Article
Dermatology
Ricardo Moreno-Alonso de Celada, Tamara Gracia-Cazana, Laura Najera-Botello, Paulina Cerro-Munoz, Angeles Juarranz, Salvador Gonzalez, Yolanda Gilaberte
Summary: This study aimed to evaluate the association between serum and immunohistochemical parameters and the response of actinic keratoses (AK) to treatment with topical ingenol mebutate (IM). The results suggest a relationship between serum vitamin D (VD) levels and vitamin D receptor (VDR) basal expression with the response of AK to treatment with IM.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Patrick Michael Jedlowski
Summary: The study found a significant association between ingenol mebutate and squamous cell carcinoma (SCC) in patients with actinic keratosis (AK) based on data from the FDA Adverse Event Reporting System (FAERS). The association remained significant after controlling for bias and other factors, and it was found to be stronger than the association with another topical AK medication, imiquimod.
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2023)
Article
Dermatology
Jason Thomson, Findlay Bewicke-Copley, Chinedu Anthony Anene, Abha Gulati, Ai Nagano, Karin Purdie, Gareth J. Inman, Charlotte M. Proby, Irene M. Leigh, Catherine A. Harwood, Jun Wang
Summary: This study conducted the largest AK whole exome sequencing study to date and found significant similarities between AK and cSCC in terms of genetic mutations, copy number alterations, driver gene mutations, and mutational signatures. The research identified 44 significantly mutated AK driver genes and suggested that dysregulated TGFf3 signaling may play an important role in AK-cSCC progression.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dermatology
Chiara Cortelazzi, Giulia Odorici, Elisa Castagnetti, Giovanni Pellacani, Sergio Di Nuzzo
Summary: Both imiquimod and MAL-PDT are effective in reducing the number of actinic keratosis lesions, with imiquimod having a slightly higher overall clearance rate. Adverse effects are common but transient for both treatments, with excellent aesthetic results. A combination or sequential therapy may optimize the management of actinic keratosis.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Domenico Arcuri, Brandon Ramchatesingh, Francois Lagace, Lisa Iannattone, Elena Netchiporouk, Philippe Lefrancois, Ivan V. Litvinov
Summary: Actinic keratosis, a common skin disease, can be life-threatening if left untreated. Pharmacologic agents such as nicotinamide, acitretin, and 5-fluorouracil (5-FU) are used in prevention and treatment of AKs. 5-FU is considered the most effective therapy, but lower concentrations may also be effective. Uncertainty remains regarding the optimal treatment for immunocompetent vs. immunodeficient/immunosuppressed patients. Photodynamic light therapy is also an accepted treatment strategy for AKs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Daniel B. Eisen, Maryam M. Asgari, Daniel D. Bennett, Suzanne M. Connolly, Robert P. Dellavalle, Esther E. Freeman, Gary Goldenberg, David J. Leffell, Sue Peschin, James E. Sligh, Peggy A. Wu, Lindsy Frazer-Green, Sameer Malik, Todd E. Schlesinger
Summary: This analysis reviewed the literature related to the management of AK to provide evidence-based recommendations for treatment. Strong recommendations were made for using ultraviolet protection, topical medications, and cryosurgery to treat AK. Conditional recommendations were made for photodynamic therapy and diclofenac for the treatment of AK.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Daniel B. Eisen, Maryam M. Asgari, Daniel D. Bennett, Suzanne M. Connolly, Robert P. Dellavalle, Esther E. Freeman, Gary Goldenberg, David J. Leffell, Sue Peschin, James E. Sligh, Peggy A. Wu, Lindsy Frazer-Green, Sameer Malik, Todd E. Schlesinger
Summary: This study provides a summary of 18 evidence-based recommendations for the treatment of actinic keratoses, highlighting the effectiveness of treatments such as ultraviolet protection, topical medications, and cryosurgery. The recommendations are subject to limitations, and future research may alter current treatment guidelines.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Hannah Peterson, Janiene Luke
Summary: Actinic keratosis is a premalignant skin lesion that can progress to squamous cell carcinoma. Ingenol mebutate, derived from the sap of the Euphorbia peplus plant, is approved for treating actinic keratoses. This article discusses the mechanism of action, administration, dosage, patient education, adverse effects, and alternative medications of ingenol mebutate.
JOURNAL OF THE DERMATOLOGY NURSES ASSOCIATION
(2021)
Article
Dermatology
Rita de Cassia Rossini, Gerson Dellatorre, Lismary Aparecida de Forville Mesquita, Roberto Gomes Tarle
Summary: The study demonstrated that treatment with IM gel significantly improved local skin reactions in patients with AC, but did not show statistically significant histopathological or immunohistochemical response, indicating that clinical improvement may not be accompanied by complete histopathological cure.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2021)
Article
Biochemistry & Molecular Biology
Helene Dubois-Pot-Schneider, Gregoire Khairallah, Cyril Brzenczek, Francois Plenat, Frederic Marchal, Marine Amouroux
Summary: Actinic keratoses (AKs) are common sun-damaged skin areas, and there is a need for objective identification of different AK types. This study identified two molecular profiles of AKs, lesional AKs (AK_Ls) with similarity to squamous cell carcinomas and non-lesional AKs (AK_NLs) with similarity to normal skin tissue. The gene expression analysis revealed differences in inflammatory and keratinization-related genes between the two AK classes and suggested the potential of targeting the VEGF pathway for high-risk lesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Elena Campione, Monia Di Prete, Cosimo Di Raimondo, Gaetana Costanza, Vincenzo Palumbo, Virginia Garofalo, Sara Mazzilli, Chiara Franceschini, Emi Dika, Luca Bianchi, Augusto Orlandi
Summary: This study evaluated the clinical efficacy of three different therapeutic modalities for actinic keratosis and assessed the expression of matrix metalloproteinases through histopathological examination and immunohistochemistry. The results showed a gradual decrease in actinic keratosis assessment scores at the end of treatments and a reduction in matrix metalloproteinase expression in treated skin lesions compared to baseline.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Ryo Tanaka, Keiji Tanese, Yingyao Zhu, Yumi Fujio, Izumi Konohana, Yuichi Kurihara
Summary: Treatment response to topical imiquimod therapy for actinic keratosis is related to clinical and pathological characteristics, with lesions showing follicular extension being less responsive to treatment. Lesions without follicular extension had a higher complete response rate of 92.6%.
JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
D. Y. Lee, B. R. Kim, S. Yang, M. Kim, T. Y. Yoon, S. W. Youn
Summary: This study quantitatively assessed histopathological findings of actinic keratosis (AK) and identified bowenoid type, epidermal thickening, and higher proportion of keratinocytic atypia as significant factors associated with progression to invasive squamous cell carcinoma (SCC). Multivariate analysis revealed that the proportion of keratinocytic atypia was the only independent predisposing factor for SCC progression.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Dermatology
Vivian Lindholm, Mari Salmivuori, Sonja Hahtola, Kerttu Makela, Sari Pitkanen, Kirsi Isoherranen
Summary: Artificial daylight photodynamic therapy is an effective and painless treatment for actinic keratoses. This study found that fractional laser pre-treatment significantly improves the outcomes of daylight photodynamic therapy, regardless of the grade of actinic keratoses. Additionally, there was no significant difference in outcomes between artificial and natural daylight photodynamic therapy.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Dermatology
Soo Ick Cho, Hanjae Lee, Soyun Cho
Summary: According to this study, patients with rosacea have an increased risk of developing actinic keratosis and keratinocyte carcinoma, while the risk of cutaneous melanoma and gastric, colorectal, and liver cancer is not increased.
