Targeted antibiotic discovery through biosynthesis-associated resistance determinants: target directed genome mining

Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria

(2018) Fabian Panter et al.   Chemical Science

The Antibiotic Resistant Target Seeker (ARTS), an exploration engine for antibiotic cluster prioritization and novel drug target discovery

(2017) Mohammad Alanjary et al.   NUCLEIC ACIDS RESEARCH

Dissemination of antibiotic resistance genes from antibiotic producers to pathogens

(2017) Xinglin Jiang et al.   Nature Communications

Resistance Gene-Guided Genome Mining: Serial Promoter Exchanges in Aspergillus nidulans Reveal the Biosynthetic Pathway for Fellutamide B, a Proteasome Inhibitor

(2016) Hsu-Hua Yeh et al.   ACS Chemical Biology

Identification of genes encoding squalestatin S1 biosynthesis and in vitro production of new squalestatin analogues

(2016) B. Bonsch et al.   CHEMICAL COMMUNICATIONS

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Assembly and clustering of natural antibiotics guides target identification

(2016) Chad W Johnston et al.   Nature Chemical Biology

Biosynthetic Pathway of the Reduced Polyketide Product Citreoviridin in Aspergillus terreus var. aureus Revealed by Heterologous Expression in Aspergillus nidulans

(2016) Tzu-Shyang Lin et al.   ORGANIC LETTERS

Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining

(2015) Xiaoyu Tang et al.   ACS Chemical Biology

Self-resistance mechanisms of actinomycetes producing lipid II-targeting antibiotics

(2015) Evi Stegmann et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Escherichia coli  ClbS is a colibactin resistance protein

(2015) Nadège Bossuet-Greif et al.   MOLECULAR MICROBIOLOGY

The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine

(2015) Stéphane Cociancich et al.   Nature Chemical Biology

Characterization of a novel DNA glycosylase fromS. sahachiroiinvolved in the reduction and repair of azinomycin B induced DNA damage

(2015) Shan Wang et al.   NUCLEIC ACIDS RESEARCH

In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly

(2015) Yi-Ling Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides

(2015) Mashal M. Almutairi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting DnaN for tuberculosis therapy using novel griselimycins

(2015) A. Kling et al.   SCIENCE

Ornithine Transcarbamylase ArgK Plays a Dual role for the Self-defense of Phaseolotoxin Producing Pseudomonas syringae pv. phaseolicola

(2015) Li chen et al.   Scientific Reports

Structure-Guided Functional Characterization of Enediyne Self-Sacrifice Resistance Proteins, CalU16 and CalU19

(2014) Sherif I. Elshahawi et al.   ACS Chemical Biology

Cystobactamids: Myxobacterial Topoisomerase Inhibitors Exhibiting Potent Antibacterial Activity

(2014) Sascha Baumann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanisms of Self-Resistance in the Platensimycin- and Platencin-Producing Streptomyces platensis MA7327 and MA7339 Strains

(2014) Ryan M. Peterson et al.   CHEMISTRY & BIOLOGY

The mechanism of negative DNA supercoiling: A cascade of DNA-induced conformational changes prepares gyrase for strand passage

(2014) Airat Gubaev et al.   DNA REPAIR

Penicillin-binding proteins in Actinobacteria

(2014) Hiroshi Ogawara   JOURNAL OF ANTIBIOTICS

Heterologous Expression of the Thiopeptide Antibiotic GE2270 from Planobispora rosea ATCC 53733 in Streptomyces coelicolor Requires Deletion of Ribosomal Genes from the Expression Construct

(2014) Katrin Flinspach et al.   PLoS One

Genetic Basis for the Biosynthesis of the Pharmaceutically Important Class of Epoxyketone Proteasome Inhibitors

(2013) Michelle Schorn et al.   ACS Chemical Biology

Multilocus Sequence Typing Reveals Evidence of Homologous Recombination Linked to Antibiotic Resistance in the Genus Salinispora

(2013) Kelle C. Freel et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Capturing Linear Intermediates and C-Terminal Variants during Maturation of the Thiopeptide GE2270

