Role of cyclin‐dependent kinases (CDKs) in hepatocellular carcinoma: Therapeutic potential of targeting the CDK signaling pathway

A CRISPR screen identifies CDK7 as a therapeutic target in hepatocellular carcinoma

(2018) Cun Wang et al.   CELL RESEARCH

The Emerging Picture of CDK11: Genetic, Functional and Medicinal Aspects

(2018) Nikolas Ferreira dos Santos Paparidis et al.   CURRENT MEDICINAL CHEMISTRY

Immune checkpoint blockade for the treatment of human hepatocellular carcinoma

(2018) Naoshi Nishida et al.   HEPATOLOGY RESEARCH

Novel approaches for molecular targeted therapy against hepatocellular carcinoma

(2018) Yuji Eso et al.   HEPATOLOGY RESEARCH

Bafilomycin C1 induces G0/G1 cell-cycle arrest and mitochondrial-mediated apoptosis in human hepatocellular cancer SMMC7721 cells

(2018) Xiaoxiao Gao et al.   JOURNAL OF ANTIBIOTICS

Cyclin-dependent kinase 4/6 inhibitors as first-line treatment for post-menopausal metastatic hormone receptor-positive breast cancer patients: a systematic review and meta-analysis of phase III randomized clinical trials

(2018) Allan Ramos-Esquivel et al.   Breast Cancer

Recent advances in medical management of hepatocellular carcinoma

(2018) Kenji Ikeda   HEPATOLOGY RESEARCH

Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy

(2017) Jingying Zhou et al.   GUT

CDK20 inhibition and immune checkpoint blockade: bringing cancer biology and tumour immunology together to develop novel treatment options for HCC

(2017) Tim F Greten et al.   GUT

AASLD guidelines for the treatment of hepatocellular carcinoma

(2017) Julie K. Heimbach et al.   HEPATOLOGY

Up-regulation of CDK16 by multiple mechanisms in hepatocellular carcinoma promotes tumor progression

(2017) Yitao Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Bioinformatics analysis of key genes and pathways for hepatocellular carcinoma transformed from cirrhosis

(2017) Bosheng He et al.   MEDICINE

Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding

(2017) Peng Liao et al.   MOLECULAR CELL

CDK5 inhibitors prevent astroglial apoptosis and reactive astrogliosis by regulating PKA and DRP1 phosphorylations in the rat hippocampus

(2017) Hye-Won Hyun et al.   NEUROSCIENCE RESEARCH

Enterolactone Induces G1-phase Cell Cycle Arrest in Nonsmall Cell Lung Cancer Cells by Downregulating Cyclins and Cyclin-dependent Kinases

(2017) Shireen Chikara et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Immune Checkpoint Inhibition in Hepatocellular Carcinoma: Basics and Ongoing Clinical Trials

(2017) Masatoshi Kudo   ONCOLOGY

Impact of surgical treatment after sorafenib therapy for advanced hepatocellular carcinoma

(2017) Hideaki Takeyama et al.   SURGERY TODAY

Gene expression profiling, pathway analysis and subtype classification reveal molecular heterogeneity in hepatocellular carcinoma and suggest subtype specific therapeutic targets

(2017) Rahul Agarwal et al.   Cancer Genetics

Erratum: Cyclin I-like (CCNI2) is a cyclin-dependent kinase 5 (CDK5) activator and is involved in cell cycle regulation

(2017) Chengcheng Liu et al.   Scientific Reports

Clinical Development of the CDK4/6 Inhibitors Ribociclib and Abemaciclib in Breast Cancer

(2016) Romualdo Barroso-Sousa et al.   Breast Care

Anti-angiogenic effects of novel cyclin-dependent kinase inhibitors with a pyrazolo[4,3-d]pyrimidine scaffold

(2016) S Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

(Z)-3,5,4'-Trimethoxystilbene Limits Hepatitis C and Cancer Pathophysiology by Blocking Microtubule Dynamics and Cell-Cycle Progression

