NFAT control of innate immunity

HIF-1  Is Up-Regulated in Activated Mast Cells by a Process That Involves Calcineurin and NFAT

(2014) A. Walczak-Drzewiecka et al.   JOURNAL OF IMMUNOLOGY

Calcineurin/NFAT signalling inhibits myeloid haematopoiesis

(2012) Jan Fric et al.   EMBO Molecular Medicine

Gene expression induced by Toll-like receptors in macrophages requires the transcription factor NFAT5

(2012) Maria Buxadé et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Cell Permeable Peptide Inhibitor of NFAT Inhibits Macrophage Cytokine Expression and Ameliorates Experimental Colitis

(2012) Houda Z. Elloumi et al.   PLoS One

Innate Antifungal Immunity: The Key Role of Phagocytes

(2011) Gordon D. Brown   Annual Review of Immunology

Local delivery of IL-2 reduces atherosclerosis via expansion of regulatory T cells

(2011) Thore Dietrich et al.   ATHEROSCLEROSIS

IL-2 production by dendritic cells promotes Foxp3+regulatory T-cell expansion in autoimmune-resistant NOD congenic mice

(2011) Evridiki Sgouroudis et al.   AUTOIMMUNITY

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

The dendritic cell life cycle

(2011) Francesca Granucci et al.   CELL CYCLE

Mast cells promote Th1 and Th17 responses by modulating dendritic cell maturation and function

(2011) Anne Dudeck et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses

(2011) Diego Mourão-Sá et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Osteomyelosclerosis, anemia and extramedullary hematopoiesis in mice lacking the transcription factor NFATc2

(2011) W. Bauer et al.   HAEMATOLOGICA

Mast Cell Interleukin-2 Production Contributes to Suppression of Chronic Allergic Dermatitis

(2011) Alon Y. Hershko et al.   IMMUNITY

The Calcium Sensors STIM1 and STIM2 Control B Cell Regulatory Function through Interleukin-10 Production

(2011) Masanori Matsumoto et al.   IMMUNITY

Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3+ Regulatory T Cells in the Lamina Propria

(2011) Usriansyah Hadis et al.   IMMUNITY

Similarities and differences of innate immune responses elicited by smooth and rough LPS

(2011) Ivan Zanoni et al.   IMMUNOLOGY LETTERS

CCAAT/Enhancer-binding Protein α (C/EBPα) Is Critical for Interleukin-4 Expression in Response to FcϵRI Receptor Cross-linking

(2011) Xiaopeng Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

(2011) Helen S. Goodridge et al.   NATURE

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

(2011) Zhihua Liu et al.   NATURE IMMUNOLOGY

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex

(2011) S. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deciphering the complexity of Toll-like receptor signaling

(2010) Renato Ostuni et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mast cells in allergy and infection: Versatile effector and regulatory cells in innate and adaptive immunity

(2010) Stephen J. Galli et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Frequent Calcium Oscillations Lead to NFAT Activation in Human Immature Dendritic Cells

(2010) Mirko Vukcevic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcineurin regulates innate antifungal immunity in neutrophils

(2010) Matthew B. Greenblatt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dendritic Cell Apoptosis: Regulation of Tolerance versus Immunity

(2010) R. Kushwah et al.   JOURNAL OF IMMUNOLOGY

FK506 causes cellular and functional defects in human natural killer cells

(2010) Tae-Jin Kim et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Monitoring immunosuppression with measures of NFAT decreases cancer incidence

(2009) Thomas Giese et al.   CLINICAL IMMUNOLOGY

Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiation

(2009) Takako Negishi-Koga et al.   IMMUNOLOGICAL REVIEWS

β-glucan recognition by the innate immune system

(2009) Helen S. Goodridge et al.   IMMUNOLOGICAL REVIEWS

Calcineurin inactivation leads to decreased responsiveness to LPS in macrophages and dendritic cells and protects against LPS-induced toxicity in vivo

(2009) Charay Jennings et al.   Innate Immunity

Phospholipase Cγ2 Is Critical for Dectin-1-mediated Ca2+Flux and Cytokine Production in Dendritic Cells

(2009) Shengli Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activated Dectin-1 Localizes to Lipid Raft Microdomains for Signaling and Activation of Phagocytosis and Cytokine Production in Dendritic Cells

(2009) Shengli Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation

(2009) Ivan Zanoni et al.   NATURE

Basophils contribute to TH2-IgE responses in vivo via IL-4 production and presentation of peptide–MHC class II complexes to CD4+ T cells

(2009) Tomohiro Yoshimoto et al.   NATURE IMMUNOLOGY

Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-κB activation through Raf-1 and Syk

(2009) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response

(2009) Caroline L Sokol et al.   NATURE IMMUNOLOGY

Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development

(2009) M. R. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NK cell-activating receptors require PKC-  for sustained signaling, transcriptional activation, and IFN-  secretion

(2008) I. Tassi et al.   BLOOD

NFAT but not NF- B is critical for transcriptional induction of the prosurvival gene A1 after IgE receptor activation in mast cells

(2008) E. Ulleras et al.   BLOOD

Nuclear factor of activated T cells (NFAT) mediates CD154 expression in megakaryocytes

(2008) S. A. Crist et al.   BLOOD

NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells

(2008) Valerie Horsley et al.   CELL

A distal cis-regulatory element, CNS-9, controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells

(2008) Choong-Gu Lee et al.   MOLECULAR IMMUNOLOGY

Priming for T helper type 2 differentiation by interleukin 2–mediated induction of interleukin 4 receptor α-chain expression

(2008) Wei Liao et al.   NATURE IMMUNOLOGY

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY