Nucleoskeletal regulation of transcription: Actin on MRTF

Messages from the voices within: regulation of signaling by proteins of the nuclear lamina

(2018) Larry Gerace et al.   CURRENT OPINION IN CELL BIOLOGY

Differential incorporation of SUN-domain proteins into LINC complexes is coupled to gene expression

(2018) Christopher K. May et al.   PLoS One

The nuclear actin-containing Arp8 module is a linker DNA sensor driving INO80 chromatin remodeling

(2018) Kilian R. Knoll et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Nature of Actin-Family Proteins in Chromatin-Modifying Complexes

(2018) Naeh L. Klages-Mundt et al.   Frontiers in Genetics

LAP2 Proteins Chaperone GLI1 Movement between the Lamina and Chromatin to Regulate Transcription

(2018) Amar N. Mirza et al.   CELL

The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ

(2018) Lei Chang et al.   NATURE

Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics

(2017) Charles T. Foster et al.   GENES & DEVELOPMENT

Substrate stiffness-dependent regulation of the SRF−Mkl1 co-activator complex requires the inner nuclear membrane protein Emerin

(2017) Margaret K. Willer et al.   JOURNAL OF CELL SCIENCE

Opposing roles for distinct LINC complexes in regulation of the small GTPase RhoA

(2017) Ketan Thakar et al.   MOLECULAR BIOLOGY OF THE CELL

Myocardin-related transcription factors are required for skeletal muscle development

(2016) Bercin K. Cenik et al.   DEVELOPMENT

MRTF potentiates TEAD‐YAP transcriptional activity causing metastasis

(2016) Tackhoon Kim et al.   EMBO JOURNAL

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

YAP Nuclear Localization in the Absence of Cell-Cell Contact Is Mediated by a Filamentous Actin-dependent, Myosin II- and Phospho-YAP-independent Pathway during Extracellular Matrix Mechanosensing

(2016) Arupratan Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Persistent nuclear actin filaments inhibit transcription by RNA polymerase II

(2016) Leonid A. Serebryannyy et al.   JOURNAL OF CELL SCIENCE

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment

(2016) Huy Quang Le et al.   NATURE CELL BIOLOGY

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Stress-dependent phosphorylation of myocardin-related transcription factor A (MRTF-A) by the p38MAPK/MK2 axis

(2016) Natalia Ronkina et al.   Scientific Reports

Nuclear actin modulates cell motility via transcriptional regulation of adhesive and cytoskeletal genes

(2016) Amir S. Sharili et al.   Scientific Reports

Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

(2016) Richard Panayiotou et al.   eLife

Nuclear F-actin Formation and Reorganization upon Cell Spreading

(2015) Matthias Plessner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix Rigidity Mediates TGFβ1-induced Epithelial-Myofibroblast Transition by Controlling Cytoskeletal Organization and MRTF-A Localization

(2015) Joseph W. O'Connor et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy

(2015) Takeshi Shimi et al.   MOLECULAR BIOLOGY OF THE CELL

Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration

(2015) Philipp Kircher et al.   Science Signaling

RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1

(2015) Eeva Kaisa Rajakylä et al.   Nature Communications

Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration

(2015) Philipp Kircher et al.   Science Signaling

Redox Modification of Nuclear Actin by MICAL-2 Regulates SRF Signaling

(2014) Mark R. Lundquist et al.   CELL

Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts

(2014) C. Esnault et al.   GENES & DEVELOPMENT

The nuclear lamina is mechano-responsive to ECM elasticity in mature tissue

(2014) J. Swift et al.   JOURNAL OF CELL SCIENCE

Targeted Ablation of Nesprin 1 and Nesprin 2 from Murine Myocardium Results in Cardiomyopathy, Altered Nuclear Morphology and Inhibition of the Biomechanical Gene Response

(2014) Indroneal Banerjee et al.   PLoS Genetics

Direct actin binding to A- and B-type lamin tails and actin filament bundling by the lamin A tail

(2014) Dan N. Simon et al.   Nucleus

Structural insights into LINC complexes

(2013) Brian A Sosa et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Steady-state nuclear actin levels are determined by export competent actin pool

(2013) Kari-Pekka Skarp et al.   Cytoskeleton

Analysis of nuclear actin by overexpression of wild-type and actin mutant proteins

(2013) Enikö Kokai et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Differences in the Nuclear Export Mechanism between Myocardin and Myocardin-related Transcription Factor A

(2013) Ken'ichiro Hayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lamin A/C and emerin regulate MKL1–SRF activity by modulating actin dynamics

(2013) Chin Yee Ho et al.   NATURE

To be or not to be assembled: progressing into nuclear actin filaments

(2013) Robert Grosse et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evidence for monomeric actin function in INO80 chromatin remodeling

(2013) Prabodh Kapoor et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nuclear Actin Network Assembly by Formins Regulates the SRF Coactivator MAL

(2013) C. Baarlink et al.   SCIENCE

Inhibition of TGF-  Signaling at the Nuclear Envelope: Characterization of Interactions Between MAN1, Smad2 and Smad3, and PPM1A

(2013) B. Bourgeois et al.   Science Signaling

Lamina-associated polypeptide (LAP)2α and nucleoplasmic lamins in adult stem cell regulation and disease

(2013) Kevin Gesson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mechanisms of nuclear actin in chromatin-remodeling complexes

(2013) Prabodh Kapoor et al.   TRENDS IN CELL BIOLOGY

The nuclear envelope LEM-domain protein emerin

(2013) Jason M Berk et al.   Nucleus

Matrix Stiffness–Induced Myofibroblast Differentiation Is Mediated by Intrinsic Mechanotransduction

(2012) Xiangwei Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Active maintenance of nuclear actin by importin 9 supports transcription

(2012) J. Dopie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural biochemistry of nuclear actin-related proteins 4 and 8 reveals their interaction with actin

(2011) Sebastian Fenn et al.   EMBO JOURNAL

Nuclear transport of the serum response factor coactivator MRTF-A is downregulated at tensional homeostasis

(2011) Karen M McGee et al.   EMBO REPORTS

G-actin Participates in RNA Polymerase II-dependent Transcription Elongation by Recruiting Positive Transcription Elongation Factor b (P-TEFb)

(2011) Tianyang Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Interaction between Nesprins and Sun Proteins at the Nuclear Envelope Is Critical for Force Transmission between the Nucleus and Cytoskeleton

(2011) Maria L. Lombardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleoskeleton mechanics at a glance

(2011) K. N. Dahl et al.   JOURNAL OF CELL SCIENCE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

The nucleoskeleton as a genome-associated dynamic 'network of networks'

(2011) Dan N. Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of a Pentavalent G-Actin*MRTF-A Complex Reveals How G-Actin Controls Nucleocytoplasmic Shuttling of a Transcriptional Coactivator

(2011) S. Mouilleron et al.   Science Signaling

Interactions Between Nuclei and the Cytoskeleton Are Mediated by SUN-KASH Nuclear-Envelope Bridges

(2010) Daniel A. Starr et al.   Annual Review of Cell and Developmental Biology

An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A

(2010) Rafał Pawłowski et al.   EMBO JOURNAL

Activation and Repression of Cellular Immediate Early Genes by Serum Response Factor Cofactors

(2010) Seung-Min Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Depletion of nuclear actin is a key mediator of quiescence in epithelial cells

(2010) V. A. Spencer et al.   JOURNAL OF CELL SCIENCE

Myocardin-Related Transcription Factor A Is a Common Mediator of Mechanical Stress- and Neurohumoral Stimulation-Induced Cardiac Hypertrophic Signaling Leading to Activation of Brain Natriuretic Peptide Gene Expression

(2010) K. Kuwahara et al.   MOLECULAR AND CELLULAR BIOLOGY

Linking actin dynamics and gene transcription to drive cellular motile functions

(2010) Eric N. Olson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells

(2009) Bo Wen et al.   NATURE GENETICS

Nuclear actin dynamics - From form to function

(2008) Maria K. Vartiainen   FEBS LETTERS

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

(2008) T. Dechat et al.   GENES & DEVELOPMENT

The Histone Acetyltransferase PCAF Associates with Actin and hnRNP U for RNA Polymerase II Transcription

(2008) A. Obrdlik et al.   MOLECULAR AND CELLULAR BIOLOGY

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

(2008) Lars Guelen et al.   NATURE