Catalytic Enantioselective CH Functionalization of Alcohols by Redox-Triggered Carbonyl Addition: Borrowing Hydrogen, Returning Carbon

Catalysis-Based Total Synthesis of Putative Mandelalide A

(2014) Jens Willwacher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Redox-Triggered CC Coupling of Diols and Alkynes: Synthesis of β,γ-Unsaturated α-Hydroxyketones and Furans by Ruthenium-Catalyzed Hydrohydroxyalkylation

(2014) Emma L. McInturff et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Redox-Triggered C–C Coupling of Alcohols and Vinyl Epoxides: Diastereo- and Enantioselective Formation of All-Carbon Quaternary Centers via tert-(Hydroxy)-Prenylation

(2014) Jiajie Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polyketide construction via hydrohydroxyalkylation and related alcohol C–H functionalizations: reinventing the chemistry of carbonyl addition

(2014) Anne-Marie R. Dechert-Schmitt et al.   NATURAL PRODUCT REPORTS

Protecting-Group-Free Diastereoselective CC Coupling of 1,3-Glycols and Allyl Acetate through Site-Selective Primary Alcohol Dehydrogenation

(2013) Anne-Marie R. Dechert-Schmitt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regio- and Diastereoselective CC Coupling of α-Olefins and Styrenes to 3-Hydroxy-2-oxindoles by Ru-Catalyzed Hydrohydroxyalkylation

(2013) Eiji Yamaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Cyanolide A in the Absence of Protecting Groups, Chiral Auxiliaries, or Premetalated Carbon Nucleophiles

(2013) Andrew R. Waldeck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis of (+)-trans-Aerangis Lactone

(2013) Aejin Kim et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Modular Total Synthesis of Rhizopodin: A Highly Potent G-Actin Dimerizing Macrolide

(2013) Manuel Kretschmer  et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis of 6-Deoxyerythronolide B via C–C Bond-Forming Transfer Hydrogenation

(2013) Xin Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ruthenium-Catalyzed Hydrohydroxyalkylation of Acrylates with Diols and α-Hydroxycarbonyl Compounds To Form Spiro- and α-Methylene-γ-butyrolactones

(2013) Emma L. McInturff et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (+)-Trienomycins A and F via C–C Bond-Forming Hydrogenation and Transfer Hydrogenation

(2013) David J. Del Valle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Successive C–C Coupling of Dienes to Vicinally Dioxygenated Hydrocarbons: Ruthenium Catalyzed [4 + 2] Cycloaddition across the Diol, Hydroxycarbonyl, or Dione Oxidation Levels

(2013) Laina M. Geary et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ruthenium Catalyzed Hydrohydroxyalkylation of Isoprene with Heteroaromatic Secondary Alcohols: Isolation and Reversible Formation of the Putative Metallacycle Intermediate

(2013) Boyoung Y. Park et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoselective Synthesis of the Butyrolactone and the Oxazoline/Furan Fragment of Leupyrrin A1

(2013) Thomas Debnar et al.   ORGANIC LETTERS

Regioselective Ruthenium Catalyzed Hydrohydroxyalkylation of Dienes with 3-Hydroxy-2-oxindoles: Prenylation, Geranylation, and Beyond

(2013) Te-Yu Chen et al.   ORGANIC LETTERS

Stereoselective synthesis of the C1–C8 subunit of peloruside A

(2013) Sadagopan Raghavan et al.   TETRAHEDRON

Enantioselective synthesis of (+)-aspercyclide A

(2013) Jimmy J.P. Sejberg et al.   TETRAHEDRON LETTERS

Diastereo- and Enantioselective Iridium-Catalyzed Carbonyl Propargylation from the Alcohol or Aldehyde Oxidation Level: 1,3-Enynes as Allenylmetal Equivalents

(2012) Laina M. Geary et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient, divergent synthesis of cryptophycin unit A analogues

(2012) Kyle L. Bolduc et al.   CHEMICAL COMMUNICATIONS

Concise Synthesis of the Macrocyclic Core of Rhizopodin by a Heck Macrocyclization Strategy

(2012) Michael Dieckmann et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Conversion of Primary Alcohols to α-exo-Methylene γ-Butyrolactones via Iridium-Catalyzed C–C Bond-Forming Transfer Hydrogenation: 2-(Alkoxycarbonyl)allylation

(2012) T. Patrick Montgomery et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Studies toward the Unique Pederin Family Member Psymberin: Full Structure Elucidation, Two Alternative Total Syntheses, and Analogs

(2012) Yu Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chiral-Anion-Dependent Inversion of Diastereo- and Enantioselectivity in Carbonyl Crotylation via Ruthenium-Catalyzed Butadiene Hydrohydroxyalkylation

(2012) Emma L. McInturff et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct, Redox-Neutral Prenylation and Geranylation of Secondary Carbinol C–H Bonds: C4-Regioselectivity in Ruthenium-Catalyzed C–C Couplings of Dienes to α-Hydroxy Esters

(2012) Joyce C. Leung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoselective Synthesis of the Macrolactone Core of (+)-Neopeltolide