(2013) Arianna Tocchetti et al.   CHEMISTRY & BIOLOGY

New aminocoumarin antibiotics as gyrase inhibitors

(2013) Lutz Heide   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

The Fish PathogenYersinia ruckeriProduces Holomycin and Uses an RNA Methyltransferase for Self-resistance

(2013) Zhiwei Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Fumagillin Biosynthetic Gene Cluster in Aspergillus fumigatus Encodes a Cryptic Terpene Cyclase Involved in the Formation of β-trans-Bergamotene

(2013) Hsiao-Ching Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ribosome-targeting antibiotics and mechanisms of bacterial resistance

(2013) Daniel N. Wilson   NATURE REVIEWS MICROBIOLOGY

Meleagrin, a New FabI Inhibitor from Penicillium chryosogenum with at Least One Additional Mode of Action

(2013) Chang Ji Zheng et al.   PLoS One

Deregulation of translation due to post-transcriptional modification of rRNA explains why erm genes are inducible

(2013) Pulkit Gupta et al.   Nature Communications

The Genome of Tolypocladium inflatum: Evolution, Organization, and Expression of the Cyclosporin Biosynthetic Gene Cluster

(2013) Kathryn E. Bushley et al.   PLoS Genetics

Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites

(2013) James S. Pham et al.   International Journal for Parasitology-Drugs and Drug Resistance

Biosynthesis of Albomycin δ2 Provides a Template for Assembling Siderophore and Aminoacyl-tRNA Synthetase Inhibitor Conjugates

(2012) Yu Zeng et al.   ACS Chemical Biology

Self-Resistance to an Antitumor Antibiotic: A DNA Glycosylase Triggers the Base-Excision Repair System in Yatakemycin Biosynthesis

(2012) Hui Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin

(2012) Dominic Hoepfner et al.   Cell Host & Microbe

Molecular Mechanisms of Acquired Proteasome Inhibitor Resistance

(2012) Andrew J. Kale et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of Yatakemycin Gene Cluster Revealing a Radical S-Adenosylmethionine Dependent Methyltransferase and Highlighting Spirocyclopropane Biosynthesis

(2012) Wei Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aminoacyl tRNA synthetases as targets for antibiotic development

(2012) Vinayak Agarwal et al.   MedChemComm

De novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformans

(2012) Carl A. Morrow et al.   PLoS Pathogens

Bacterial Self-Resistance to the Natural Proteasome Inhibitor Salinosporamide A

(2011) Andrew J. Kale et al.   ACS Chemical Biology

Pentapeptide-repeat proteins that act as topoisomerase poison resistance factors have a common dimer interface

(2011) Matthew W. Vetting et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Molecular Basis for Mycophenolic Acid Biosynthesis in Penicillium brevicompactum

(2011) Torsten Bak Regueira et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A new class of IMP dehydrogenase with a role in self-resistance of mycophenolic acid producing fungi

(2011) Bjarne G Hansen et al.   BMC MICROBIOLOGY

Molecular mechanisms of antibiotic resistance

(2011) Gerard D. Wright   CHEMICAL COMMUNICATIONS

Borrelidin, a potent antimalarial: stage-specific inhibition profile of synchronized cultures of Plasmodium falciparum

(2011) Aki Ishiyama et al.   JOURNAL OF ANTIBIOTICS

Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin in Streptomyces lydicus: Tailoring Modification of 3-Methyl-Aspartate

(2011) D. H. Horna et al.   JOURNAL OF BACTERIOLOGY

Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

(2011) M. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis

(2011) M. J. Smanski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the thiazolyl peptide GE37468 gene cluster fromStreptomycesATCC 55365 and heterologous expression inStreptomyces lividans

(2011) Travis S. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chitin stimulates production of the antibiotic andrimid in a Vibrio coralliilyticus strain

(2011) Matthias Wietz et al.   Environmental Microbiology Reports

Involvement of the Beta Subunit of RNA Polymerase in Resistance to Streptolydigin and Streptovaricin in the Producer Organisms Streptomyces lydicus and Streptomyces spectabilis