ACTA DERMATO-VENEREOLOGICA
(2022)
Review
Physiology
Diana A. Yanez, Richard K. Lacher, Aurobind Vidyarthi, Oscar R. Colegio
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2017)
Editorial Material
Immunology
Rachel K. Rosenstein, Christine J. Ko, Oscar R. Colegio
Letter
Dermatology
Mariam B. Totonchy, Oscar R. Colegio, Sean R. Christensen
Article
Dermatology
Giorgia L. Garrett, Paul D. Blanc, John Boscardin, Amanda Abramson Lloyd, Rehana L. Ahmed, Tiffany Anthony, Kristin Bibee, Andrew Breithaupt, Jennifer Cannon, Amy Chen, Joyce Y. Cheng, Zelma Chiesa-Fuxench, Oscar R. Colegio, Clara Curiel-Lewandrowski, Christina A. Del Guzzo, Max Disse, Margaret Dowd, Robert Eilers, Arisa Elena Ortiz, Caroline Morris, Spring K. Golden, Michael S. Graves, John R. Griffin, Samuel Hopkins, Conway C. Huang, Gordon Hyeonjin Bae, Anokhi Jambusaria, Thomas A. Jennings, Shang I. Brian Jiang, Pritesh S. Karia, Shilpi Khetarpal, Changhyun Kim, Goran Klintmalm, Kathryn Konicke, Shlomo A. Koyfman, Charlene Lam, Peter Lee, Justin J. Leitenberger, Tiffany Loh, Stefan Lowenstein, Reshmi Madankumar, Jacqueline F. Moreau, Rajiv I. Nijhawan, Shari Ochoa, Edit B. Olasz, Elaine Otchere, Clark Otley, Jeremy Oulton, Parth H. Patel, Vishal Anil Patel, Arpan V. Prabhu, Melissa Pugliano-Mauro, Chrysalyne D. Schmults, Sarah Schram, Allen F. Shih, Thuzar Shin, Seaver Soon, Teresa Soriano, Divya Srivastava, Jennifer A. Stein, Kara Sternhell-Blackwell, Stan Taylor, Allison Vidimos, Peggy Wu, Nicholas Zajdel, Daniel Zelac, Sarah T. Arron
Article
Dermatology
Giorgia L. Garrett, Joyce T. Yuan, Thuzar M. Shin, Sarah T. Arron
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2018)
Article
Dermatology
Joyce Y. Cheng, Fang-Yong Li, Christine J. Ko, Oscar R. Colegio
Article
Immunology
Aurobind Vidyarthi, Nargis Khan, Tapan Agnihotri, Shikha Negi, Deepjyoti K. Das, Mohammad Aqdas, Deepyan Chatterjee, Oscar R. Colegio, Manoj K. Tewari, Javed N. Agrewala
FRONTIERS IN IMMUNOLOGY
(2018)
Letter
Dermatology
Allen F. Shih, Wendy Sun, Cameron Yick, Suzanne Xu, Rance J. T. Fujiwara, Oscar R. Colegio
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2019)
Letter
Dermatology
Joyce Y. Cheng, Fang-Yong Li, Mike Wang, Oscar R. Colegio
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Eftekhar Rajab Bolookat, Laurie J. Rich, Gyorgy Paragh, Oscar R. Colegio, Anurag K. Singh, Mukund Seshadri
APPLIED SCIENCES-BASEL
(2020)
Article
Multidisciplinary Sciences
Xiaodong Jiang, Mike Wang, Nika Cyrus, Diana A. Yanez, Richard K. Lacher, Anne Marie Rhebergen, Carolyn Brokowski, Anjela Galan, Samuel Book, Oscar R. Colegio
Review
Surgery
M. Ilyas, O. R. Colegio, B. Kaplan, A. Sharma
AMERICAN JOURNAL OF TRANSPLANTATION
(2017)
Review
Surgery
A. Mittal, O. R. Colegio
AMERICAN JOURNAL OF TRANSPLANTATION
(2017)