Role of Exosomes in the Regulation of T-cell Mediated Immune Responses and in Autoimmune Disease

Extracellular vesicles: A new therapeutic strategy for joint conditions

(2018) Miguel Tofiño-Vian et al.   BIOCHEMICAL PHARMACOLOGY

Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

(2018) Daniel Torralba et al.   Nature Communications

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Putting the Immunologic Brakes on Cancer

(2018) Jedd Wolchok   CELL

Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic β Cell Death and May Contribute to Type 1 Diabetes Development

(2018) Claudiane Guay et al.   Cell Metabolism

Mesenchymal stromal cells and autoimmunity

(2017) Vito Pistoia et al.   INTERNATIONAL IMMUNOLOGY

The role of exosomes in CNS inflammation and their involvement in multiple sclerosis

(2017) Igor Selmaj et al.   JOURNAL OF NEUROIMMUNOLOGY

On How Fas Apoptosis-Independent Pathways Drive T Cell Hyperproliferation and Lymphadenopathy in lpr Mice

(2017) Dimitrios Balomenos et al.   Frontiers in Immunology

Extracellular vesicles derived from T regulatory cells suppress T cell proliferation and prolong allograft survival

(2017) Sistiana Aiello et al.   Scientific Reports

Exosomes in immunoregulation of chronic lung diseases

(2016) K. P. Hough et al.   ALLERGY

Recent advances of exosomes in immune modulation and autoimmune diseases

(2016) Lina Tan et al.   AUTOIMMUNITY

High-order TRAIL oligomer formation in TRAIL-coated lipid nanoparticles enhances DR5 cross-linking and increases antitumour effect against colon cancer

(2016) Diego De Miguel et al.   CANCER LETTERS

Onto better TRAILs for cancer treatment

(2016) D de Miguel et al.   CELL DEATH AND DIFFERENTIATION

Articular cartilage vesicles and calcium crystal deposition diseases

(2016) Ann K. Rosenthal   CURRENT OPINION IN RHEUMATOLOGY

Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity

(2016) Chiara Cianciaruso et al.   DIABETES

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation

(2016) Ana C. Anderson et al.   IMMUNITY

Functions of Exosomes and Microbial Extracellular Vesicles in Allergy and Contact and Delayed-Type Hypersensitivity

(2016) Katarzyna Nazimek et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Regulation of chronic inflammatory and immune processes by extracellular vesicles

(2016) Paul D. Robbins et al.   JOURNAL OF CLINICAL INVESTIGATION

Exosome in intestinal mucosal immunity

(2016) An Tao Xu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway

(2016) Vassiliki A. Boussiotis   NEW ENGLAND JOURNAL OF MEDICINE

Proteomic profiling of dextran sulfate sodium induced acute ulcerative colitis mice serum exosomes and their immunomodulatory impact on macrophages

(2016) Wing-Yan Wong et al.   PROTEOMICS

Comparative proteomics of exosomes secreted by tumoral Jurkat T cells and normal human T cell blasts unravels a potential tumorigenic role for valosin-containing protein

(2016) Alberto Bosque et al.   Oncotarget

Exosomes Mediate LTB4 Release during Neutrophil Chemotaxis

(2016) Ritankar Majumdar et al.   PLOS BIOLOGY

Endothelial cells suppress monocyte activation through secretion of extracellular vesicles containing antiinflammatory microRNAs

(2015) M.-S. Njock et al.   BLOOD

Protein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes

(2015) C Mazzeo et al.   CELL DEATH AND DIFFERENTIATION

Macrophages play an essential role in antigen-specific immune suppression mediated by T CD8+cell-derived exosomes

(2015) Katarzyna Nazimek et al.   IMMUNOLOGY

Liposome-bound TRAIL induces superior DR5 clustering and enhanced DISC recruitment in histiocytic lymphoma U937 cells

(2015) Diego De Miguel et al.   LEUKEMIA RESEARCH

Oral administration of bovine milk derived extracellular vesicles attenuates arthritis in two mouse models

(2015) Onno J. Arntz et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

(2015) Sonia A. Melo et al.   NATURE

Decreased activation-induced cell death by EBV-transformed B-cells from a patient with autoimmune lymphoproliferative syndrome caused by a novel FASLG mutation

(2015) Raquel Ruiz-García et al.   PEDIATRIC RESEARCH

Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells

(2015) Anthony N. Vomund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis

(2015) Sarah E. Headland et al.   Science Translational Medicine

Distinct p21 requirements for regulating normal and self-reactive T cells through IFN-γ production

(2015) Lidia Daszkiewicz et al.   Scientific Reports

MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells

(2014) Isobel S. Okoye et al.   IMMUNITY

Endothelial Microparticles Interact with and Support the Proliferation of T Cells

(2014) Julie Wheway et al.   JOURNAL OF IMMUNOLOGY

Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations

(2014) Desirée Schubert et al.   NATURE MEDICINE

Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity

(2013) Krzysztof Bryniarski et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Intracellular Interactome of Tetraspanin-enriched Microdomains Reveals Their Function as Sorting Machineries toward Exosomes

(2013) Daniel Perez-Hernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

(2013) Fatih Arslan et al.   Stem Cell Research

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

(2013) Carsten Frühbeis et al.   PLOS BIOLOGY

Bronchoalveolar lavage fluid exosomes contribute to cytokine and leukotriene production in allergic asthma

(2012) P. Torregrosa Paredes et al.   ALLERGY

Myeloid microvesicles are a marker and therapeutic target for neuroinflammation

(2012) Claudia Verderio et al.   ANNALS OF NEUROLOGY

The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes

(2012) Nathalie Cloutier et al.   EMBO Molecular Medicine

Transfer of extracellular vesicles during immune cell-cell interactions

(2012) Cristina Gutiérrez-Vázquez et al.   IMMUNOLOGICAL REVIEWS

Immune Surveillance Properties of Human NK Cell-Derived Exosomes

(2012) L. Lugini et al.   JOURNAL OF IMMUNOLOGY

Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity

(2012) Alessandra Lo Cicero et al.   MATRIX BIOLOGY

Characterization of Membrane-shed Microvesicles from Cytokine-stimulated β-Cells Using Proteomics Strategies

(2012) Giuseppe Palmisano et al.   MOLECULAR & CELLULAR PROTEOMICS

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Intercellular communication: diverse structures for exchange of genetic information

(2012) Maria Mittelbrunn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms and clinical relevance of TRAIL-triggered responses in the synovial fibroblasts of patients with rheumatoid arthritis

(2011) Rachel Audo et al.   ARTHRITIS AND RHEUMATISM

Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes

(2011) R Alonso et al.   CELL DEATH AND DIFFERENTIATION

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Liposome-bound APO2L/TRAIL is an effective treatment in a rabbit model of rheumatoid arthritis

(2010) Luis Martinez-Lostao et al.   ARTHRITIS AND RHEUMATISM

Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome protein

(2010) N. P. Nikolov et al.   BLOOD

Dendritic Cells Recruit T Cell Exosomes via Exosomal LFA-1 Leading to Inhibition of CD8+ CTL Responses through Downregulation of Peptide/MHC Class I and Fas Ligand-Mediated Cytotoxicity

(2010) Y. Xie et al.   JOURNAL OF IMMUNOLOGY

Induction of pregnancy during established EAE halts progression of CNS autoimmune injury via pregnancy-specific serum factors☆

(2010) NaTosha N. Gatson et al.   JOURNAL OF NEUROIMMUNOLOGY

The pleiotropic effect of TRAIL on tumor-like synovial fibroblasts from rheumatoid arthritis patients is mediated by caspases

(2009) R Audo et al.   CELL DEATH AND DIFFERENTIATION

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

(2009) Lorraine A. O’ Reilly et al.   NATURE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Rapid regression of lymphadenopathy upon rapamycin treatment in a child with autoimmune lymphoproliferative syndrome

(2009) Janić Mihailo Dragana et al.   PEDIATRIC BLOOD & CANCER

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Cell cycle regulation by FasL and Apo2L/TRAIL in human T-cell blasts. Implications for autoimmune lymphoproliferative syndromes

(2008) Alberto Bosque et al.   JOURNAL OF LEUKOCYTE BIOLOGY