis

(2011) Luyan Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity

(2011) A. Puel et al.   SCIENCE

The genetic network controlling plasma cell differentiation

(2011) Stephen L. Nutt et al.   SEMINARS IN IMMUNOLOGY

Regulation of T follicular helper cell formation and function by antigen presenting cells

(2010) Elissa K Deenick et al.   CURRENT OPINION IN IMMUNOLOGY

Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors

(2010) Jinfang Zhu et al.   IMMUNOLOGICAL REVIEWS

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

(2010) Marcel Batten et al.   JOURNAL OF EXPERIMENTAL MEDICINE

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

(2010) Danielle T. Avery et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Revisiting Human IL-12Rβ1 Deficiency

(2010) Ludovic de Beaucoudrey et al.   MEDICINE

Proinflammatory T helper type 17 cells are effective B-cell helpers

(2010) M. Mitsdoerffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

(2010) J. J. O'Shea et al.   SCIENCE

Human Dendritic Cells Induce the Differentiation of Interleukin-21-Producing T Follicular Helper-like Cells through Interleukin-12

(2009) Nathalie Schmitt et al.   IMMUNITY

Early commitment of naïve human CD4+ T cells to the T follicular helper (TFH ) cell lineage is induced by IL-12

(2009) Cindy S Ma et al.   IMMUNOLOGY AND CELL BIOLOGY

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

(2009) Katia Boniface et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-21 Mediates Suppressive Effects via Its Induction of IL-10

(2009) R. Spolski et al.   JOURNAL OF IMMUNOLOGY

Hypomorphic nuclear factor-κB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity

(2008) Eric P. Hanson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Development and characterization of IL-21–producing CD4+T cells

(2008) Akira Suto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deficiency of Th17 cells in hyper IgE syndrome due to mutations inSTAT3

(2008) Cindy S. Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutations inSTAT3andIL12RB1impair the development of human IL-17–producing T cells

(2008) Ludovic de Beaucoudrey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

(2008) Joshua D. Milner et al.   NATURE