Pathogenesis of Familial Hyperaldosteronism Type II: New Concepts Involving Anion Channels

CLCN2 chloride channel mutations in familial hyperaldosteronism type II

(2018) Ute I. Scholl et al.   NATURE GENETICS

A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism

(2018) Fabio L. Fernandes-Rosa et al.   NATURE GENETICS

Cardiometabolic outcomes and mortality in medically treated primary aldosteronism: a retrospective cohort study

(2018) Gregory L Hundemer et al.   Lancet Diabetes & Endocrinology

Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis

(2018) Silvia Monticone et al.   Lancet Diabetes & Endocrinology

Cellular and Genetic Causes of Idiopathic Hyperaldosteronism

(2018) Kei Omata et al.   HYPERTENSION

Targeted Molecular Characterization of Aldosterone-Producing Adenomas in White Americans

(2018) Kazutaka Nanba et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Unanswered Questions in the Genetic Basis of Primary Aldosteronism

(2017) Ute Scholl   HORMONE AND METABOLIC RESEARCH

Prevalence and Clinical Manifestations of Primary Aldosteronism Encountered in Primary Care Practice

(2017) Silvia Monticone et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

CACNA1HM1549VMutant Calcium Channel Causes Autonomous Aldosterone Production in HAC15 Cells and Is Inhibited by Mibefradil

(2016) Esther N. Reimer et al.   ENDOCRINOLOGY

The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline

(2016) John W. Funder et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

CACNA1H Mutations Are Associated With Different Forms of Primary Aldosteronism

(2016) Georgios Daniil et al.   EBioMedicine

An Update on Familial Hyperaldosteronism

(2015) H. Korah et al.   HORMONE AND METABOLIC RESEARCH

A Meta-Analysis of Somatic KCNJ5 K+Channel Mutations In 1636 Patients With an Aldosterone-Producing Adenoma

(2015) Livia Lenzini et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands

(2015) Koshiro Nishimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism

(2015) Ute I Scholl et al.   eLife

Genetic Spectrum and Clinical Correlates of Somatic Mutations in Aldosterone-Producing Adenoma

(2014) Fabio Luiz Fernandes-Rosa et al.   HYPERTENSION

Cation-chloride cotransporters in neuronal development, plasticity and disease

(2014) Kai Kaila et al.   NATURE REVIEWS NEUROSCIENCE

Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension

(2013) Elena A B Azizan et al.   NATURE GENETICS

Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism

(2013) Ute I Scholl et al.   NATURE GENETICS

Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension

(2013) Felix Beuschlein et al.   NATURE GENETICS

Regulation of ClC-2 gating by intracellular ATP

(2013) Gabriel Stölting et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Potassium Channel Mutant KCNJ5 T158A Expression in HAC-15 Cells Increases Aldosterone Synthesis

(2012) Kenji Oki et al.   ENDOCRINOLOGY

Zona glomerulosa cells of the mouse adrenal cortex are intrinsic electrical oscillators

(2012) Changlong Hu et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5

(2012) U. I. Scholl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KCNJ5 Mutations in European Families With Nonglucocorticoid Remediable Familial Hyperaldosteronism

(2011) Paolo Mulatero et al.   HYPERTENSION

K+ Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension

(2011) M. Choi et al.   SCIENCE

Further study of chromosome 7p22 to identify the molecular basis of familial hyperaldosteronism type II

(2010) K J Carss et al.   JOURNAL OF HUMAN HYPERTENSION

Structure of a Eukaryotic CLC Transporter Defines an Intermediate State in the Transport Cycle

(2010) Liang Feng et al.   SCIENCE

Further evidence for linkage of familial hyperaldosteronism type II at chromosome 7p22 in Italian as well as Australian and South American families

(2009) Norlela Sukor et al.   JOURNAL OF HYPERTENSION

Cardiovascular Outcomes in Patients With Primary Aldosteronism After Treatment

(2008) Cristiana Catena   ARCHIVES OF INTERNAL MEDICINE

EXAMINATION OF CHROMOSOME 7p22 CANDIDATE GENES RBaK, PMS2 AND GNA12 IN FAMILIAL HYPERALDOSTERONISM TYPE II

(2008) YWA Jeske et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

A Novel Form of Human Mendelian Hypertension Featuring Nonglucocorticoid-Remediable Aldosteronism

(2008) David S. Geller et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A New Form of Hereditary Primary Aldosteronism: Familial Hyperaldosteronism Type III

(2008) Paolo Mulatero   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM