Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?
Authors
Keywords
-
Journal
HUMAN GENETICS
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-04-27
DOI
10.1007/s00439-019-02014-8
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Prenatal alcohol exposure and facial morphology in a UK cohort
- (2019) Laurence J. Howe et al. DRUG AND ALCOHOL DEPENDENCE
- Why structure matters
- (2019) Nick Barton et al. eLife
- Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies
- (2019) Mashaal Sohail et al. eLife
- Reduced signal for polygenic adaptation of height in UK Biobank
- (2019) Jeremy J Berg et al. eLife
- Effect of genetic architecture on the prediction accuracy of quantitative traits in samples of unrelated individuals
- (2018) Fabio Morgante et al. HEREDITY
- The nature of nurture: Effects of parental genotypes
- (2018) Augustine Kong et al. SCIENCE
- Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
- (2018) Neil M Davies et al. BMJ-British Medical Journal
- A population genetic interpretation of GWAS findings for human quantitative traits
- (2018) Yuval B. Simons et al. PLOS BIOLOGY
- Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
- (2018) Neil M Davies et al. BMJ-British Medical Journal
- Relatedness disequilibrium regression estimates heritability without environmental bias
- (2018) Alexander I. Young et al. NATURE GENETICS
- Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations
- (2018) Amit V. Khera et al. NATURE GENETICS
- A tutorial on how not to over-interpret STRUCTURE and ADMIXTURE bar plots
- (2018) Daniel J. Lawson et al. Nature Communications
- SumHer better estimates the SNP heritability of complex traits from summary statistics
- (2018) Doug Speed et al. NATURE GENETICS
- Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution
- (2017) Reedik Mägi et al. HUMAN MOLECULAR GENETICS
- Genetic architecture: the shape of the genetic contribution to human traits and disease
- (2017) Nicholas J. Timpson et al. NATURE REVIEWS GENETICS
- Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia
- (2016) Kevin J. Galinsky et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Transethnic Genetic-Correlation Estimates from Summary Statistics
- (2016) Brielin C. Brown et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Commentary: Two-sample Mendelian randomization: opportunities and challenges
- (2016) Debbie A Lawlor INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique
- (2016) Fernando Pires Hartwig et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- Million Veteran Program: A mega-biobank to study genetic influences on health and disease
- (2016) John Michael Gaziano et al. JOURNAL OF CLINICAL EPIDEMIOLOGY
- Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study
- (2016) Sara L Pulit et al. LANCET NEUROLOGY
- Genomic analyses inform on migration events during the peopling of Eurasia
- (2016) Luca Pagani et al. NATURE
- Genome-wide association study identifies 74 loci associated with educational attainment
- (2016) Aysu Okbay et al. NATURE
- Genetics of complex traits: prediction of phenotype, identification of causal polymorphisms and genetic architecture
- (2016) M. E. Goddard et al. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- The phenotypic legacy of admixture between modern humans and Neandertals
- (2016) C. N. Simonti et al. SCIENCE
- A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features
- (2016) Kaustubh Adhikari et al. Nature Communications
- Explicating heterogeneity of complex traits has strong potential for improving GWAS efficiency
- (2016) Alexander M. Kulminski et al. Scientific Reports
- Accuracy of heritability estimations in presence of hidden population stratification
- (2016) Claire Dandine-Roulland et al. Scientific Reports
- Genome-wide patterns of selection in 230 ancient Eurasians
- (2015) Iain Mathieson et al. NATURE
- The fine-scale genetic structure of the British population
- (2015) Stephen Leslie et al. NATURE
- A global reference for human genetic variation
- (2015) Richard A. Gibbs et al. NATURE
- Genetic studies of body mass index yield new insights for obesity biology
- (2015) Adam E. Locke et al. NATURE
- LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
- (2015) Brendan K Bulik-Sullivan et al. NATURE GENETICS
- Efficient Bayesian mixed-model analysis increases association power in large cohorts
- (2015) Po-Ru Loh et al. NATURE GENETICS
- Genomic Heritability: What Is It?
- (2015) Gustavo de los Campos et al. PLoS Genetics
- Diversity in Clinical and Biomedical Research: A Promise Yet to Be Fulfilled
- (2015) Sam S. Oh et al. PLOS MEDICINE
- UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
- (2015) Cathie Sudlow et al. PLOS MEDICINE
- Describing the genetic architecture of epilepsy through heritability analysis
- (2014) Doug Speed et al. BRAIN
- Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus
- (2014) Yan Zhang et al. HUMAN MOLECULAR GENETICS
- Mendelian randomization: genetic anchors for causal inference in epidemiological studies
- (2014) G. Davey Smith et al. HUMAN MOLECULAR GENETICS
- The genomic landscape of Neanderthal ancestry in present-day humans
- (2014) Sriram Sankararaman et al. NATURE
- Relatedness in the post-genomic era: is it still useful?