(2010) M. Sanchez-Hidalgo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activation of a Silent Fungal Polyketide Biosynthesis Pathway through Regulatory Cross Talk with a Cryptic Nonribosomal Peptide Synthetase Gene Cluster

(2010) S. Bergmann et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The Kalimantacin/Batumin Biosynthesis Operon Encodes a Self-Resistance Isoform of the FabI Bacterial Target

(2010) Wesley Mattheus et al.   CHEMISTRY & BIOLOGY

Isolation and Purification of a New Kalimantacin/Batumin-Related Polyketide Antibiotic and Elucidation of Its Biosynthesis Gene Cluster

(2010) Wesley Mattheus et al.   CHEMISTRY & BIOLOGY

MccE Provides Resistance to Protein Synthesis Inhibitor Microcin C by Acetylating the Processed Form of the Antibiotic

(2010) Maria Novikova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional and Kinetic Analysis of the Phosphotransferase CapP Conferring Selective Self-resistance to Capuramycin Antibiotics

(2010) Zhaoyong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antibacterial Compounds from Marine Vibrionaceae Isolated on a Global Expedition

(2010) Matthias Wietz et al.   Marine Drugs

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

IMP Dehydrogenase: Structure, Mechanism, and Inhibition

(2009) Lizbeth Hedstrom   CHEMICAL REVIEWS

Efflux-Mediated Drug Resistance in Bacteria

(2009) Xian-Zhi Li et al.   DRUGS

The kirromycin gene cluster of Streptomyces collinus Tü 365 codes for an aspartate-α-decarboxylase, KirD, which is involved in the biosynthesis of the precursor β-alanine

(2009) Kristina J Laiple et al.   JOURNAL OF ANTIBIOTICS

Genome Sequences of Three Agrobacterium Biovars Help Elucidate the Evolution of Multichromosome Genomes in Bacteria

(2009) S. C. Slater et al.   JOURNAL OF BACTERIOLOGY

Ribosomally Synthesized Thiopeptide Antibiotics Targeting Elongation Factor Tu

(2009) Rowan P. Morris et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vitro Activity of Mupirocin on Clinical Isolates ofStaphylococcus aureusand its Potential Implications in Chronic Rhinosinusitis

(2009) Kien R. Ha et al.   LARYNGOSCOPE

The aminocoumarins: biosynthesis and biology

(2009) Lutz Heide   NATURAL PRODUCT REPORTS

Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens

(2009) Sophie Brinster et al.   NATURE

Molecular mechanisms of proteasome assembly

(2009) Shigeo Murata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin

(2009) Laura C. Wieland Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

(2009) A. S. Eustaquio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nisin biotechnological production and application: a review

(2009) Luciana Juncioni de Arauz et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Characterization of the Azinomycin B Biosynthetic Gene Cluster Revealing a Different Iterative Type I Polyketide Synthase for Naphthoate Biosynthesis

(2008) Qunfei Zhao et al.   CHEMISTRY & BIOLOGY

Platensimycin: A Promising Antimicrobial Targeting Fatty Acid Synthesis

(2008) D. Manallack et al.   CURRENT MEDICINAL CHEMISTRY

Aurovertins F–H from the Entomopathogenic FungusMetarhizium anisopliae(1)

(2008) Miwa Azumi et al.   JOURNAL OF NATURAL PRODUCTS

How Bacteria Consume Their Own Exoskeletons (Turnover and Recycling of Cell Wall Peptidoglycan)

(2008) J. T. Park et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Translational Regulation via L11: Molecular Switches on the Ribosome Turned On and Off by Thiostrepton and Micrococcin

(2008) Joerg M. Harms et al.   MOLECULAR CELL

Investigations of valanimycin biosynthesis: Elucidation of the role of seryl-tRNA

(2008) R. P. Garg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Andrimid producers encode an acetyl-CoA carboxyltransferase subunit resistant to the action of the antibiotic

(2008) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA