Regio- and Enantioselective Iridium-Catalyzed N-Allylation of Indoles and Related Azoles with Racemic Branched Alkyl-Substituted Allylic Acetates

Catalytic nucleophilic ‘umpoled’ π-allyl reagents

(2018) Kim Spielmann et al.   CHEMICAL SOCIETY REVIEWS

Access to 3-Oxindoles from Allylic Alcohols and Indoles

(2018) Hortense Lauwick et al.   CHEMISTRY-A EUROPEAN JOURNAL

Amphiphilic π-Allyliridium C,O-Benzoates Enable Regio- and Enantioselective Amination of Branched Allylic Acetates Bearing Linear Alkyl Groups

(2018) Arismel Tena Meza et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Asymmetric Nitrogen-Selective Addition Reaction of Indoles to Alkoxyallenes

(2018) Seok Hyeon Jang et al.   ORGANIC LETTERS

Regio- and Enantioselective Iridium-Catalyzed Amination of Racemic Branched Alkyl-Substituted Allylic Acetates with Primary and Secondary Aromatic and Heteroaromatic Amines

(2018) Seung Wook Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Study of Intermediates in Iridium–(Phosphoramidite,Olefin)-Catalyzed Enantioselective Allylic Substitution

(2017) Simon L. Rössler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd-Catalyzed Hydroamination of Alkoxyallenes with Azole Heterocycles: Examples and Mechanistic Proposal

(2017) Ivan Bernar et al.   ORGANIC LETTERS

Enantioselective Iridium-Catalyzed Allylic Cyclizations

(2017) Michael A. Schafroth et al.   ORGANIC LETTERS

An Iridium(I) N-Heterocyclic Carbene Complex Catalyzes Asymmetric Intramolecular Allylic Amination Reactions

(2016) Ke-Yin Ye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models

(2016) H. M. Weir et al.   CANCER RESEARCH

Catalytic asymmetric dearomatization (CADA) reactions of phenol and aniline derivatives

(2016) Wen-Ting Wu et al.   CHEMICAL SOCIETY REVIEWS

Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas

(2016) Rishi G. Vaswani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Iridium-Catalyzed Asymmetric Allylic Amination Reactions with N-Aryl Phosphoramidite Ligands

(2016) Xiao Zhang et al.   ORGANOMETALLICS

Discovery, design, and synthesis of indole-based EZH2 inhibitors

(2015) Victor S. Gehling et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Iridium-Catalyzed Intramolecular Asymmetric Allylic Dearomatization Reaction of Pyridines, Pyrazines, Quinolines, and Isoquinolines

(2015) Ze-Peng Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Direct Functionalization of Indoles by Pd/Sulfoxide-Phosphine-Catalyzed N-Allylic Alkylation

(2015) Li-Yan Chen et al.   ORGANIC LETTERS

Metal catalyzed allylic alkylation: its development in the Trost laboratories

(2015) Barry M. Trost   TETRAHEDRON

Asymmetric synthesis of N-allylic indoles via regio- and enantioselective allylation of aryl hydrazines

(2015) Kun Xu et al.   Nature Communications

Direct Asymmetric Dearomatization of Pyridines and Pyrazines by Iridium-Catalyzed Allylic Amination Reactions

(2014) Ze-Peng Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective CH Functionalization of Alcohols by Redox-Triggered Carbonyl Addition: Borrowing Hydrogen, Returning Carbon

(2014) John M. Ketcham et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Regio- and Enantioselective Synthesis of N-Substituted 2-Pyridones: Iridium-Catalyzed Intermolecular Asymmetric Allylic Amination

(2014) Xiao Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regio- and Enantioselective Synthesis ofN-Allylindoles by Iridium-Catalyzed Allylic Amination/Transition-Metal-Catalyzed Cyclization Reactions

(2014) Ke-Yin Ye et al.   CHEMISTRY-A EUROPEAN JOURNAL

Rings in Drugs

(2014) Richard D. Taylor et al.   JOURNAL OF MEDICINAL CHEMISTRY

Iridium-Catalyzed C-3 Allylation of Indoles with Allylic Alcohols Promoted by a Brønsted Acid

(2014) Chun Cai et al.   SYNTHESIS-STUTTGART

Pd-Catalyzed Asymmetric Allylic Alkylations of 3-Substituted Indoles Using Chiral P/Olefin Ligands

