Article
Neurosciences
Elizabeth L. Steuer, Lisa J. Kemper, Chris J. W. Hlynialuk, Kailee Leinonen-Wright, Michelle L. Montonye, Ian P. Lapcinski, Colleen L. Forster, Karen H. Ashe, Peng Liu
Summary: A study on genetically matched htau targeted-insertion mouse lines shows that blocking htau cleavage at D314 can delay neurodegeneration and cognitive deficits associated with frontotemporal dementia (FTD), providing insights into the pathology and potential treatments for dementia.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Gastroenterology & Hepatology
Mincheng Yu, Zheng Chen, Qiang Zhou, Bo Zhang, Jinlong Huang, Lei Jin, Binghai Zhou, Shuang Liu, Jiuliang Yan, Xiaoqiang Li, Wentao Zhang, Chunxiao Liu, Bo Hu, Peiyao Fu, Chenhao Zhou, Yongfeng Xu, Yongsheng Xiao, Jian Zhou, Jia Fan, Ning Ren, Mien-Chie Hung, Lei Guo, Hui Li, Qinghai Ye
Summary: PARG plays an oncogenic role in HCC by modulating the PARG/DDB1/c-Myc signaling pathway. Targeting PARG in combination with anti-PD-1 therapy shows promising therapeutic efficacy in HCC.
JOURNAL OF HEPATOLOGY
(2022)
Article
Plant Sciences
Jiaqi Li, Zongjin Wu, Geer Chen, Xiaoxuan Wang, Xiaoyu Zhu, Yao Zhang, Ren Zhang, Weiyu Wu, Yizhun Zhu, Lijuan Ma, Haijie Yu
Summary: In this study, it was found that Formosanin C (FC), a diosgenin derived from a medicinal plant, can inhibit the growth and metastasis of lung cancer through inhibiting lactate transport and disrupting mitochondrial functions.
Article
Biochemistry & Molecular Biology
Xiaodong Zhang, Fangyu Hu, Baiwang Zhu, Xueli Jiao, Yun Li, Shuang Wu, Ganglin Ren, Jizhen Li, Qipeng Xie, Yifei Pan, Hongyan Li, Lingling Zhao
Summary: This study investigates the role of TEX11 gene in colorectal cancer (CRC). The results show that TEX11 expression is significantly downregulated in clinical samples and cell lines, and is associated with poor prognosis in CRC patients. Further experiments demonstrate that TEX11 can inhibit the proliferative capacity of CRC cells. Mechanistically, TEX11 promotes COP1 transcription by upregulating FOXO3a expression, thus accelerating the degradation of the negative transcriptional regulator c-Jun and enhancing p21 transcription, leading to inhibition of CRC cell proliferation.
Review
Neurosciences
Marcos Martinez-Banaclocha
Summary: Parkinson's disease is a prevalent age-related neurodegenerative disorder, with the majority of cases being sporadic, though a small percentage are associated with gene mutations. Environmental toxic substances and individual genetic susceptibility play a role in the onset of the disease. Despite efforts to treat and prevent Parkinson's disease, the pathophysiological mechanisms leading to its onset and progression are not fully understood.
Article
Cell Biology
Yining Hao, Yu Zhu, Fukang Sun, Danfeng Xu, Chenghe Wang
Summary: miR-30c-5p is significantly downregulated in bladder cancer (BCa) and is associated with unfavorable TNM stages and poor prognosis. It exerts its function in BCa by suppressing its target gene PRC1. Thus, miR-30c-5p has the potential to be a valuable biomarker for predicting clinical outcomes in BCa patients.
