The δ‐opioid receptor positive allosteric modulator BMS 986187 is a G‐protein‐biased allosteric agonist

Role of signalling molecules in behaviours mediated by the δ opioid receptor agonist SNC80

(2018) Isaac J Dripps et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor

(2018) Tao Che et al.   CELL

PI3K class II α regulates δ-opioid receptor export from the trans-Golgi network

(2017) Daniel J. Shiwarski et al.   MOLECULAR BIOLOGY OF THE CELL

A Scale of Agonism and Allosteric Modulation for Assessment of Selectivity, Bias, and Receptor Mutation

(2017) Terry Kenakin   MOLECULAR PHARMACOLOGY

Sequence-Specific Regulation of Endocytic Lifetimes Modulates Arrestin-Mediated Signaling at the µ Opioid Receptor

(2017) Zara Y. Weinberg et al.   MOLECULAR PHARMACOLOGY

Pharmacologic Evidence for a Putative Conserved Allosteric Site on Opioid Receptors

(2017) Kathryn E. Livingston et al.   MOLECULAR PHARMACOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Delta opioid receptors expressed in forebrain GABAergic neurons are responsible for SNC80-induced seizures

(2015) Paul Chu Sin Chung et al.   BEHAVIOURAL BRAIN RESEARCH

β-Arrestin 2 dependence of δ opioid receptor agonists is correlated with alcohol intake

(2015) T Chiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Discovery, Synthesis, and Molecular Pharmacology of Selective Positive Allosteric Modulators of the δ-Opioid Receptor

(2015) Neil T. Burford et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking

(2014) E W Ong et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identifying ligand-specific signalling within biased responses: focus on δ opioid receptor ligands

(2014) I Charfi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Positive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medications

(2014) N T Burford et al.   BRITISH JOURNAL OF PHARMACOLOGY

Disruption of the Na+ion binding site as a mechanism for positive allosteric modulation of the mu-opioid receptor

(2014) Kathryn E. Livingston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Epidemiology of Depression Across Cultures

(2013) Ronald C. Kessler et al.   Annual Review of Public Health

Efficacy and ligand bias at the μ-opioid receptor

(2013) E Kelly   BRITISH JOURNAL OF PHARMACOLOGY

Ligand- and cell-dependent determinants of internalization and cAMP modulation by delta opioid receptor (DOR) agonists

(2013) Iness Charfi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Signalling bias in new drug discovery: detection, quantification and therapeutic impact

(2013) Terry Kenakin et al.   NATURE REVIEWS DRUG DISCOVERY

A Versatile Toolkit to Produce Sensitive FRET Biosensors to Visualize Signaling in Time and Space

(2013) R. D. Fritz et al.   Science Signaling

Ligand-directed signalling within the opioid receptor family

(2012) Amynah A Pradhan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antidepressant-like Effects of δ Opioid Receptor Agonists in Animal Models

(2012) Akiyoshi Saitoh et al.   Current Neuropharmacology

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

(2012) W. Liu et al.   SCIENCE

Opioid receptors: distinct roles in mood disorders

(2012) Pierre-Eric Lutz et al.   TRENDS IN NEUROSCIENCES

A Simple Method for Quantifying Functional Selectivity and Agonist Bias

(2011) Terry Kenakin et al.   ACS Chemical Neuroscience

The delta opioid receptor: an evolving target for the treatment of brain disorders

(2011) Amynah A. Pradhan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identification of Orthosteric and Allosteric Site Mutations in M2Muscarinic Acetylcholine Receptors That Contribute to Ligand-selective Signaling Bias

(2010) Karen J. Gregory et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand-Directed Trafficking of the  -Opioid Receptor In Vivo: Two Paths Toward Analgesic Tolerance

(2010) A. A. A. Pradhan et al.   JOURNAL OF NEUROSCIENCE

Allosteric modulation of G protein-coupled receptors: A pharmacological perspective

(2010) Peter Keov et al.   NEUROPHARMACOLOGY

Therapeutic potential of β-arrestin- and G protein-biased agonists

(2010) Erin J. Whalen et al.   TRENDS IN MOLECULAR MEDICINE

G Protein independent phosphorylation and internalization of the δ-opioid receptor

(2009) Faye A. Bradbury et al.   JOURNAL OF NEUROCHEMISTRY

In Vivo Delta Opioid Receptor Internalization Controls Behavioral Effects of Agonists

(2009) Amynah A. A. Pradhan et al.   PLoS One

Bioluminescence Resonance Energy Transfer Assays Reveal Ligand-specific Conformational Changes within Preformed Signaling Complexes Containing δ-Opioid Receptors and Heterotrimeric G Proteins

(2008) Nicolas Audet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

Distinct conformational changes in  -arrestin report biased agonism at seven-transmembrane receptors

(2008) A. K. Shukla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA