Dissecting the Multiplicity of Immune Effects of Immunosuppressive Drugs to Better Predict the Risk of de novo Malignancies in Solid Organ Transplant Patients

Targeting myeloid-derived suppressor cells for cancer immunotherapy

(2018) Yijun Liu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Reduction of myeloid-derived suppressor cells reinforces the anti-solid tumor effect of recipient leukocyte infusion in murine neuroblastoma-bearing allogeneic bone marrow chimeras

(2018) Isabelle Dierckx de Casterlé et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

High-throughput sequencing of the immune repertoire in oncology: Applications for clinical diagnosis, monitoring, and immunotherapies

(2018) Baixin Ye et al.   CANCER LETTERS

Mass cytometry: a powerful tool for dissecting the immune landscape

(2018) Yannick Simoni et al.   CURRENT OPINION IN IMMUNOLOGY

Molecular insight into targeting the NK cell immune response to cancer

(2018) Jai Rautela et al.   IMMUNOLOGY AND CELL BIOLOGY

B Regulatory Cells: Players in Pregnancy and Early Life

(2018) Ana Esteve-Solé et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Azathioprine to mycophenolate mofetil transition and risk of squamous cell carcinoma after lung transplantation

(2018) Martin Vos et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Azathioprine and risk of multiple keratinocyte cancers

(2018) Hyunje G. Cho et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Etiology of increased cancer incidence after solid organ transplantation

(2018) Sergio A. Acuna   Transplantation Reviews

Current Concepts of Antigen Cross-Presentation

(2018) Maria Embgenbroich et al.   Frontiers in Immunology

Langerhans Cells: Sensing the Environment in Health and Disease

(2018) Julie Deckers et al.   Frontiers in Immunology

Survival after the diagnosis of de novo malignancy in liver transplant recipients

(2018) Martina Taborelli et al.   INTERNATIONAL JOURNAL OF CANCER

Optimal oncologic management and mTOR inhibitor introduction are safe and improve survival in kidney and liver allograft recipients with de novo carcinoma

(2018) B. Rousseau et al.   INTERNATIONAL JOURNAL OF CANCER

A New Perspective: Exploring Future Therapeutic Strategies For Cancer By Understanding The Dual Role Of B Lymphocytes In Tumor Immunity

(2018) Min Liu et al.   INTERNATIONAL JOURNAL OF CANCER

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

(2018) Gareth J. Inman et al.   Nature Communications

Mass Cytometry for the Assessment of Immune Reconstitution After Hematopoietic Stem Cell Transplantation

(2018) Lauren Stern et al.   Frontiers in Immunology

Clinically-Relevant Rapamycin Treatment Regimens Enhance CD8+ Effector Memory T Cell Function In The Skin and Allow their Infiltration into Cutaneous Squamous Cell Carcinoma

(2018) Ji-Won Jung et al.   OncoImmunology

T lymphocyte subsets in cancer immunity: Friends or foes

(2018) Dounia Chraa et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Dendritic cell subsets

(2017) Christophe Macri et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Tissue-resident Lymphocytes in Solid Organ Transplantation

(2017) Amy C. Prosser et al.   TRANSPLANTATION

The Immune Response to Epstein Barr Virus and Implications for Posttransplant Lymphoproliferative Disorder

(2017) Olivia M. Martinez et al.   TRANSPLANTATION

The mTOR signal regulates myeloid-derived suppressor cells differentiation and immunosuppressive function in acute kidney injury

(2017) Chao Zhang et al.   Cell Death & Disease

Induction of resident memory T cells enhances the efficacy of cancer vaccine

(2017) Mevyn Nizard et al.   Nature Communications

Myeloid-Derived Suppressor Cells

(2017) Dmitry I. Gabrilovich   Cancer Immunology Research

Single and combined effect of retinoic acid and rapamycin modulate the generation, activity and homing potential of induced human regulatory T cells

(2017) Enzo Candia et al.   PLoS One

Implications of Resident Memory T Cells for Transplantation

(2016) L. K. Beura et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Immunosuppressive Medications and Squamous Cell Skin Carcinoma: Nested Case-Control Study Within the Skin Cancer after Organ Transplant (SCOT) Cohort

(2016) A. E. Coghill et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Peripheral Blood Epstein-Barr Viral Nucleic Acid Surveillance as a Marker for Posttransplant Cancer Risk

(2016) V. R. Dharnidharka   AMERICAN JOURNAL OF TRANSPLANTATION

Azathioprine and Risk of Skin Cancer in Organ Transplant Recipients: Systematic Review and Meta-Analysis

(2016) Z. Jiyad et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Transcriptional Control of Dendritic Cell Development

(2016) Theresa L. Murphy et al.   Annual Review of Immunology

Élie Metchnikoff, father of phagocytosis

(2016) Harold Ellis   BRITISH JOURNAL OF HOSPITAL MEDICINE

Density and Polarization States of Tumor-Associated Macrophages in Human Cutaneous Squamous Cell Carcinomas Arising in Solid Organ Transplant Recipients

(2016) Nika Cyrus et al.   DERMATOLOGIC SURGERY

Amelioration of autoimmune arthritis by adoptive transfer of Foxp3-expressing regulatory B cells is associated with the Treg/Th17 cell balance

(2016) Mi Kyung Park et al.   Journal of Translational Medicine

mTOR inhibitors effects on regulatory T cells and on dendritic cells

(2016) Giovanni Stallone et al.   Journal of Translational Medicine

Rapamycin Prolongs Cardiac Allograft Survival in a Mouse Model by Inducing Myeloid-Derived Suppressor Cells

(2015) T. Nakamura et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Cancer stage at diagnosis in patients infected with the human immunodeficiency virus and transplant recipients

(2015) Meredith S. Shiels et al.   CANCER

HLA-G expression levels influence the tolerogenic activity of human DC-10

(2015) G. Amodio et al.   HAEMATOLOGICA

Regulatory B cell: New member of immunosuppressive cell club

(2015) Tingting Ding et al.   HUMAN IMMUNOLOGY

Immunosuppressant-Driven De Novo Malignant Neoplasms after Solid-Organ Transplant

(2015) Kelsey Billups et al.   Progress in Transplantation

Natural Killer Cells Mediate Long-term Kidney Allograft Injury

(2015) Zhu-Xu Zhang et al.   TRANSPLANTATION

HLA-G expression levels influence the tolerogenic activity of human DC-10

(2015) G. Amodio et al.   HAEMATOLOGICA

Circulating TGF-β1 and VEGF and risk of cancer among liver transplant recipients

(2015) Eric A. Engels et al.   Cancer Medicine

Differential Effects of Tacrolimus versus Sirolimus on the Proliferation, Activation and Differentiation of Human B Cells

(2015) Opas Traitanon et al.   PLoS One

The Role of Macrophages in the Development of Human Renal Allograft Fibrosis in the First Year After Transplantation

(2014) D. Toki et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Tissue-resident T cells,in situimmunity and transplantation

(2014) Damian L. Turner et al.   IMMUNOLOGICAL REVIEWS

The effect of mammalian target of rapamycin inhibition on T helper type 17 and regulatory T cell differentiationin vitroandin vivoin kidney transplant recipients

(2014) Kyoung Woon Kim et al.   IMMUNOLOGY

Clinical Significance of Myeloid-Derived Suppressor Cells in Human Renal Transplantation with Acute T Cell-Mediated Rejection

(2014) Fanhang Meng et al.   INFLAMMATION

Spontaneous Renal Allograft Acceptance Associated with "Regulatory" Dendritic Cells and IDO

(2014) C. H. Cook et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Derived Suppressor Cells Accumulate in Kidney Allograft Tolerance and Specifically Suppress Effector T Cell Expansion

(2014) A.-S. Dugast et al.   JOURNAL OF IMMUNOLOGY

The Oncogene ATF3 Is Potentiated by Cyclosporine A and Ultraviolet Light A

(2014) Piotr J. Dziunycz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Role of human papillomavirus in cutaneous squamous cell carcinoma: A meta-analysis

(2014) Jennifer Wang et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Alternatively activated macrophages in the pathogenesis of chronic kidney allograft injury

(2014) Yohei Ikezumi et al.   PEDIATRIC NEPHROLOGY

Inhibition of mTORC1 inhibits lytic replication of Epstein-Barr virus in a cell-type specific manner

(2014) Amy L Adamson et al.   Virology Journal

Understanding the Biology of Antigen Cross-Presentation for the Design of Vaccines Against Cancer

(2014) Cynthia M. Fehres et al.   Frontiers in Immunology

Cumulative incidence of cancer after solid organ transplantation

(2013) Erin C. Hall et al.   CANCER

Apoptotic cell administration enhances pancreatic islet engraftment by induction of regulatory T cells and tolerogenic dendritic cells

(2013) Cong Wu et al.   Cellular & Molecular Immunology

Rapamycin has suppressive and stimulatory effects on human plasmacytoid dendritic cell functions

(2013) P. P. C. Boor et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Conventional and Monocyte-Derived CD11b+ Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen

(2013) Maud Plantinga et al.   IMMUNITY

Rapamycin unbalances the polarization of human macrophages to M1

(2013) Alessia Mercalli et al.   IMMUNOLOGY

Fas Signal Promotes the Immunosuppressive Function of Regulatory Dendritic Cells via the ERK/β-Catenin Pathway

(2013) Cheng Qian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclosporine and tacrolimus have inhibitory effects on toll-like receptor signalling after liver transplantation

(2013) Jessica Howell et al.   LIVER TRANSPLANTATION

Incidence and long-term risk of de novo malignancies after liver transplantation with implications for prevention and detection

(2013) Harald Schrem et al.   LIVER TRANSPLANTATION

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice

(2013) Payal B Watchmaker et al.   NATURE IMMUNOLOGY

Impact of Commonly Used Transplant Immunosuppressive Drugs on Human NK Cell Function Is Dependent upon Stimulation Condition

(2013) Aislin C. Meehan et al.   PLoS One

Tacrolimus Inhibits NF-κB Activation in Peripheral Human T Cells

(2013) Ramin Vafadari et al.   PLoS One

Impact of cyclosporine versus tacrolimus on the incidence ofde novomalignancy following liver transplantation: a single center experience with 609 patients

(2013) Cosmas D. Wimmer et al.   TRANSPLANT INTERNATIONAL

Predictors of Cancer Risk in the Long-Term Solid-Organ Transplant Recipient

(2013) Sam N. Sherston et al.   TRANSPLANTATION

Cancer in the Transplant Recipient

(2013) J. R. Chapman et al.   Cold Spring Harbor Perspectives in Medicine

Cyclosporine A Impairs Nucleotide Binding Oligomerization Domain (Nod1)-Mediated Innate Antibacterial Renal Defenses in Mice and Human Transplant Recipients

(2013) Emilie Tourneur et al.   PLoS Pathogens

Effect of immunosuppressive drugs on spontaneous DNA repair in human peripheral blood mononuclear cells

(2012) Yaacov Ori et al.   BIOMEDICINE & PHARMACOTHERAPY

NFAT control of innate immunity

(2012) J. Fric et al.   BLOOD

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Management of Non-Melanoma Skin Cancer in Immunocompromised Solid Organ Transplant Recipients

(2012) Haider K. Bangash et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Rapamycin combined with allogenic immature dendritic cells selectively expands CD4+CD25+Foxp3+ regulatory T cells in rats

(2012) Guo-Ying Wang et al.   Hepatobiliary & Pancreatic Diseases International

Sirolimus and Secondary Skin-Cancer Prevention in Kidney Transplantation

(2012) Sylvie Euvrard et al.   NEW ENGLAND JOURNAL OF MEDICINE

Calcineurin Inhibitors Suppress Cytokine Production from Memory T Cells and Differentiation of Naïve T Cells into Cytokine-Producing Mature T Cells

(2012) Kenshiro Tsuda et al.   PLoS One

Dysregulation of Th17 Cells during the Early Post-Transplant Period in Patients under Calcineurin Inhibitor Based Immunosuppression

(2012) Byung Ha Chung et al.   PLoS One

Flt3L Combined with Rapamycin Promotes Cardiac Allograft Tolerance by Inducing Regulatory Dendritic Cells and Allograft Autophagy in Mice

(2012) Ali Xiong et al.   PLoS One

Release of dendritic cells from cognate CD4+ T-cell recognition results in impaired peripheral tolerance and fatal cytotoxic T-cell mediated autoimmunity

(2012) S. Muth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New concepts and best practices for management of pre- and post-transplantation cancer

(2012) Josep M. Campistol et al.   Transplantation Reviews

Reversal of UVA Skin Photosensitivity and DNA Damage in Kidney Transplant Recipients by Replacing Azathioprine

(2011) G. F. L. Hofbauer et al.   AMERICAN JOURNAL OF TRANSPLANTATION

NFIL3/E4BP4 is a key transcription factor for CD8 + dendritic cell development

(2011) M. Kashiwada et al.   BLOOD

Organ transplantation: historical perspective and current practice

(2011) C.J.E. Watson et al.   BRITISH JOURNAL OF ANAESTHESIA

Myeloid-derived suppressor cells impair the quality of dendritic cell vaccines

(2011) I. Poschke et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

(2011) Ashutosh Chaudhry et al.   IMMUNITY

Inhibition of macrophage activation and suppression of graft rejection by DTCM-glutarimide, a novel piperidine derived from the antibiotic 9-methylstreptimidone

(2011) Masatoshi Takeiri et al.   INFLAMMATION RESEARCH

The Role of Natural Killer Cells in Human Solid Organ and Tissue Transplantation

(2011) Jean Villard   Journal of Innate Immunity

IRF8Mutations and Human Dendritic-Cell Immunodeficiency

(2011) Sophie Hambleton et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Plasmacytoid dendritic cells: key players in the initiation and regulation of immune responses

(2010) Roberto Lande et al.   Annals of the New York Academy of Sciences

Cyclosporin A-treated Dendritic Cells may affect the outcome of organ transplantation by decreasing CD4+CD25+ regulatory T cell proliferation

(2010) Karina Pino-Lagos et al.   BIOLOGICAL RESEARCH

Regulatory dendritic cells program generation of interleukin-4-producing alternative memory CD4 T cells with suppressive activity

(2010) X. Xu et al.   BLOOD

Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway

(2010) S. Gregori et al.   BLOOD

PD-L1 expression on tolerogenic APCs is controlled by STAT-3

(2010) Sabine J. Wölfle et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The role of mTOR in memory CD8+ T-cell differentiation

(2010) Koichi Araki et al.   IMMUNOLOGICAL REVIEWS

Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice

(2010) Mercedes Rodriguez Garcia et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a B cell signature associated with renal transplant tolerance in humans

(2010) Kenneth A. Newell et al.   JOURNAL OF CLINICAL INVESTIGATION

A Versatile Role of Mammalian Target of Rapamycin in Human Dendritic Cell Function and Differentiation

(2010) M. Haidinger et al.   JOURNAL OF IMMUNOLOGY

Patients with drug-free long-term graft function display increased numbers of peripheral B cells with a memory and inhibitory phenotype

(2010) Annaick Pallier et al.   KIDNEY INTERNATIONAL

Increased incidence of early de novo cancer in liver graft recipients treated with cyclosporine: An association with C2 monitoring and recipient age

(2010) Angela S. W. Tjon et al.   LIVER TRANSPLANTATION

Patient Survival After the Diagnosis of Cancer in Renal Transplant Recipients: A Nested Case-Control Study

(2010) Jacqueline van de Wetering et al.   TRANSPLANTATION

Calcineurin Inhibitors Activate the Proto-Oncogene Ras and Promote Protumorigenic Signals in Renal Cancer Cells

(2009) D. Datta et al.   CANCER RESEARCH

Calcineurin inhibitors affect B cell antibody responses indirectly by interfering with T cell help

(2009) S. Heidt et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunoregulatory profiles in liver transplant recipients on different immunosuppressive agents

(2009) Josh Levitsky et al.   HUMAN IMMUNOLOGY

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

Rapamycin, unlike cyclosporine A, enhances suppressive functions of in vitro-induced CD4+CD25+ Tregs

(2009) K. Bocian et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Differential Responses of Human Regulatory T Cells (Treg) and Effector T Cells to Rapamycin

(2009) Laura Strauss et al.   PLoS One

Mycophenolate mofetil: effects on cellular immune subsets, infectious complications, and antimicrobial activity

(2009) M.L. Ritter et al.   Transplant Infectious Disease

Rapamycin-treated mature dendritic cells have a unique cytokine secretion profile and impaired allostimulatory capacity

(2009) Guo-Ying Wang et al.   TRANSPLANT INTERNATIONAL

Rapamycin, But Not Cyclosporine or FK506, Alters Natural Killer Cell Function

(2009) Lu-En Wai et al.   TRANSPLANTATION

De Novo Cancers Arising in Organ Transplant Recipients are Associated With Adverse Outcomes Compared With the General Population

(2009) Yun Miao et al.   TRANSPLANTATION

Azathioprine treatment photosensitizes human skin to ultraviolet A radiation

(2008) C.M. Perrett et al.   BRITISH JOURNAL OF DERMATOLOGY

Frequent Detection of Merkel Cell Polyomavirus in Human Merkel Cell Carcinomas and Identification of a Unique Deletion in the VP1 Gene

(2008) A. Kassem et al.   CANCER RESEARCH

Proteomics analysis in post-transplant lymphoproliferative disorders

(2008) Yazan Alsayed et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Poor allostimulatory function of liver plasmacytoid DC is associated with pro-apoptotic activity, dependent on regulatory T cells

(2008) Daisuke Tokita et al.   JOURNAL OF HEPATOLOGY

MC Polyomavirus Is Frequently Present in Merkel Cell Carcinoma of European Patients

(2008) Jürgen C. Becker et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

(2008) K. Hildner et al.   SCIENCE

Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma

(2008) H. Feng et al.   SCIENCE

Effects of Immunosuppressive Drugs On Purified Human B Cells: Evidence Supporting the Use of MMF and Rapamycin

(2008) Sebastiaan Heidt et al.   TRANSPLANTATION