Do BACE inhibitor failures in Alzheimer’s patients challenge the amyloid hypothesis of the disease?
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Do BACE inhibitor failures in Alzheimer’s patients challenge the amyloid hypothesis of the disease?
Authors
Keywords
-
Journal
Expert Review of Neurotherapeutics
Volume -, Issue -, Pages 1-4
Publisher
Informa UK Limited
Online
2019-05-22
DOI
10.1080/14737175.2019.1621751
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Amyloid-β Immunotherapy for Alzheimer's Disease - Is It Now A Long Shot…?
- (2019) Francesco Panza et al. ANNALS OF NEUROLOGY
- A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease
- (2019) Francesco Panza et al. Nature Reviews Neurology
- Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6
- (2018) Kaichuan Zhu et al. BIOLOGICAL PSYCHIATRY
- Role of Amyloid-β and Tau Proteins in Alzheimer’s Disease: Confuting the Amyloid Cascade
- (2018) Walter Gulisano et al. JOURNAL OF ALZHEIMERS DISEASE
- Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease
- (2018) Michael F. Egan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Microbes and Alzheimer’s Disease: New Findings Call for a Paradigm Change
- (2018) Jürgen G. Haas et al. TRENDS IN NEUROSCIENCES
- Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer’s Disease
- (2018) Amanda L. Lumsden et al. Frontiers in Neuroscience
- Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer’s disease
- (2018) Gary P. Morris et al. ACTA NEUROPATHOLOGICA
- Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease
- (2018) Miia Kivipelto et al. Nature Reviews Neurology
- Amyloid-β Peptide Is Needed for cGMP-Induced Long-Term Potentiation and Memory
- (2017) Agostino Palmeri et al. JOURNAL OF NEUROSCIENCE
- Amyloid-β as a Modulator of Synaptic Plasticity
- (2017) Mordhwaj S. Parihar et al. JOURNAL OF ALZHEIMERS DISEASE
- A Physiological Role for Amyloid-β Protein: Enhancement of Learning and Memory
- (2017) John E. Morley et al. JOURNAL OF ALZHEIMERS DISEASE
- Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase
- (2016) Linfeng Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Alzheimer’s disease due to loss of function: A new synthesis of the available data
- (2016) Kasper P. Kepp PROGRESS IN NEUROBIOLOGY
- Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions
- (2015) Severin Filser et al. BIOLOGICAL PSYCHIATRY
- Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling
- (2015) Xiangyou Hu et al. JOURNAL OF NEUROCHEMISTRY
- The keystone of Alzheimer pathogenesis might be sought in Aβ physiology
- (2015) D. Puzzo et al. NEUROSCIENCE
- Targeting Prodromal Alzheimer Disease With Avagacestat
- (2015) Vladimir Coric et al. JAMA Neurology
- Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects
- (2014) Robert Vassar et al. JOURNAL OF NEUROCHEMISTRY
- Regulation of Presynaptic Ca2+, Synaptic Plasticity and Contextual Fear Conditioning by a N-terminal -Amyloid Fragment
- (2014) J. L. M. Lawrence et al. JOURNAL OF NEUROSCIENCE
- A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
- (2013) Rachelle S. Doody et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety and Tolerability of the γ-Secretase Inhibitor Avagacestat in a Phase 2 Study of Mild to Moderate Alzheimer Disease
- (2012) Vladimir Coric et al. ARCHIVES OF NEUROLOGY
- β-Site Amyloid Precursor Protein (APP)-cleaving Enzyme 1 (BACE1)-deficient Mice Exhibit a Close Homolog of L1 (CHL1) Loss-of-function Phenotype Involving Axon Guidance Defects
- (2012) Brian Hitt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease
- (2011) S. Salloway et al. NEUROLOGY
- Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory
- (2010) Daniela Puzzo et al. ANNALS OF NEUROLOGY
- A γ-secretase inhibitor decreases amyloid-β production in the central nervous system
- (2009) Randall J. Bateman et al. ANNALS OF NEUROLOGY
- Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer DiseaseA Randomized Controlled Trial
- (2009) Robert C. Green JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses
- (2009) Efrat Abramov et al. NATURE NEUROSCIENCE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now