(2016) C. B. Nguyen et al.   CANCER RESEARCH

Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma

(2016) Julien Bollard et al.   GUT

Cyclin-Dependent Kinase 11 (CDK11) Is Required for Ovarian Cancer Cell Growth In Vitro and In Vivo , and Its Inhibition Causes Apoptosis and Sensitizes Cells to Paclitaxel

(2016) Xianzhe Liu et al.   MOLECULAR CANCER THERAPEUTICS

Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest

(2016) Hongwei Zhao et al.   ONCOLOGY RESEARCH

Cyclin-dependent protein kinase inhibitors including palbociclib as anticancer drugs

(2016) Robert Roskoski   PHARMACOLOGICAL RESEARCH

The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer

(2016) Yubing Zhou et al.   Oncotarget

A Novel CDK7 Inhibitor of the Pyrazolotriazine Class Exerts Broad-Spectrum Antiviral Activity at Nanomolar Concentrations

(2015) Corina Hutterer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Critical role of CDK11p58 in human breast cancer growth and angiogenesis

(2015) Yayun Chi et al.   BMC CANCER

Cyclin E1 Inhibition can Overcome Sorafenib Resistance in Hepatocellular Carcinoma Cells Through Mcl-1 Suppression

(2015) C. Hsu et al.   CLINICAL CANCER RESEARCH

FDA Approval: Palbociclib for the Treatment of Postmenopausal Patients with Estrogen Receptor-Positive, HER2-Negative Metastatic Breast Cancer

(2015) J. A. Beaver et al.   CLINICAL CANCER RESEARCH

Two Degradation Pathways of the p35 Cdk5 (Cyclin-dependent Kinase) Activation Subunit, Dependent and Independent of Ubiquitination

(2015) Toshiyuki Takasugi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synergistic anti-tumor efficacy of doxorubicin and flavopiridol in an in vivo hepatocellular carcinoma model

(2015) Min-Sun Kwak et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients

(2015) Hai Feng et al.   JOURNAL OF HEPATOLOGY

Targeting cyclin dependent kinase 5 in hepatocellular carcinoma – A novel therapeutic approach

(2015) Sandra M. Ehrlich et al.   JOURNAL OF HEPATOLOGY

The history and future of targeting cyclin-dependent kinases in cancer therapy

(2015) Uzma Asghar et al.   NATURE REVIEWS DRUG DISCOVERY

PFTK1 Promotes Gastric Cancer Progression by Regulating Proliferation, Migration and Invasion

(2015) Lei Yang et al.   PLoS One

Targeting Cyclin-Dependent Kinases and Cell Cycle Progression in Human Cancers

(2015) Loredana Santo et al.   SEMINARS IN ONCOLOGY

An immunohistochemical study of cyclin-dependent kinase 5 (CDK5) expression in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC): a possible prognostic biomarker

(2015) Kanglai Wei et al.   World Journal of Surgical Oncology

TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway

(2015) Hong-Pei Yu et al.   Scientific Reports

Tissue Microarray Immunohistochemical Profiles of p53 and pRB in Hepatocellular Carcinoma and Hepatoblastoma

(2014) Abdul Hadi Azlin et al.   Asian Pacific Journal of Cancer Prevention

Antitumor Effects in Hepatocarcinoma of Isoform-Selective Inhibition of HDAC2

(2014) Yun-Han Lee et al.   CANCER RESEARCH

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma

(2014) Chun-Hao Huang et al.   GENES & DEVELOPMENT

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

(2014) Nicholas Kwiatkowski et al.   NATURE

Integrated Analysis of Whole Genome and Transcriptome Sequencing Reveals Diverse Transcriptomic Aberrations Driven by Somatic Genomic Changes in Liver Cancers

(2014) Yuichi Shiraishi et al.   PLoS One

Cyclin-dependent kinases

(2014) Marcos Malumbres   GENOME BIOLOGY

The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations

(2014) Xavier Bisteau et al.   Cancers

UCN-01 induces S and G2/M cell cycle arrest through the p53/p21waf1or CHK2/CDC25C pathways and can suppress invasion in human hepatoma cell lines

(2013) Guoyi Wu et al.   BMC CANCER

Clinical implications of deregulated CDK4 and Cyclin D1 expression in patients with human hepatocellular carcinoma

(2013) Jeng-Wei Lu et al.   MEDICAL ONCOLOGY

The role of CDK1 in apoptin-induced apoptosis in hepatocellular carcinoma cells

(2013) JING ZHAO et al.   ONCOLOGY REPORTS

The cyclin K/Cdk12 complex

(2012) Dalibor Blazek   CELL CYCLE

Systematic Kinome shRNA Screening Identifies CDK11 (PITSLRE) Kinase Expression Is Critical for Osteosarcoma Cell Growth and Proliferation

(2012) Z. Duan et al.   CLINICAL CANCER RESEARCH

Clinical and biological significance of Cdk10 in hepatocellular carcinoma

(2012) Xiang-yu Zhong et al.   GENE

Cyclin-dependent kinase-associated protein phosphatase is overexpressed in alcohol-related hepatocellular carcinoma and influences xenograft tumor growth

(2012) WEY-RAN LIN et al.   ONCOLOGY REPORTS

Frequent Amplification of CENPF, GMNN and CDK13 Genes in Hepatocellular Carcinomas

(2012) Hye-Eun Kim et al.   PLoS One

Cyclin K goes with Cdk12 and Cdk13

(2012) Jiri Kohoutek et al.   Cell Division

Anti-proliferative effects of anandamide in human hepatocellular carcinoma cells

(2012) CHENGZHI XIE et al.   Oncology Letters

A phase I pharmacokinetic and pharmacodynamic study of AT7519, a cyclin-dependent kinase inhibitor in patients with refractory solid tumors

(2011) D. Mahadevan et al.   ANNALS OF ONCOLOGY

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

(2011) D. Blazek et al.   GENES & DEVELOPMENT

Cyclin-dependent Kinase-5 Is a Key Molecule in Tumor Necrosis Factor-α-induced Insulin Resistance

(2011) Atsushi Nohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ibulocydine Is a Novel Prodrug Cdk Inhibitor That Effectively Induces Apoptosis in Hepatocellular Carcinoma Cells

(2011) Seung-Ju Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell cycle–related kinase is a direct androgen receptor–regulated gene that drives β-catenin/T cell factor–dependent hepatocarcinogenesis

(2011) Hai Feng et al.   JOURNAL OF CLINICAL INVESTIGATION

Combination of flavopiridol and embelin effectively inhibit cell growth in hepatocellular carcinoma depending on regulatory relationship between CDK6 and XIAP

(2011) Yufang Che et al.   MEDICINAL CHEMISTRY RESEARCH

Hypoxia and retinoic acid-inducible NDRG1 expression is responsible for doxorubicin and retinoic acid resistance in hepatocellular carcinoma cells

(2010) Eun Uk Jung et al.   CANCER LETTERS

Phase I evaluation of seliciclib (R-roscovitine), a novel oral cyclin-dependent kinase inhibitor, in patients with advanced malignancies

(2010) Christophe Le Tourneau et al.   EUROPEAN JOURNAL OF CANCER

Proliferative Suppression by CDK4/6 Inhibition: Complex Function of the Retinoblastoma Pathway in Liver Tissue and Hepatoma Cells

(2010) Dayana B. Rivadeneira et al.   GASTROENTEROLOGY

Cyclin-dependent Kinase 5 Regulates Endothelial Cell Migration and Angiogenesis

(2010) Johanna Liebl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted disruption of Nemo-like kinase inhibits tumor cell growth by simultaneous suppression of cyclin D1 and CDK2 in human hepatocellular carcinoma

(2010) Kwang Hwa Jung et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis

(2010) Yan Wang et al.   JOURNAL OF HEPATOLOGY

Binding to DNA of the RNA-polymerase II C-terminal domain allows discrimination between Cdk7 and Cdk9 phosphorylation

(2009) G. Lolli   NUCLEIC ACIDS RESEARCH

Molecular mechanism underlying the functional loss of cyclindependent kinase inhibitors p16 and p27 in hepatocellular carcinoma

(2008) Yasunobu Matsuda   WORLD JOURNAL OF GASTROENTEROLOGY