CELLULAR SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Myungyeon Lee, Na Yeon Ham, Chi Yeon Hwang, Jiwon Jang, Boram Lee, Joo-Won Jeong, Insug Kang, Eui-Ju Yeo
Summary: Compound C inhibits the viability and migration of renal carcinoma cells by blocking cell cycle progression and platelet-derived growth factor receptor signaling pathways. It shows therapeutic potential against tumor development and progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Samar Samir Youssef, Eman Abd El Razek Abbas, Rana Ahmed Youness, Moustafa Nouh Elemeery, Amal Soliman Nasr, Sameh Seif
Summary: IL28B rs8099917 and PNPLA3 rs738409 polymorphisms are associated with susceptibility to CHC and fibrosis progression in CHC G4. The CC-GG (PNPLA3-IL28B) haplotype is a high-risk signature for CHC infection susceptibility, while the GG-GG (PNPLA3-IL28B) haplotype is a high-risk signature for higher degree of fibrosis.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Nikola Andelic, Ivan Lorencin, Sandi Baressi Segota, Zlatan Car
Summary: In this paper, a mathematical equation based on the GPSC algorithm was developed to accurately detect Hepatitis C patients and the progression of Hepatitis C, Fibrosis, and Cirrhosis. Imbalanced dataset issues were addressed using various methods. The symbolic expressions were evaluated using cross-validation and hyperparameter search. The best results were achieved with a dataset balanced with the Borderline SMOTE method in both binary and multi-class cases.
APPLIED SCIENCES-BASEL
(2023)
Article
Medicine, Research & Experimental
Ya-Wen Hsiao, Fai-Meng Sou, Jing-Houng Wang, Yen-Hao Chen, Ming-Chao Tsai, Tsung-Hui Hu, Chao-Hung Hung, Chien-Hung Chen, Yuan-Hung Kuo
Summary: The study found that well-controlled viremia is associated with better survival rates and reduced tumor progression risk in patients with unresectable HCC receiving Lenvatinib treatment.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Manal R. Mohammed, Azza M. El-Bahkery, Shereen M. Shedid
Summary: Most studies on the biological effects of ionizing radiation have focused on a single acute dose, while in reality, exposures usually occur under chronic or repetitive conditions. This study compared the effects of repetitive and acute exposure in a rat model and found that the dose and pattern of ionizing radiation have significant impacts on gene expression and cell function.
Article
Gastroenterology & Hepatology
Yanhui Xu, Wenqian Qi, Xu Wang, Yonggui Zhang, Liang Han, Jingyi Shi, Guohua Wang, Jia Liu, Honglei Duan, Xianling Cong, Ping Zhao, Changyu Zhou, Jiangbin Wang
Summary: This study aimed to investigate the role of the AR/CCRK signaling pathway in chronic HBV infection and gender differences, and the contribution of the AR regulatory factor STAT3. The study found significantly higher expression levels of AR, CCRK, and p-STAT3 in liver tissues of HBV-infected patients compared with controls. The expression levels were also correlated with disease severity and showed gender differences.
JOURNAL OF VIRAL HEPATITIS
(2022)
Article
Medicine, General & Internal
V. A. Kovaleva, N. S. Zhevnerova, T. Antonova
Summary: The study revealed significant relationship between disturbances in carbohydrate-lipid metabolism and liver fibrosis, as well as the level of galectin-3 and fibrosis stage of the liver. The prognostic value of increasing galectin-3 levels for predicting the cirrhotic stage of liver fibrosis is supported.
TERAPEVTICHESKII ARKHIV
(2021)
Article
Oncology
Shiva Mosadegh Manshadi, Fatemeh Nadali, Mohammad Reza Shams Ardekani
Summary: This study demonstrated that the hydro-alcoholic extract of Prunus armeniaca has antitumor effects on breast cancer cell lines by inhibiting the cell cycle progression at the G0/G1 phase and inducing apoptosis.
MIDDLE EAST JOURNAL OF CANCER
(2021)
Article
Medicine, General & Internal
H. V. Venytska, O. Riabokon, Yu. Yu. Riabokon, R. O. Shcherbyna
Summary: The aim of this study was to determine the diagnostic values of serum MMP-9 and TGF-1 & beta; for assessing the severity and progression rate of liver fibrosis in patients with CHC GT1 infection. 92 patients were examined, and the severity of liver fibrosis was assessed using elastometry. The levels of TGF-1 & beta; and MMP-9 in the serum were measured using the ELISA method. The results showed that higher levels of TGF-1 & beta; and lower levels of MMP-9 were associated with more severe liver fibrosis and faster progression rate.