(2013) Yilin Liu et al.   ORGANIC LETTERS

Highly Regioselective Allylic Substitution Reactions Catalyzed by an Air-Stable (π-Allyl)iridium Complex Derived from Dinaphthocyclooctatetraene and a Phosphoramidite Ligand

(2013) Shu-Li You et al.   SYNTHESIS-STUTTGART

Direct, Enantioselective Iridium-Catalyzed Allylic Amination of Racemic Allylic Alcohols

(2012) Marc Lafrance et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

AsymmetricN-Allylation of Indoles Through the Iridium-Catalyzed Allylic Alkylation/Oxidation of Indolines

(2012) Wen-Bo Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Dearomatization Reactions

(2012) Chun-Xiang Zhuo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective synthesis of 2,5-dihydrobenzo[b]azepine derivatives via iridium-catalyzed asymmetric allylic amination with 2-allylanilines and ring-closing-metathesis reaction

(2012) Ke-Yin Ye et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enhanced anti-Diastereo- and Enantioselectivity in Alcohol-Mediated Carbonyl Crotylation Using an Isolable Single Component Iridium Catalyst

(2011) Xin Gao et al.   JOURNAL OF ORGANIC CHEMISTRY

Chemo- and Regioselectivity-Tunable Pd-Catalyzed Allylic Alkylation of Imines

(2011) Jian-Ping Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Iridium-Catalyzed Allylic Substitutions with Hydroxamic Acid Derivatives as N-Nucleophiles

(2011) Martin Gärtner et al.   ORGANIC LETTERS

Highly Enantioselective Pd-Catalyzed Allylic Alkylation of Indoles Using Sulfur-MOP Ligand

(2011) Takashi Hoshi et al.   ORGANIC LETTERS

Mechanistically Driven Development of Iridium Catalysts for Asymmetric Allylic Substitution

(2010) John F. Hartwig et al.   ACCOUNTS OF CHEMICAL RESEARCH

Ruthenium(IV) Complexes Featuring P,O-Chelating Ligands: Regioselective Substitution Directly from Allylic Alcohols

(2010) Basker Sundararaju et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pd-Catalyzed Enantioselective Allyl−Allyl Cross-Coupling

(2010) Ping Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereospecific Substitution of Allylic Alcohols To Give Optically Active Primary Allylic Amines: Unique Reactivity of a (P,alkene)Ir Complex Modulated by Iodide

(2010) Markus Roggen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Dynamic Kinetic Asymmetric Transformations of Vinyl Aziridines with Nitrogen Heterocycles: Rapid Access to Biologically Active Pyrroles and Indoles

(2010) Barry M. Trost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic asymmetric allylic alkylation employing heteroatom nucleophiles: a powerful method for C–X bond formation

(2010) Barry M. Trost et al.   Chemical Science

Iridium-Catalyzed Regio- and Enantioselective N-Allylation of Indoles

(2009) Levi M. Stanley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct, ChemoselectiveN-tert-Prenylation of Indoles by CH Functionalization

(2009) Michael R. Luzung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective iridium-catalyzed carbonyl allylation from the alcohol oxidation level via transfer hydrogenation: minimizing pre-activation for synthetic efficiency

(2009) Soo Bong Han et al.   CHEMICAL COMMUNICATIONS

Ir-Catalyzed Asymmetric Allylic Substitutions with (Phosphoramidite)Ir Complexes-Resting States, Synthesis, and Characterization of Catalytically Active (π-Allyl)Ir Complexes

(2009) Stephanie Spiess et al.   CHEMISTRY-A EUROPEAN JOURNAL

Iridium-Catalyzed Enantioselective Allylic Alkylation using Chiral Phosphoramidite Ligand Bearing an Amide Moiety

(2008) Gen Onodera et al.   ADVANCED SYNTHESIS & CATALYSIS

Fast and Highly Regioselective Allylation of Indole and Pyrrole Compounds by Allyl Alcohols Using Ru-Sulfonate Catalysts

(2008) Alexey B. Zaitsev et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed β-Allylation of 2,3-Disubstituted Indoles

(2008) Natsuko Kagawa et al.   ORGANIC LETTERS

Ir-Catalyzed Regio- and Enantioselective Friedel–Crafts-Type Allylic Alkylation of Indoles

(2008) Wen-Bo Liu et al.   ORGANIC LETTERS

Allylation ofN-Heterocycles with Allylic Alcohols Employing Self-Assembling Palladium Phosphane Catalysts

(2008) Ippei Usui et al.   ORGANIC LETTERS