Article
Cell Biology
Francesca Marcon, Roberta Meschini, Egidio Iorio, Simonetta Palleschi, Gabriele De Luca, Ester Siniscalchi, Luigi Conti, Mattea Chirico, Maria Elena Pisanu, Francesca De Battistis, Barbara Rossi, Anna Minoprio, Alessandro Giuliani, Peter Karran, Margherita Bignami
Summary: hMTH1 protects against mutation during oxidative stress by degrading oxidized guanine in DNA. Its overexpression ameliorates the effects of a high-fat diet challenge in young mice, including weight gain, liver metabolism changes, and DNA damage. However, these protective effects are less significant in adult mice, indicating a redundant role of hMTH1 in non-growing, differentiated tissues. The lifelong protection against micronucleus induction conferred by hMTH1 overexpression may contribute to the extended longevity observed in hMTH1-Tg mice.
Article
Chemistry, Analytical
Wen Zhang, Simin Bi, Ping Li, Jihong Liu, Chunmiao Zhou, Xin Wang, Wei Zhang, Hui Wang, Bo Tang
Summary: This study developed a mitochondria-targeting fluorescent probe to investigate the role of mitochondrial DNA in liver IR injury, revealing a correlation between mtDNA damage and worsening IR injury, as well as identifying two potential drugs with superior therapeutic efficacy in preventing IR injury.
ANALYTICAL CHEMISTRY
(2021)
Article
Environmental Sciences
Ruijia Zhang, Lanyin Tu, Yuanzhu Yang, Jin Sun, Tong Liang, Yizheng Li, Ruohong Chen, Baowei Chen, Tiangang Luan
Summary: Human exposure to arsenic in drinking water is a global health concern. This study investigated the intracellular sources of reactive oxygen species (ROS) and the oxidative impairments caused by arsenite (iAsIII) toxicity. NADPH oxidase (NOX) was found to be the primary pathway of ROS overproduction, accounting for nearly 60.0% of total ROS. iAsIII also induced mitochondrial superoxide anion, impairing mitochondrial respiratory function and decreasing ATP production. The inhibition of NOX activity rescued mitochondrial membrane potential. Purine and glycerophospholipids metabolisms were disrupted by iAsIII, indicating DNA and plasma membrane damages. This study provides insights into the mechanisms of iAsIII toxicity related to oxidative stress.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Nutrition & Dietetics
Premranjan Kumar, Ob W. Osahon, Rajagopal V. Sekhar
Summary: This study found that supplementing GlyNAC can increase the lifespan of mice and improve multiple age-associated defects. GlyNAC could be a new nutritional supplement to improve lifespan and healthspan.
Article
Biochemistry & Molecular Biology
Shenping Li, Junjie Deng, Dandan Sun, Shimei Chen, Xieyi Yao, Ning Wang, Jian Zhang, Qing Gu, Shuchang Zhang, Jing Wang, Shaopin Zhu, Hong Zhu, Huiming Li, Xun Xu, Fang Wei
Summary: Diabetic retinopathy and other diabetic vascular complications are the leading cause of death and disability in patients with suboptimum glycemic control. In the pathogenesis of these complications, hyperglycemia-induced oxidative stress, DNA damage, and hyperactivation of PARP play important roles in endothelial cell impairment. The protein FBXW7 has been found to play a crucial role in repairing DNA damage and reducing oxidative stress. Additionally, FBXW7 can regulate PARP activation and improve mitochondrial function, providing a potential new method for treating diabetic vascular complications.
Article
Biochemistry & Molecular Biology
Zhaoyang Wang, Ziyi Li, Yaling Lei, Yuan Liu, Yuqing Feng, Derong Chen, Siying Ma, Ziyan Xiao, Meirong Hu, Jingxian Deng, Yuxin Wang, Qihao Zhang, Yadong Huang, Yan Yang
Summary: In this study, a recombinant photolyase-thymine (rPHO) from Thermus thermophilus was found to efficiently repair UVB-induced DNA photoproducts and exhibit promising protective effects against photoaging and skin carcinogenesis.
Review
Cell Biology
Owen Davis Sanders, Lekshmy Rajagopal, Chandler Chase Barton, Jayalekshmi Archa Rajagopal, Olga Lopez, Kalei Lopez, Fayeza Malik
Summary: The low cerebral metabolic rate of oxygen in Alzheimer's disease patients' medial temporal lobes suggests mitochondrial dysfunction caused by oxidative stress and DNA damage, which may contribute to tissue hypoxia. This finding helps us to better understand the pathogenesis of Alzheimer's disease.
Review
Geriatrics & Gerontology
S. G. Chowdhury, S. Misra, Parimal Karmakar
Summary: Ageing is a multi-factorial phenomenon, and accumulation of DNA damage or mutations is a dominant theory which contributes largely to the development of ageing and age-related diseases. Obesity is a complex chronic disease that affects multiple organs and tissues, and it has been found to be associated with higher loads of DNA damage. The present review focuses on the involvement of DNA metabolism in the development of obesity and how it accelerates ageing in mammals.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Article
Biochemistry & Molecular Biology
Ju Ri Ham, Ra-Yeong Choi, Yongjin Lee, Mi-Kyung Lee
Summary: The study shows that replacing soy protein (SP) with mealworm fermentation extract (TMP) can help reduce body weight, improve hepatic steatosis, and alleviate insulin resistance in mice, potentially through the regulation of specific protein profiles involved in metabolism and stress responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Naserddine Hamadi, Sumaya Beegam, Nur Elena Zaaba, Ozaz Elzaki, Mariam Abdulla Altamimi, Abderrahim Nemmar
Summary: Waterpipe smoking (WPS) is popular in Asian and Middle Eastern countries and has gained popularity worldwide, especially among youth. Chronic exposure to WPS is associated with inflammation, oxidative stress, apoptosis, microgliosis, and astrogliosis in the cerebellum. These effects involve the activation of NF-kappa B.
Editorial Material
Plant Sciences
Moira Rodriguez, Ana Martinez-Hottovy, Alan C. Christensen
Summary: Plant mtDNA can be repaired through homologous recombination, and mitochondrial interactions may influence genetic behavior.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Biochemistry & Molecular Biology
Fabiano Cimmino, Angela Catapano, Giovanna Trinchese, Gina Cavaliere, Rosanna Culurciello, Chiara Fogliano, Eduardo Penna, Valeria Lucci, Marianna Crispino, Bice Avallone, Elio Pizzo, Maria Pina Mollica
Summary: Obesity and metabolic disturbances are increasing globally due to unhealthy diets and lack of physical activity, leading to non-communicable diseases. Nutritional components can modulate metabolic homeostasis, with DMG-gold showing promise in preventing or delaying NCD onset.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Lili Xin, Jiaojiao Sun, Xuedi Zhai, Xiaoyu Chen, Jianmei Wan, Hailin Tian
Summary: This study aimed to investigate the potential molecular mechanism underlying radon-induced lung damage. The results showed that long-term radon exposure caused mitochondrial damage and redox imbalance in BEAS-2B cells, as well as time-dependent lung pathological injury in mice. Increasing radon exposure time led to the activation of Nrf-2 and its downstream antioxidants, along with the induction of specified markers involved in different stages of autophagy. The gene expression changes of PINK-1, Parkin, and p62 induced by radon exposure differed between BEAS-2B cells and mice, indicating different mechanisms of mitophagy activation and profiles of autophagic flux. These findings demonstrate that long-term radon exposure damages bronchial epithelial cells and the lungs by increasing oxidative stress, decreasing mitochondrial function, and activating mitophagy with different profiles of autophagic flux. The study also reveals Nrf-2 as a central regulator of mitochondrial homeostasis and lung damage.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Environmental Sciences
Hiba Hamdi, Imen Graiet, Salwa Abid-Essefi, Joel Eyer
Summary: This study revealed that oral exposure to EPX caused oxidative stress, lipid peroxidation, protein oxidation, DNA fragmentation, impaired antioxidant enzyme activities, and histological alterations in the brain of adult rats. In embryonic neural stem cells, EPX treatment reduced cell viability, proliferation, induced cell cycle arrest, and disrupted cytoskeleton, ultimately leading to apoptosis. Pretreatment with N-acetylcysteine attenuated the toxic effects of EPX on neural stem cells.
Article
Cell Biology
Ling Wang, Zeyuan Lu, Juan Zhao, Madison Schank, Dechao Cao, Xindi Dang, Lam Nhat Nguyen, Lam Ngoc Thao Nguyen, Sushant Khanal, Jinyu Zhang, Xiao Y. Wu, Mohamed El Gazzar, Shunbin Ning, Jonathan P. Moorman, Zhi Q. Yao
Summary: Oxidative stress leads to dual injury in T cells through crosstalk between telomeres and mitochondria, resulting in cell death. Blocking ROS production can reverse this damage.
Article
Obstetrics & Gynecology
Songthip T. Ounpraseuth, Everett F. Magann, Horace J. Spencer, Nader Z. Rabie, Adam T. Sandlin
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2017)
Article
Surgery
Todd Maxson, Charles D. Mabry, Michael J. Sutherland, Ronald D. Robertson, James O. Booker, Terry Collins, Horace J. Spencer, Charles F. Rinker, Teri L. Sanddal, Nels D. Sanddal
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2017)
Article
Surgery
Christian D. Simmons, Ahsan T. Ali, Kousta Foteh, Matthew R. Abate, Matthew R. Smeds, Horace J. Spencer, G. Patrick Clagett
JOURNAL OF VASCULAR SURGERY
(2017)
Article
Rheumatology
Nasim Ahmed Khan, Horace Jack Spencer, Elena Nikiphorou, Antonio Naranjo, Rieki Alten, Rodica M. Chirieac, Alexandros A. Drosos, Pal Geher, Nevsun Inanc, Eduardo Kerzberg, Codrina Mihaela Ancuta, Ruediger Muller, Lykke Ornbjerg, Tuulliki Sokka
Article
Surgery
Michael C. Scott, Horace J. Spencer, Ahsan T. Ali, Mohammed M. Moursi, Guillermo A. Escobar, Lewis C. Lyons, Matthew R. Smeds
ANNALS OF VASCULAR SURGERY
(2018)
Article
Nutrition & Dietetics
Il-Young Kim, Scott Schutzler, Amy M. Schrader, Horace J. Spencer, Gohar Azhar, Robert R. Wolfe, Arny A. Ferrando
CLINICAL NUTRITION
(2018)
Article
Immunology
Sandra G. Morrison, Amanda M. Giebel, Evelyn C. Toh, Horace J. Spencer, David E. Nelson, Richard P. Morrison
INFECTION AND IMMUNITY
(2018)
Article
Rheumatology
Nasim Ahmed Khan, Chau L. Nguyen, Talha Khawar, Horace Spencer, Karina D. Torralba
Article
Ophthalmology
Paul H. Phillips, Katherine J. Fray, A. Paula Grigorian, Hanya Qureshi, Horace J. Spencer, Brita S. Rook
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Chemistry, Medicinal
Aura M. Ramirez, Stephanie D. Byrum, Karen E. Beenken, Charity Washam, Rick D. Edmondson, Samuel G. Mackintosh, Horace J. Spencer, Alan J. Tackett, Mark S. Smeltzer
ACS INFECTIOUS DISEASES
(2020)
Article
Pediatrics
Lindsay Arthur, Kenneth Knecht, Jennifer Ferry, Debby Grigsby, Horace Spencer, Dala Zakaria
Summary: This study found that right ventricular dysfunction and changes in left ventricular thickness are associated with acute cellular rejection (ACR) following heart transplantation in children. However, these echocardiographic markers improve after the episode of rejection. Additionally, these markers were not found to have prognostic significance for graft integrity in children with heart transplantation.
PEDIATRIC TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Kristin Larsen, Horace Spencer, Meera Mohan, Clyde Bailey, Kerri Hill, Mathew Kottarathara, Richa Parikh, Shadiqul Hoque, Amani Erra, Angel A. Mitma, Pankaj Mathur, Lakshmi Yarlagadda, Sravani Gundarlapalli, Yetunde Ogunsesan, Munawwar Hussain, Nishanth Thalambedu, Jaskirat Sehti, Samer Al Hadidi, Sharmilan Thanendrarajan, Monica Graziutti, Maurizio Zangari, Bart Barlogie, Frits van Rhee, Guido Tricot, Carolina Schinke
Summary: High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is the standard treatment for multiple myeloma (MM) patients. This study aimed to compare outpatient and inpatient ASCT and identify factors associated with hospitalization during outpatient ASCT.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Al-Ola Abdallah, Hannah Coleman, Mohamed Kamel, Rodney Davis, Teri Landrum, Horace Spencer, Sam Mackintosh, Fade A. Mahmoud, Natasa Milojkovic, Chester Wicker, Konstantinos Arnaoutakis, Mayumi Nakagawa
SAGE OPEN MEDICINE
(2018)
Article
Ophthalmology
John D. Pemberton, Michael Salter, Aaron Fay, Bradley Thuro, Horace Spencer, Omar Dajani
ORBIT-AN INTERNATIONAL JOURNAL ON ORBITAL DISORDERS AND FACIAL RECONSTRUCTIVE SURGERY
(2018)
Review
Obstetrics & Gynecology
Everett F. Magann, Kjell Haram, Songthip Ounpraseuth, Jan H. Mortensen, Horace J. Spencer, John C. Morrison
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2017)