Discovery and characterization of a novel C-terminal peptide carboxyl methyltransferase in a lassomycin-like lasso peptide biosynthetic pathway

Biosynthetic Gene Cluster of a D-Tryptophan-Containing Lasso Peptide, MS-271

(2018) Zhi Feng et al.   CHEMBIOCHEM

Albusnodin: an acetylated lasso peptide from Streptomyces albus

(2018) Chuhan Zong et al.   CHEMICAL COMMUNICATIONS

Expedient on-resin modification of a peptide C-terminus through a benzotriazole linker

(2018) Anand Selvaraj et al.   Chemical Science

An orthogonal system for heterologous expression of actinobacterial lasso peptides in Streptomyces hosts

(2018) Jimmy Mevaere et al.   Scientific Reports

Molecular Basis for Autocatalytic Backbone N-Methylation in RiPP Natural Product Biosynthesis

(2018) Chayanid Ongpipattanakul et al.   ACS Chemical Biology

Reconstitution and Substrate Specificity of the Radical S-Adenosyl-methionine Thiazole C-Methyltransferase in Thiomuracin Biosynthesis

(2017) Nilkamal Mahanta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism of a Class C Radical S-Adenosyl-l-methionine Thiazole Methyl Transferase

(2017) Zhengan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A new genome-mining tool redefines the lasso peptide biosynthetic landscape

(2017) Jonathan I Tietz et al.   Nature Chemical Biology

Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products

(2017) Niels S van der Velden et al.   Nature Chemical Biology

Post-translational modifications involved in the biosynthesis of thiopeptide antibiotics

(2017) Qingfei Zheng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Mechanistic insights into class B radical-S-adenosylmethionine methylases: ubiquitous tailoring enzymes in natural product biosynthesis

(2016) Shanshan Zhou et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Dual substrate-controlled kinase activity leads to polyphosphorylated lasso peptides

(2016) Shaozhou Zhu et al.   FEBS LETTERS

Insights into the Unique Phosphorylation of the Lasso Peptide Paeninodin

(2016) Shaozhou Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

The B12-Radical SAM Enzyme PoyC Catalyzes Valine Cβ-Methylation during Polytheonamide Biosynthesis

(2016) Aubérie Parent et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total chemical synthesis of lassomycin and lassomycin-amide

(2016) S. Lear et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Versatile Peptide C-Terminal Functionalization via a Computationally Engineered Peptide Amidase

(2016) Bian Wu et al.   ACS Catalysis

Structure-Activity Analysis of Gram-positive Bacterium-producing Lasso Peptides with Anti-mycobacterial Activity

(2016) Junji Inokoshi et al.   Scientific Reports

The B1 Protein Guides the Biosynthesis of a Lasso Peptide

(2016) Shaozhou Zhu et al.   Scientific Reports

Lasso Peptides: An Intriguing Class of Bacterial Natural Products

(2015) Julian D. Hegemann et al.   ACCOUNTS OF CHEMICAL RESEARCH

Characterization of Sviceucin from Streptomyces Provides Insight into Enzyme Exchangeability and Disulfide Bond Formation in Lasso Peptides

(2015) Yanyan Li et al.   ACS Chemical Biology

A New Golden Age of Natural Products Drug Discovery

(2015) Ben Shen   CELL

Expanding the chemical diversity of lasso peptide MccJ25 with genetically encoded noncanonical amino acids

(2015) Frank J. Piscotta et al.   CHEMICAL COMMUNICATIONS

Structure, Bioactivity, and Resistance Mechanism of Streptomonomicin, an Unusual Lasso Peptide from an Understudied Halophilic Actinomycete

(2015) Mikhail Metelev et al.   CHEMISTRY & BIOLOGY

Anti-tuberculosis lead molecules from natural products targeting Mycobacterium tuberculosis ClpC1

(2015) Hanki Lee et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Chaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama Desert

(2015) Somayah S. Elsayed et al.   JOURNAL OF ORGANIC CHEMISTRY

A prevalent peptide-binding domain guides ribosomal natural product biosynthesis

(2015) Brandon J Burkhart et al.   Nature Chemical Biology

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Xanthomonins I-III: A New Class of Lasso Peptides with a Seven-Residue Macrolactam Ring

(2014) Julian D. Hegemann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in anaerobic bacteria

(2014) Anne-Catrin Letzel et al.   BMC GENOMICS

Targeting Mycobacterial Proteolytic Complexes with Natural Products

(2014) Tanya Parish   CHEMISTRY & BIOLOGY

Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2

(2014) Ekaterina Gavrish et al.   CHEMISTRY & BIOLOGY

Lasso peptides from proteobacteria: Genome mining employing heterologous expression and mass spectrometry

(2013) Julian D. Hegemann et al.   BIOPOLYMERS

The Astexin-1 Lasso Peptides: Biosynthesis, Stability, and Structural Studies

(2013) Marcel Zimmermann et al.   CHEMISTRY & BIOLOGY

Prospecting genomes for lasso peptides

(2013) Mikhail O. Maksimov et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Molecular cloning of the gene cluster for lariatin biosynthesis of Rhodococcus jostii K01-B0171

(2012) Junji Inokoshi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Catalytic promiscuity of a bacterial α-N-methyltransferase

(2012) Qi Zhang et al.   FEBS LETTERS

Caulosegnins I–III: A Highly Diverse Group of Lasso Peptides Derived from a Single Biosynthetic Gene Cluster

(2012) Julian D. Hegemann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lasso peptides: structure, function, biosynthesis, and engineering

(2012) Mikhail O. Maksimov et al.   NATURAL PRODUCT REPORTS

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

Precursor-centric genome-mining approach for lasso peptide discovery

(2012) M. O. Maksimov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural characterization of the mitomycin 7-O-methyltransferase

(2011) Shanteri Singh et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Genome mining for ribosomally synthesized natural products

(2010) Juan E Velásquez et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Strategies for the Discovery of New Natural Products by Genome Mining

(2009) Malek Zerikly et al.   CHEMBIOCHEM

New natural product biosynthetic chemistry discovered by genome mining

(2009) Christophe Corre et al.   NATURAL PRODUCT REPORTS

Follow the leader: the use of leader peptides to guide natural product biosynthesis

(2009) Trent J Oman et al.   Nature Chemical Biology

Genome Mining for Novel Natural Product Discovery

(2008) Gregory L. Challis   JOURNAL OF MEDICINAL CHEMISTRY

Isolation and Structural Characterization of Capistruin, a Lasso Peptide Predicted from the Genome Sequence of Burkholderia thailandensis E264

(2008) Thomas A. Knappe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY