Matrix Rigidity Mediates TGFβ1-induced Epithelial-Myofibroblast Transition by Controlling Cytoskeletal Organization and MRTF-A Localization

RPEL Proteins Are the Molecular Targets for CCG-1423, an Inhibitor of Rho Signaling

(2014) Ken’ichiro Hayashi et al.   PLoS One

Novel Rho/MRTF/SRF Inhibitors Block Matrix-stiffness and TGF-β–Induced Fibrogenesis in Human Colonic Myofibroblasts

(2013) Laura A. Johnson et al.   INFLAMMATORY BOWEL DISEASES

Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis

(2013) Yong Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

Cell Adhesion and Shape Regulate TGF-Beta1-Induced Epithelial-Myofibroblast Transition via MRTF-A Signaling

(2013) Joseph W. O’Connor et al.   PLoS One

Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility

(2013) N. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix Stiffness–Induced Myofibroblast Differentiation Is Mediated by Intrinsic Mechanotransduction

(2012) Xiangwei Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Adhesion Regulates MAP Kinase/Ternary Complex Factor Exchange to Control a Proliferative Transcriptional Switch

(2012) Michele A. Wozniak et al.   CURRENT BIOLOGY

Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin αvβ6-dependent physical force

(2012) Marilyn M. Giacomini et al.   EXPERIMENTAL CELL RESEARCH

Directing epithelial to mesenchymal transition through engineered microenvironments displaying orthogonal adhesive and mechanical cues

(2012) Marilyn C. Markowski et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosis-associated epithelial-to-mesenchymal transitions

(2012) Ashley C Brown et al.   JOURNAL OF PATHOLOGY

Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition

(2012) Jennifer L. Leight et al.   MOLECULAR BIOLOGY OF THE CELL

Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis

(2011) Cecilia Marmai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Matrix compliance and RhoA direct the differentiation of mammary progenitor cells

(2011) Cecillia Lui et al.   Biomechanics and Modeling in Mechanobiology

In situ force mapping of mammary gland transformation

(2011) Jose I. Lopez et al.   Integrative Biology

Identification of Epithelial to Mesenchymal Transition as a Novel Source of Fibroblasts in Intestinal Fibrosis

(2010) Sarah N. Flier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

Fate-determining mechanisms in epithelial–myofibroblast transition: major inhibitory role for Smad3

(2010) András Masszi et al.   JOURNAL OF CELL BIOLOGY

Contribution of Epithelial-derived Fibroblasts to Bleomycin-induced Lung Fibrosis

(2009) Harikrishna Tanjore et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis

(2009) Souhila Medjkane et al.   NATURE CELL BIOLOGY

Role of the actin cytoskeleton in tuning cellular responses to external mechanical stress

(2009) M. B. Asparuhova et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

The role of matrix stiffness in regulating cell behavior

(2008) Rebecca G. Wells   HEPATOLOGY

Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling

(2008) S. Busche et al.   JOURNAL OF CELL SCIENCE

Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells

(2008) Celeste M. Nelson et al.   JOURNAL OF CELLULAR BIOCHEMISTRY