- (2014) Doug Speed et al. NATURE REVIEWS GENETICS
- ADH1B and ADH1C Genotype, Alcohol Consumption and Biomarkers of Liver Function: Findings from a Mendelian Randomization Study in 58,313 European Origin Danes
- (2014) Debbie A. Lawlor et al. PLoS One
- Genomic selection: genome-wide prediction in plant improvement
- (2014) Zeratsion Abera Desta et al. TRENDS IN PLANT SCIENCE
- Genetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants
- (2014) Kalliope Panoutsopoulou et al. Nature Communications
- Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data
- (2014) M. V. Holmes et al. BMJ-British Medical Journal
- Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations
- (2014) Yun R Li et al. Genome Medicine
- Influenza Virus Drug Resistance: A Time-Sampled Population Genetics Perspective
- (2014) Matthieu Foll et al. PLoS Genetics
- Association of Chromosome 9p21 Genetic Variants with Risk of Coronary Heart Disease in the East Asian Population: A Meta-Analysis
- (2013) Liping Dong et al. ANNALS OF HUMAN GENETICS
- Exploring causal associations between alcohol and coronary heart disease risk factors: findings from a Mendelian randomization study in the Copenhagen General Population Study
- (2013) D. A. Lawlor et al. EUROPEAN HEART JOURNAL
- Higher Levels of Neanderthal Ancestry in East Asians than in Europeans
- (2013) Jeffrey D. Wall et al. GENETICS
- Prenatal alcohol exposure and offspring cognition and school performance. A ‘Mendelian randomization’ natural experiment
- (2013) Luisa Zuccolo et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- Correcting for Population Structure and Kinship Using the Linear Mixed Model: Theory and Extensions
- (2013) Gabriel E. Hoffman PLoS One
- Improved Heritability Estimation from Genome-wide SNPs
- (2012) Doug Speed et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Fine mapping of Xq28: bothMECP2 and IRAK1contribute to risk for systemic lupus erythematosus in multiple ancestral groups
- (2012) Kenneth M Kaufman et al. ANNALS OF THE RHEUMATIC DISEASES
- Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children
- (2012) Andy Boyd et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- Melanesian Blond Hair Is Caused by an Amino Acid Change in TYRP1
- (2012) E. E. Kenny et al. SCIENCE
- Inference of Population Structure using Dense Haplotype Data
- (2012) Daniel John Lawson et al. PLoS Genetics
- Population Structure Can Inflate SNP-Based Heritability Estimates
- (2011) Sharon R. Browning et al. AMERICAN JOURNAL OF HUMAN GENETICS
- A Comprehensive Genetic Association Study of Alzheimer Disease in African Americans
- (2011) Mark W. Logue ARCHIVES OF NEUROLOGY
- Strong Association of the Alcohol Dehydrogenase 1B Gene (ADH1B) with Alcohol Dependence and Alcohol-Induced Medical Diseases
- (2011) Dawei Li et al. BIOLOGICAL PSYCHIATRY
- Transethnic meta-analysis of genomewide association studies
- (2011) Andrew P. Morris GENETIC EPIDEMIOLOGY
- China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up
- (2011) Z. Chen et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- A common variant in the CDKN2B gene on chromosome 9p21 protects against coronary artery disease in Americans of African ancestry
- (2011) Brian G Kral et al. JOURNAL OF HUMAN GENETICS
- Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
- (2011) Heribert Schunkert et al. NATURE GENETICS
- Effect of Direct-to-Consumer Genomewide Profiling to Assess Disease Risk
- (2011) Cinnamon S. Bloss et al. NEW ENGLAND JOURNAL OF MEDICINE
- Accounting for Population Stratification in Practice: A Comparison of the Main Strategies Dedicated to Genome-Wide Association Studies
- (2011) Matthieu Bouaziz et al. PLoS One
- GCTA: A Tool for Genome-wide Complex Trait Analysis
- (2010) Jian Yang et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Admixture Mapping Comes of Age
- (2010) Cheryl A. Winkler et al. Annual Review of Genomics and Human Genetics
- A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses
- (2010) Samuli Ripatti et al. LANCET
- Mixed linear model approach adapted for genome-wide association studies
- (2010) Zhiwu Zhang et al. NATURE GENETICS
- Predicting genetic predisposition in humans: the promise of whole-genome markers
- (2010) Gustavo de los Campos et al. NATURE REVIEWS GENETICS
- Decanalization and the origin of complex disease
- (2009) Greg Gibson NATURE REVIEWS GENETICS
- Genome-Wide Association Studies in an Isolated Founder Population from the Pacific Island of Kosrae
- (2009) Jennifer K. Lowe et al. PLoS Genetics
- A Genealogical Interpretation of Principal Components Analysis
- (2009) Gil McVean PLoS Genetics
- Lactase persistence-related genetic variant: population substructure and health outcomes
- (2008) George Davey Smith et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Estimation of the multiple testing burden for genomewide association studies of nearly all common variants
- (2008) Itsik Pe'er et al. GENETIC EPIDEMIOLOGY
- Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study
- (2008) Abbas Dehghan et al. LANCET
- Genome-wide association studies for complex traits: consensus, uncertainty and challenges
- (2008) Mark I. McCarthy et al. NATURE REVIEWS GENETICS
- Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology
- (2007) Debbie A. Lawlor et al. STATISTICS IN MEDICINE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search