(2012) Sadagopan Raghavan et al.   ORGANIC LETTERS

Iridium-Catalyzed Allylation of Chiral β-Stereogenic Alcohols: Bypassing Discrete Formation of Epimerizable Aldehydes

(2012) Daniel C. Schmitt et al.   ORGANIC LETTERS

Formation of C–C bonds via ruthenium-catalyzed transfer hydrogenation

(2012) Joseph Moran et al.   PURE AND APPLIED CHEMISTRY

Enantioselective C-H Crotylation of Primary Alcohols via Hydrohydroxyalkylation of Butadiene

(2012) J. R. Zbieg et al.   SCIENCE

The Growing Impact of Catalysis in the Pharmaceutical Industry

(2011) Carl A. Busacca et al.   ADVANCED SYNTHESIS & CATALYSIS

Iridium-Catalyzed anti-Diastereo- and Enantioselective Carbonyl (α-Trifluoromethyl)allylation from the Alcohol or Aldehyde Oxidation Level

(2011) Xin Gao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Iridium-Catalyzed Vinylogous Reformatsky-Aldol Reaction from the Alcohol Oxidation Level: Linear Regioselectivity by Way of Carbon-Bound Enolates

(2011) Abbas Hassan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Catalytic Approach to the Synthesis of (+)-Fluvastatin Analogue

(2011) Ae-Jin Kim et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Catalytic enantioselective Grignard Nozaki–Hiyama methallylation from the alcohol oxidation level: chloride compensates for π-complex instability

(2011) Abbas Hassan et al.   CHEMICAL COMMUNICATIONS

Catalytic Enantioselective Allylation of Carbonyl Compounds and Imines

(2011) Miguel Yus et al.   CHEMICAL REVIEWS

Direct Sp3α-C–H activation and functionalization of alcohol and ether

(2011) Shu-Yu Zhang et al.   CHEMICAL SOCIETY REVIEWS

The importance of Green Chemistry in Process Research and Development

(2011) Peter J. Dunn   CHEMICAL SOCIETY REVIEWS

Recent Advances in the Synthesis of α-Alkylidene-Substituted δ-Lactones, γ-Lactams and δ-Lactams

(2011) Anna Albrecht et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enhanced anti-Diastereo- and Enantioselectivity in Alcohol-Mediated Carbonyl Crotylation Using an Isolable Single Component Iridium Catalyst

(2011) Xin Gao et al.   JOURNAL OF ORGANIC CHEMISTRY

Direct Generation of Acyclic Polypropionate StereopolyadsviaDouble Diastereo- and Enantioselective Iridium-Catalyzed Crotylation of 1,3-Diols: Beyond Stepwise Carbonyl Addition in Polyketide Construction

(2011) Xin Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of Bryostatin 7viaC–C Bond-Forming Hydrogenation

(2011) Yu Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polarity Inversion of Donor–Acceptor Cyclopropanes: Disubstituted δ-Lactones via Enantioselective Iridium Catalysis

(2011) Joseph Moran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diastereo- and Enantioselective Ruthenium-Catalyzed Hydrohydroxyalkylation of 2-Silyl-butadienes: Carbonylsyn-Crotylation from the Alcohol Oxidation Level

(2011) Jason R. Zbieg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis and Biological Evaluation of Pederin, Psymberin, and Highly Potent Analogs

(2011) Shuangyi Wan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium-catalysed direct C–C coupling of methanol and allenes

(2011) Joseph Moran et al.   Nature Chemistry

Stereocontrolled Synthesis of the C8–C22 Fragment of Rhizopodin

(2011) Manuel Kretschmer et al.   ORGANIC LETTERS

Concise Formal Synthesis of (+)-Neopeltolide

(2011) Zhen Yang et al.   ORGANIC LETTERS

Unlocking Hydrogenation for C–C Bond Formation: A Brief Overview of Enantioselective Methods

(2011) Abbas Hassan et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Iridium-Catalyzed Hydrohydroxyalkylation of Butadiene: Carbonyl Crotylation

(2010) Jason R. Zbieg et al.   ADVANCED SYNTHESIS & CATALYSIS

Protecting-Group-Free Total Syntheses: A Challenging Approach

(2010) Emmanuel Roulland   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium-Catalyzedanti-Diastereo- and Enantioselective Carbonyl (Trimethylsilyl)allylation from the Alcohol or Aldehyde Oxidation Level

(2010) Soo Bong Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (+)-Roxaticin via C−C Bond Forming Transfer Hydrogenation: A Departure from Stoichiometric Chiral Reagents, Auxiliaries, and Premetalated Nucleophiles in Polyketide Construction

(2010) Soo Bong Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Carbonyl Reverse Prenylation from the Alcohol or Aldehyde Oxidation Level Employing 1,1-Dimethylallene as the Prenyl Donor

(2010) Soo Bong Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

anti-Diastereo- and Enantioselective Carbonyl (Hydroxymethyl)allylation from the Alcohol or Aldehyde Oxidation Level: Allyl Carbonates as Allylmetal Surrogates

(2010) Yong Jian Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amplification of Anti-Diastereoselectivity via Curtin−Hammett Effects in Ruthenium-Catalyzed Hydrohydroxyalkylation of 1,1-Disubstituted Allenes: Diastereoselective Formation of All-Carbon Quaternary Centers

(2010) Jason R. Zbieg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allenamide Hydro−Hydroxyalkylation: 1,2-Amino Alcohols via Ruthenium-Catalyzed Carbonylanti-Aminoallylation

(2010) Jason R. Zbieg et al.   ORGANIC LETTERS

Direct Ruthenium-Catalyzed C−C Coupling of Ethanol: Diene Hydro-hydroxyethylation To Form All-Carbon Quaternary Centers

(2010) Hoon Han et al.   ORGANIC LETTERS

Iridium-Catalyzed Reactions Involving Transfer Hydrogenation, Addition, N-Heterocyclization, and Alkylation Using Alcohols and Diols as Key Substrates

(2010) Yasushi Obora et al.   SYNLETT

A novel strategy towards the atorvastatin lactone

(2010) Pramod Sawant et al.   TETRAHEDRON

1,n-Glycols as Dialdehyde Equivalents in Iridium-Catalyzed Enantioselective Carbonyl Allylation and Iterative Two-Directional Assembly of 1,3-Polyols

(2009) Yu Lu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Renaissance of α-Methylene-γ-butyrolactones: New Synthetic Approaches

(2009) Russell R. A. Kitson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Redox Economy in Organic Synthesis

(2009) Noah Z. Burns et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective iridium-catalyzed carbonyl allylation from the alcohol oxidation level via transfer hydrogenation: minimizing pre-activation for synthetic efficiency

(2009) Soo Bong Han et al.   CHEMICAL COMMUNICATIONS

Hydrogen Autotransfer in theN-Alkylation of Amines and Related Compounds using Alcohols and Amines as Electrophiles

(2009) Gabriela Guillena et al.   CHEMICAL REVIEWS

Dehydrogenation as a Substrate-Activating Strategy in Homogeneous Transition-Metal Catalysis

(2009) Graham E. Dobereiner et al.   CHEMICAL REVIEWS

The economies of synthesis

(2009) Timothy Newhouse et al.   CHEMICAL SOCIETY REVIEWS

Direct Vinylation of Alcohols or Aldehydes Employing Alkynes as Vinyl Donors: A Ruthenium Catalyzed C−C Bond-Forming Transfer Hydrogenation

(2009) Ryan L. Patman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Carbonyl Reverse Prenylation from the Alcohol or Aldehyde Oxidation Level Employing 1,1-Dimethylallene as the Prenyl Donor

(2009) Soo Bong Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

anti-Diastereo- and Enantioselective Carbonyl Crotylation from the Alcohol or Aldehyde Oxidation Level Employing a Cyclometallated Iridium Catalyst: α-Methyl Allyl Acetate as a Surrogate to Preformed Crotylmetal Reagents

(2009) In Su Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protecting-group-free synthesis as an opportunity for invention

(2009) Ian S. Young et al.   Nature Chemistry

Elongation of 1,3-Polyols via Iterative Catalyst-Directed Carbonyl Allylation from the Alcohol Oxidation Level

(2009) Abbas Hassan et al.   ORGANIC LETTERS

De novo asymmetric syntheses of (+)-goniothalamin, (+)-goniothalamin oxide, and 7,8-bis-epi-goniothalamin using asymmetric allylations

(2009) Philip Harsh et al.   TETRAHEDRON

Catalytic Carbonyl Addition through Transfer Hydrogenation: A Departure from Preformed Organometallic Reagents

(2008) John F. Bower et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Carbonyl Propargylation from the Alcohol or Aldehyde Oxidation Level Employing 1,3‐Enynes as Surrogates to Preformed Allenylmetal Reagents: A Ruthenium‐Catalyzed CC Bond‐Forming Transfer Hydrogenation

(2008) Ryan L. Patman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transition metal catalysed reactions of alcohols using borrowing hydrogen methodology

(2008) Tracy D. Nixon et al.   DALTON TRANSACTIONS

Enantioselective Iridium-Catalyzed Carbonyl Allylation from the Alcohol or Aldehyde Oxidation Level Using Allyl Acetate as an Allyl Metal Surrogate

(2008) In Su Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Iridium-Catalyzed Carbonyl Allylation from the Alcohol or Aldehyde Oxidation Level via Transfer Hydrogenative Coupling of Allyl Acetate: Departure from Chirally Modified Allyl Metal Reagents in Carbonyl Addition

(2008) In Su Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ruthenium-Catalyzed C−C Bond Forming Transfer Hydrogenation: Carbonyl Allylation from the Alcohol or Aldehyde Oxidation Level Employing Acyclic 1,3-Dienes as Surrogates to Preformed Allyl Metal Reagents

(2008) Fumitoshi Shibahara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium-Catalyzed C−C Coupling via Transfer Hydrogenation:  Carbonyl Addition from the Alcohol or Aldehyde Oxidation Level Employing 1,3-Cyclohexadiene

(2008) John F. Bower et al.   ORGANIC LETTERS