A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension

Bone Morphogenetic Protein 9 is a Mechanistic Biomarker of Portopulmonary Hypertension

(2018) Ivana Nikolic et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin

(2017) Sophie Le Gonidec et al.   FASEB JOURNAL

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Structure–activity relationship of novel macrocyclic biased apelin receptor agonists

(2017) Alexandre Murza et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Load-dependent effects of apelin on murine cardiomyocytes

(2017) Rémi Peyronnet et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Structural Basis for Apelin Control of the Human Apelin Receptor

(2017) Yingli Ma et al.   STRUCTURE

Microarray Analysis and Detection of MicroRNAs Associated with Chronic Thromboembolic Pulmonary Hypertension

(2017) Ran Miao et al.   Biomed Research International

[Pyr1]Apelin-13(1–12) Is a Biologically Active ACE2 Metabolite of the Endogenous Cardiovascular Peptide [Pyr1]Apelin-13

(2017) Peiran Yang et al.   Frontiers in Neuroscience

A Systematic Approach to Identify Biased Agonists of the Apelin Receptor through High-Throughput Screening

(2017) Danielle McAnally et al.   SLAS Discovery

Cardiac action of the first G protein biased small molecule apelin agonist

(2016) Cai Read et al.   BIOCHEMICAL PHARMACOLOGY

The Metalloprotease Neprilysin Degrades and Inactivates Apelin Peptides

(2016) Shaun M. K. McKinnie et al.   CHEMBIOCHEM

Structure-based discovery of opioid analgesics with reduced side effects

(2016) Aashish Manglik et al.   NATURE

A randomized, phase 2 study investigating TRV130, a biased ligand of the μ-opioid receptor, for the intravenous treatment of acute pain

(2016) Eugene R. Viscusi et al.   PAIN

Suppression of endothelial CD39/ENTPD1 is associated with pulmonary vascular remodeling in pulmonary arterial hypertension

(2015) Mikko H. Helenius et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Estradiol improves right ventricular function in rats with severe angioproliferative pulmonary hypertension: effects of endogenous and exogenous sex hormones

(2015) Andrea L. Frump et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Elafin Reverses Pulmonary Hypertension via Caveolin-1–Dependent Bone Morphogenetic Protein Signaling

(2015) Nils P. Nickel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects

(2015) Rajiv D. Machado et al.   HUMAN MUTATION

Design, Characterization, and First-In-Human Study of the Vascular Actions of a Novel Biased Apelin Receptor Agonist

(2015) A. L. Brame et al.   HYPERTENSION

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

(2015) Lu Long et al.   NATURE MEDICINE

Targeting BMP signalling in cardiovascular disease and anaemia

(2015) Nicholas W. Morrell et al.   Nature Reviews Cardiology

Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system

(2015) Peiran Yang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Stability and degradation patterns of chemically modified analogs of apelin-13 in plasma and cerebrospinal fluid

(2014) Alexandre Murza et al.   BIOPOLYMERS

ERG-APLNR Axis Controls Pulmonary Venule Endothelial Proliferation in Pulmonary Veno-Occlusive Disease

(2014) Christopher Lathen et al.   CIRCULATION

Biased Signaling Favoring Giover β-Arrestin Promoted by an Apelin Fragment Lacking the C-terminal Phenylalanine

(2014) Emilie Ceraudo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension

(2014) Thomas Bertero et al.   JOURNAL OF CLINICAL INVESTIGATION

Apelin-13 stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in myocardial microvascular endothelial cells

(2014) XIAOMAN YANG et al.   Molecular Medicine Reports

Apelin Increases Cardiac Contractility via Protein Kinase Cε- and Extracellular Signal-Regulated Kinase-Dependent Mechanisms

(2014) Ábel Perjés et al.   PLoS One

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension

(2013) Edda Spiekerkoetter et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular pathogenesis of pulmonary arterial hypertension

(2012) Marlene Rabinovitch   JOURNAL OF CLINICAL INVESTIGATION

APJ acts as a dual receptor in cardiac hypertrophy

(2012) Maria Cecilia Scimia et al.   NATURE

An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension

(2012) Jongmin Kim et al.   NATURE MEDICINE

Molecular Signature of a Right Heart Failure Program in Chronic Severe Pulmonary Hypertension

(2011) Jennifer I. Drake et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Disruption of the Apelin-APJ System Worsens Hypoxia-Induced Pulmonary Hypertension

(2011) Suparna M. Chandra et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Disruption of PPARγ/β-catenin–mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival

(2011) Tero-Pekka Alastalo et al.   JOURNAL OF CLINICAL INVESTIGATION

Apelin and Pulmonary Hypertension

(2011) Charlotte U. Andersen et al.   Pulmonary Circulation

Antioxidant treatment attenuates pulmonary arterial hypertension-induced heart failure

(2010) Everaldo M. Redout et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Exploring the ‘RPRL’ Motif of Apelin-13 through Molecular Simulation and Biological Evaluation of Cyclic Peptide Analogues

(2010) N. J. Maximilian Macaluso et al.   ChemMedChem

PRX-08066, a Novel 5-Hydroxytryptamine Receptor 2B Antagonist, Reduces Monocrotaline-Induced Pulmonary Arterial Hypertension and Right Ventricular Hypertrophy in Rats

(2010) S. L. Porvasnik et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

International Union of Basic and Clinical Pharmacology. LXXIV. Apelin Receptor Nomenclature, Distribution, Pharmacology, and Function

(2010) S. L. Pitkin et al.   PHARMACOLOGICAL REVIEWS

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Design and validation of Segment - freely available software for cardiovascular image analysis

(2010) Einar Heiberg et al.   BMC MEDICAL IMAGING

Endogenous regulation of cardiovascular function by apelin-APJ

(2009) David N. Charo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Apelin decreases myocardial injury and improves right ventricular function in monocrotaline-induced pulmonary hypertension

(2009) Inês Falcão-Pires et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure

(2009) Kurt R. Stenmark et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Pulmonary Vascular Remodeling Correlates with Lung Eggs and Cytokines in Murine Schistosomiasis

(2009) Alexi Crosby et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

[Pyr 1 ]Apelin-13 Identified as the Predominant Apelin Isoform in the Human Heart

(2009) Janet J. Maguire et al.   HYPERTENSION

Pulmonary apelin levels and effects in rats with hypoxic pulmonary hypertension

(2009) C.U. Andersen et al.   RESPIRATORY MEDICINE