Mechanisms of Mitochondrial DNA Repair in Mammals

Mitochondrial poly(ADP-ribose) polymerase: The Wizard of Oz at work

(2016) Attila Brunyanszki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions

(2016) Satish Kumar Tadi et al.   MOLECULAR BIOLOGY OF THE CELL

Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA

(2016) Morten Scheibye-Knudsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?

(2015) Agnel Sfeir et al.   TRENDS IN BIOCHEMICAL SCIENCES

Slow mitochondrial repair of 5′-AMP renders mtDNA susceptible to damage in APTX deficient cells

(2015) Mansour Akbari et al.   Scientific Reports

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

(2014) Evandro Fei Fang et al.   CELL

A High-Fat Diet and NAD + Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome

(2014) Morten Scheibye-Knudsen et al.   Cell Metabolism

Base excision repair: A critical player in many games

(2014) Susan S. Wallace   DNA REPAIR

Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2)

(2014) Yves Pommier et al.   DNA REPAIR

Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function

(2014) Bartosz Szczesny et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage

(2014) James E. Cleaver et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of TDP1 and APTX in mitochondrial DNA repair

(2013) Martin Meagher et al.   BIOCHIMIE

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Mechanism of Homologous Recombination and Implications for Aging-Related Deletions in Mitochondrial DNA

(2013) X. J. Chen   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Human Rad51 promotes mitochondrial DNA synthesis under conditions of increased replication stress

(2013) Jay M. Sage et al.   MITOCHONDRION

Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease

(2013) Cornelia Kornblum et al.   NATURE GENETICS

Increased Oxidative Metabolism in the Li–Fraumeni Syndrome

(2013) Ping-Yuan Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations That Are Inconsistent with Oxidative Damage

(2013) Scott R. Kennedy et al.   PLoS Genetics

An altered redox balance mediates the hypersensitivity of Cockayne syndrome primary fibroblasts to oxidative stress

(2012) Barbara Pascucci et al.   AGING CELL

Somatic mitochondrial DNA mutations in early parkinson and incidental lewy body disease

(2012) Michael T. Lin et al.   ANNALS OF NEUROLOGY

Evidence of animal mtDNA recombination between divergent populations of the potato cyst nematode Globodera pallida

(2012) Angelique H. Hoolahan et al.   GENETICA

Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy

(2012) Morten Scheibye-Knudsen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Minimizing the damage: repair pathways keep mitochondrial DNA intact

(2012) Lawrence Kazak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human Cockayne syndrome B protein reciprocally communicates with mitochondrial proteins and promotes transcriptional elongation

(2012) Brian R. Berquist et al.   NUCLEIC ACIDS RESEARCH

Mre11 is expressed in mammalian mitochondria where it binds to mitochondrial DNA

(2011) Natalia I. Dmitrieva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The generation of mitochondrial DNA large-scale deletions in human cells

(2011) Tao Chen et al.   JOURNAL OF HUMAN GENETICS

Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair

(2011) Nasser Tahbaz et al.   NUCLEIC ACIDS RESEARCH

Aprataxin localizes to mitochondria and preserves mitochondrial function

(2011) P. Sykora et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mitochondrial transcription factor A functions in mitochondrial base excision repair

(2010) Chandrika Canugovi et al.   DNA REPAIR

Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane

(2010) Maria D. Aamann et al.   FASEB JOURNAL

Human aging and somatic point mutations in mtDNA: a comparative study of generational differences (grandparents and grandchildren)

(2010) Anderson Nonato do Rosário Marinho et al.   GENETICS AND MOLECULAR BIOLOGY

Heteroplasmic mitochondrial DNA mutations in normal and tumour cells

(2010) Yiping He et al.   NATURE

Regulation of base excision repair: Ntg1 nuclear and mitochondrial dynamic localization in response to genotoxic stress

(2010) Dan B. Swartzlander et al.   NUCLEIC ACIDS RESEARCH

Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria

(2010) B. B. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Random Point Mutations with Major Effects on Protein-Coding Genes Are the Driving Force behind Premature Aging in mtDNA Mutator Mice

(2009) Daniel Edgar et al.   Cell Metabolism

p53 Improves Aerobic Exercise Capacity and Augments Skeletal Muscle Mitochondrial DNA Content

(2009) Joon-Young Park et al.   CIRCULATION RESEARCH

Novel DNA mismatch-repair activity involving YB-1 in human mitochondria

(2009) Nadja C. de Souza-Pinto et al.   DNA REPAIR

Parthanatos, a messenger of death

(2009) Karen Kate David   Frontiers in Bioscience-Landmark

Mitochondrial Localization of PARP-1 Requires Interaction with Mitofilin and Is Involved in the Maintenance of Mitochondrial DNA Integrity

(2009) Marianna N. Rossi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Heart Mitochondrial DNA Is Organized in Complex Catenated Networks Containing Abundant Four-way Junctions and Replication Forks

(2009) Jaakko L. O. Pohjoismäki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks

(2009) S. R. Bacman et al.   NUCLEIC ACIDS RESEARCH

Phenotype analysis of Saccharomyces cerevisiae mutants with deletions in Pir cell wall glycoproteins

(2008) Marián Mazáň et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

p53 in mitochondria enhances the accuracy of DNA synthesis

(2008) M Bakhanashvili et al.   CELL DEATH AND DIFFERENTIATION

The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging

(2008) Tinna Stevnsner et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Single-strand break repair and genetic disease

(2008) Keith W. Caldecott   NATURE REVIEWS GENETICS

Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53

(2008) T. S. Wong et al.   NUCLEIC ACIDS RESEARCH

Leigh and Leigh-Like Syndrome in Children and Adults

(2008) Josef Finsterer   PEDIATRIC NEUROLOGY