ZAPOROZHYE MEDICAL JOURNAL
(2023)
Article
Oncology
Xiangyan Wu, Dongfeng Qu, Nathaniel Weygant, Jun Peng, Courtney W. Houchen
Article
Oncology
Anita L. Ray, Robert A. Nofchissey, Maaz A. Khan, Megan A. Reidy, Megan R. Lerner, Xiangyan Wu, Shaoxuan Guo, Spencer L. Hill, Nathaniel Weygant, Sarah F. Adams, Eliseo F. Castillo, William L. Berry, Michael B. Stout, Katherine T. Morris
BRITISH JOURNAL OF CANCER
(2020)
Article
Cell Biology
Zeyu Wang, Guanhua Su, Ziyu Dai, Ming Meng, Hao Zhang, Fan Fan, Zhengzheng Liu, Longbo Zhang, Nathaniel Weygant, Fengqiong He, Ning Fang, Liyang Zhang, Quan Cheng
Summary: Circadian clock gene expression in glioma is associated with disease progression, affecting the tumor immune landscape and cell cycle, potentially impacting survival outcomes. A risk model can predict glioma survival outcomes and may be applicable to other types of cancer.
CELL PROLIFERATION
(2021)
Article
Gastroenterology & Hepatology
Nathaniel Weygant, Karen Chang, Christian S. Jackson, Kenneth J. Vega
Summary: This study used the TCGA EC dataset to analyze whether survival rates vary by sex in esophageal cancer patients, finding that male patients have lower survival rates, and some genetic alterations are dysregulated in patients of different sexes.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Review
Oncology
Zhiyun Cao, Nathaniel Weygant, Parthasarathy Chandrakesan, Courtney W. Houchen, Jun Peng, Dongfeng Qu
Article
Oncology
Liyang Zhang, Fangkun Liu, Nathaniel Weygant, Junxia Zhang, Ping Hu, Zailong Qin, Jingxuan Yang, Quan Cheng, Fan Fan, Yu Zeng, Yongjian Tang, Yusheng Li, Anliu Tang, Fengqiong He, Jun Peng, Weihua Liao, Zhongliang Hu, Min Li, Zhixiong Liu
Summary: Researchers developed an integrated system using patient-derived glioma cerebral organoids and xenograft models to understand glioma biology and predict response to chemotherapy drugs, providing a new strategy for personalized treatment of this deadly disease.
Review
Cell Biology
Xingmin Wang, Ram Babu Undi, Naushad Ali, Mark M. Huycke
Summary: Sporadic colorectal cancer (CRC) is a major cause of global cancer mortality, with the gut microbiota recently recognized as a significant contributing factor. The microbiota-induced bystander effect (MIBE) is a newly described cancer mechanism where microbiota-driven parainflammation leads to the cancerous transformation of colon epithelial cells. Understanding the interactions between gut microbiota and mucosal immune effector cells that generate bystander effects may offer insights into CRC prevention.
DISEASE MODELS & MECHANISMS
(2021)
Review
Oncology
Ling Ding, Yuning Yang, Qin Lu, Zhiyun Cao, Nathaniel Weygant
Summary: This review summarizes the application of human colorectal cancer patient-derived organoids (PDOs) in the study of cancer stem cells (CSCs) and the cancer stem cell niche. It focuses on the relevance of PDOs in understanding CSC-related signaling, interactions between CSCs and the tumor microenvironment, and the modeling of CSC-driven resistance to therapies.
CURRENT CANCER DRUG TARGETS
(2022)
Article
Oncology
Yang Ge, Xiaona Fan, Xuying Huang, Nathaniel Weygant, Zeru Xiao, Rui Yan, Heshu Liu, Jian Liu, Guangyu An, Jiannan Yao
Summary: DCLK1-S expression is significantly increased in human esophageal squamous cell carcinoma (ESCC) tissues and is associated with malignant progression and poor prognosis. Functional studies showed that DCLK1-S plays a role in promoting ESCC cell proliferation, migration, and invasion, potentially through the MAPK/ERK/MMP2 pathway. These findings suggest that DCLK1-S may serve as a biomarker or therapeutic target for improving outcomes in patients with ESCC.
MOLECULAR CANCER RESEARCH
(2021)
Article
Oncology
Ling Ding, Yuning Yang, Yang Ge, Qin Lu, Zixing Yan, Xuzheng Chen, Jian Du, Sassan Hafizi, Xiaohui Xu, Jiannan Yao, Jian Liu, Zhiyun Cao, Nathaniel Weygant
Summary: This study demonstrates that the small molecule kinase inhibitor DCLK1-IN-1 effectively inhibits DCLK1 phosphorylation and stemness related properties of RCC cells, showing potential as an immunotherapy agent and in combination therapy with anti-PD1. Clinical analysis suggests that DCLK1 predicts RCC survival and its expression is correlated with immune cell infiltration and immunosuppressive macrophage populations.
Article
Virology
Ram Babu Undi, Jason L. Larabee, Adrian Filiberti, Susanna Ulahannan, Sheeja Aravindan, Edana Stroberg, Lisa M. Barton, Eric J. Duval, Sanjay Mukhopadhyay, James C. Henthorn, Darrin Akins, Courtney W. Houchen, Mark M. Huycke, Naushad Ali
Summary: COVID-19 mortality is higher in patients with underlying comorbidities such as chronic liver diseases. This study shows that DCLK1 plays a crucial role in enhancing SARS-CoV-2 viremia, inflammatory cytokine expression, and dysregulation of immune cells involved in innate immunity. DCLK1 may be a potential therapeutic target for COVID-19, especially in patients with comorbidities associated with DCLK1 expression.
JOURNAL OF VIROLOGY
(2022)
Review
Oncology
Ram Babu Undi, Adrian Filiberti, Naushad Ali, Mark M. Huycke
Summary: Inflammation is a key characteristic of cancer, and macrophages play a crucial role in chronic inflammation, parainflammation, and inflammaging. Regardless of whether it is induced by infection, injury, or aging, immune dysregulation and chronic macrophage polarization contribute to cancer initiation by producing proinflammatory chemokines/cytokines and genotoxins, and by modulating immune surveillance. This review presents both pre-clinical and clinical evidence supporting polarized macrophages as endogenous cellular carcinogens in the context of chronic inflammation, parainflammation, and inflammaging. Additionally, emerging strategies for cancer prevention targeting macrophage function and phenotype, such as small molecule inhibitors and probiotic approaches, are discussed.
Article
Biochemistry & Molecular Biology
Ling Ding, Yuning Yang, Qin Lu, Dongfeng Qu, Parthasarathy Chandrakesan, Hailan Feng, Hong Chen, Xuzheng Chen, Zhuhui Liao, Jian Du, Zhiyun Cao, Nathaniel Weygant
Summary: This study investigates the function and mechanism of bufalin against colorectal cancer stemness. The results demonstrate that bufalin inhibits CRC stemness by targeting the C-Kit/Slug signaling axis, leading to inhibited CRC growth and progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Ling Zhang, Qiaoyan Cai, Shan Lin, Bin Chen, Beibei Jia, Renzhi Ye, Nathaniel Weygant, Jianfeng Chu, Jun Peng
Summary: The study demonstrates that Qingda granule has a significant neuroprotective effect on ischemic stroke, improving neurobehavioral deficits, reducing neuron loss, and inhibiting apoptosis. Furthermore, Qingda granule acts through modulating the lncRNA GAS5/miR-137 signaling pathway.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jiannan Yao, Xinying Xue, Dongfeng Qu, C. Benedikt Westphalen, Yang Ge, Liyang Zhang, Manyu Li, Tianbo Gao, Parthasarathy Chandrakesan, Kenneth J. Vega, Jun Peng, Guangyu An, Nathaniel Weygant
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2020)